Q9H255 · O51E2_HUMAN

  • Protein
    Olfactory receptor 51E2
  • Gene
    OR51E2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Olfactory receptor (PubMed:27226631, PubMed:29249973).
Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:19389702, PubMed:27226631, PubMed:29249973).
The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca2+, cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973).
Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631).
Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973).
Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498).
May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702).
Activated by L-lactate in glomus cells (By similarity).

Caution

Contradictory results have been reported for activation of this receptor by beta-ionone in human and mouse. Beta-ionone does not activate OR51E2 in mouse. This difference may depend on the different methods used for the experiment or may be due to species difference.

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Cellular Componentintracellular organelle
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Molecular Functionnuclear steroid receptor activity
Molecular Functionolfactory receptor activity
Molecular Functionsignaling receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processcell migration
Biological Processcellular response to fatty acid
Biological Processmelanocyte differentiation
Biological Processmelanocyte proliferation
Biological Processpositive regulation of blood pressure
Biological Processpositive regulation of renin secretion into blood stream
Biological Processsteroid hormone receptor signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Olfactory receptor 51E2
  • Alternative names
    • HPRAJ
    • Olfactory receptor OR11-16
    • Prostate-specific G-protein coupled receptor

Gene names

    • Name
      OR51E2
    • Synonyms
      PSGR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H255
  • Secondary accessions
    • B2RA63
    • Q6IF94

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-24Extracellular
Transmembrane25-45Helical; Name=1
Topological domain46-53Cytoplasmic
Transmembrane54-74Helical; Name=2
Topological domain75-98Extracellular
Transmembrane99-119Helical; Name=3
Topological domain120-138Cytoplasmic
Transmembrane139-159Helical; Name=4
Topological domain160-195Extracellular
Transmembrane196-216Helical; Name=5
Topological domain217-236Cytoplasmic
Transmembrane237-257Helical; Name=6
Topological domain258-272Extracellular
Transmembrane273-293Helical; Name=7
Topological domain294-320Cytoplasmic

Keywords

Disease & Variants

Variants

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The viewer provides 539 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001507511-320Olfactory receptor 51E2
Glycosylation5N-linked (GlcNAc...) asparagine
Disulfide bond96↔178

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in the prostate (PubMed:11707321).
Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:11707321, PubMed:16491480, PubMed:29249973).
In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973).
Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).

Induction

Up-regulated in prostate cancer.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    320
  • Mass (Da)
    35,493
  • Last updated
    2001-03-01 v1
  • Checksum
    03582CC2AAB6E2C6
MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E9PPJ8E9PPJ8_HUMANOR51E283

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF311306
EMBL· GenBank· DDBJ
AAG40776.1
EMBL· GenBank· DDBJ
Genomic DNA
AF369708
EMBL· GenBank· DDBJ
AAK38728.1
EMBL· GenBank· DDBJ
mRNA
AY033942
EMBL· GenBank· DDBJ
AAK57550.1
EMBL· GenBank· DDBJ
mRNA
AK314051
EMBL· GenBank· DDBJ
BAG36760.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW68829.1
EMBL· GenBank· DDBJ
Genomic DNA
BC020768
EMBL· GenBank· DDBJ
AAH20768.1
EMBL· GenBank· DDBJ
mRNA
BK004368
EMBL· GenBank· DDBJ
DAA04766.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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