Q9H1R2 · DUS15_HUMAN
- ProteinDual specificity protein phosphatase 15
- GeneDUSP15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids295 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).
Isoform 3
May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity).
Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 85 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine/serine/threonine phosphatase activity | |
Biological Process | dephosphorylation | |
Biological Process | regulation of oligodendrocyte differentiation | |
Biological Process | signal transduction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity protein phosphatase 15
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H1R2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 85 | Loss of phosphatase activity. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 384 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | In isoform Q9H1R2-3; Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000094824 | 1-295 | Dual specificity protein phosphatase 15 | |||
Sequence: MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR | ||||||
Lipidation | 2 | In isoform Q9H1R2-3; N-myristoyl glycine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9H1R2 | NCK1 P16333 | 2 | EBI-1752795, EBI-389883 | |
BINARY | Q9H1R2 | PLCG1 P19174 | 2 | EBI-1752795, EBI-79387 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-141 | Tyrosine-protein phosphatase | ||||
Sequence: MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQ | ||||||
Region | 251-272 | Disordered | ||||
Sequence: SSSCTLSASTERPDGSSTPGNP |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q9H1R2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length295
- Mass (Da)31,882
- Last updated2003-04-30 v4
- Checksum28F8A687ECB5C219
Q9H1R2-2
- Name2
Q9H1R2-3
- Name3
- SynonymsA
Q9H1R2-4
- Name4
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_019228 | 1-4 | in isoform 3 | |||
Sequence: MTEG → MGNGMTK | ||||||
Alternative sequence | VSP_043107 | 1-100 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007292 | 143-232 | in isoform 2, isoform 3 and isoform 4 | |||
Sequence: GARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQ → LRRQLEERFGESPFRDEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTVQRLVPRTPREAHRPLPLLARVKQTFSCLPRCLSRKGGK | ||||||
Alternative sequence | VSP_007293 | 233-295 | in isoform 2, isoform 3 and isoform 4 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK091960 EMBL· GenBank· DDBJ | BAG52450.1 EMBL· GenBank· DDBJ | mRNA | ||
AK097430 EMBL· GenBank· DDBJ | BAC05048.1 EMBL· GenBank· DDBJ | mRNA | ||
AL160175 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471077 EMBL· GenBank· DDBJ | EAW76410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC056911 EMBL· GenBank· DDBJ | AAH56911.1 EMBL· GenBank· DDBJ | mRNA | ||
BM554314 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |