The results presented here suggest that miR-629-5p functions as a tumor promoter by improving proliferation and migration and repressing apoptosis and 5-FU sensitivity in colorectal cancer progression by directly down-regulating CXXC4.
CXXC4 is a novel potential tumor suppressor directly regulated by EZH2 and its expression is a significant prognosis factor for patients with early stages of gastric cancer.
IDAX expression results in caspase activation and TET2 protein downregulation in a manner that depends on DNA binding through the IDAX CXXC domain suggesting that IDAX recruits TET2 to DNA before degradation
Decreased CXXC4 was associated with kidney cancer metastasis poor survival beta-catenin translocation cell proliferation reduced apoptosis in response to cancer drugs and upregulation of genes involed in proliferation invasion and cell survival.
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