Q9H255 · O51E2_HUMAN
- ProteinOlfactory receptor 51E2
- GeneOR51E2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids320 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Olfactory receptor (PubMed:27226631, PubMed:29249973).
Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:19389702, PubMed:27226631, PubMed:29249973).
The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca2+, cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973).
Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631).
Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973).
Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498).
May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702).
Activated by L-lactate in glomus cells (By similarity).
Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:19389702, PubMed:27226631, PubMed:29249973).
The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca2+, cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973).
Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631).
Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973).
Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498).
May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702).
Activated by L-lactate in glomus cells (By similarity).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | intracellular organelle | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | nuclear steroid receptor activity | |
Molecular Function | olfactory receptor activity | |
Molecular Function | signaling receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cell migration | |
Biological Process | cellular response to fatty acid | |
Biological Process | melanocyte differentiation | |
Biological Process | melanocyte proliferation | |
Biological Process | positive regulation of blood pressure | |
Biological Process | positive regulation of renin secretion into blood stream | |
Biological Process | steroid hormone receptor signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 51E2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H255
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Early endosome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-24 | Extracellular | ||||
Sequence: MSSCNFTHATFVLIGIPGLEKAHF | ||||||
Transmembrane | 25-45 | Helical; Name=1 | ||||
Sequence: WVGFPLLSMYVVAMFGNCIVV | ||||||
Topological domain | 46-53 | Cytoplasmic | ||||
Sequence: FIVRTERS | ||||||
Transmembrane | 54-74 | Helical; Name=2 | ||||
Sequence: LHAPMYLFLCMLAAIDLALST | ||||||
Topological domain | 75-98 | Extracellular | ||||
Sequence: STMPKILALFWFDSREISFEACLT | ||||||
Transmembrane | 99-119 | Helical; Name=3 | ||||
Sequence: QMFFIHALSAIESTILLAMAF | ||||||
Topological domain | 120-138 | Cytoplasmic | ||||
Sequence: DRYVAICHPLRHAAVLNNT | ||||||
Transmembrane | 139-159 | Helical; Name=4 | ||||
Sequence: VTAQIGIVAVVRGSLFFFPLP | ||||||
Topological domain | 160-195 | Extracellular | ||||
Sequence: LLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNV | ||||||
Transmembrane | 196-216 | Helical; Name=5 | ||||
Sequence: VYGLTAILLVMGVDVMFISLS | ||||||
Topological domain | 217-236 | Cytoplasmic | ||||
Sequence: YFLIIRTVLQLPSKSERAKA | ||||||
Transmembrane | 237-257 | Helical; Name=6 | ||||
Sequence: FGTCVSHIGVVLAFYVPLIGL | ||||||
Topological domain | 258-272 | Extracellular | ||||
Sequence: SVVHRFGNSLHPIVR | ||||||
Transmembrane | 273-293 | Helical; Name=7 | ||||
Sequence: VVMGDIYLLLPPVINPIIYGA | ||||||
Topological domain | 294-320 | Cytoplasmic | ||||
Sequence: KTKQIRTRVLAMFKISCDKDLQAVGGK |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 539 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000150751 | 1-320 | Olfactory receptor 51E2 | |||
Sequence: MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 96↔178 | |||||
Sequence: CLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in the prostate (PubMed:11707321).
Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:11707321, PubMed:16491480, PubMed:29249973).
In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973).
Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).
Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:11707321, PubMed:16491480, PubMed:29249973).
In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973).
Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).
Induction
Up-regulated in prostate cancer.
Gene expression databases
Organism-specific databases
Structure
Sequence
- Sequence statusComplete
- Length320
- Mass (Da)35,493
- Last updated2001-03-01 v1
- Checksum03582CC2AAB6E2C6
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9PPJ8 | E9PPJ8_HUMAN | OR51E2 | 83 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF311306 EMBL· GenBank· DDBJ | AAG40776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF369708 EMBL· GenBank· DDBJ | AAK38728.1 EMBL· GenBank· DDBJ | mRNA | ||
AY033942 EMBL· GenBank· DDBJ | AAK57550.1 EMBL· GenBank· DDBJ | mRNA | ||
AK314051 EMBL· GenBank· DDBJ | BAG36760.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68829.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC020768 EMBL· GenBank· DDBJ | AAH20768.1 EMBL· GenBank· DDBJ | mRNA | ||
BK004368 EMBL· GenBank· DDBJ | DAA04766.1 EMBL· GenBank· DDBJ | Genomic DNA |