Q9H1M4 · DB127_HUMAN
- ProteinBeta-defensin 127
- GeneDEFB127
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has antibacterial activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to Gram-negative bacterium | |
Biological Process | innate immune response |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-defensin 127
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H1M4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_048864 | 31 | in dbSNP:rs12624954 | |||
Sequence: G → R | ||||||
Natural variant | VAR_048865 | 71 | in dbSNP:rs16995685 | |||
Sequence: R → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 122 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, peptide, disulfide bond, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MGLFMIIAILLFQKPTVTEQ | ||||||
Peptide | PRO_0000007002 | 21-63 | Beta-defensin 127 | |||
Sequence: LKKCWNNYVQGHCRKICRVNEVPEALCENGRYCCLNIKELEAC | ||||||
Disulfide bond | 24↔53 | |||||
Sequence: CWNNYVQGHCRKICRVNEVPEALCENGRYC | ||||||
Disulfide bond | 33↔47 | |||||
Sequence: CRKICRVNEVPEALC | ||||||
Disulfide bond | 37↔54 | |||||
Sequence: CRVNEVPEALCENGRYCC | ||||||
Propeptide | PRO_0000007003 | 66-99 | ||||
Sequence: ITKPPRPKPATLALTLQDYVTIIENFPSLKTQST |
Keywords
- PTM
Proteomic databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9H1M4 | AQP6 Q13520 | 3 | EBI-10305240, EBI-13059134 | |
BINARY | Q9H1M4 | ASZ1 Q8WWH4 | 3 | EBI-10305240, EBI-12239061 | |
BINARY | Q9H1M4 | AURKAIP1 Q9NWT8 | 3 | EBI-10305240, EBI-448665 | |
BINARY | Q9H1M4 | BCL2L13 Q9BXK5 | 3 | EBI-10305240, EBI-747430 | |
BINARY | Q9H1M4 | CD79A P11912 | 3 | EBI-10305240, EBI-7797864 | |
BINARY | Q9H1M4 | CPLX4 Q7Z7G2 | 3 | EBI-10305240, EBI-18013275 | |
BINARY | Q9H1M4 | EBP Q15125 | 3 | EBI-10305240, EBI-3915253 | |
BINARY | Q9H1M4 | FAM174A Q8TBP5 | 3 | EBI-10305240, EBI-18636064 | |
BINARY | Q9H1M4 | MFSD14B Q5SR56 | 3 | EBI-10305240, EBI-373355 | |
BINARY | Q9H1M4 | MMGT1 Q8N4V1 | 3 | EBI-10305240, EBI-6163737 | |
BINARY | Q9H1M4 | PIANP Q8IYJ0 | 3 | EBI-10305240, EBI-12204277 | |
BINARY | Q9H1M4 | TFEC O14948 | 3 | EBI-10305240, EBI-3916574 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length99
- Mass (Da)11,343
- Last updated2001-03-01 v1
- ChecksumC9CBDB27D17AF380
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 74-77 | in Ref. 5; AAM93920 | ||||
Sequence: PATL → QHLH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF525929 EMBL· GenBank· DDBJ | AAP47222.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358796 EMBL· GenBank· DDBJ | AAQ89156.1 EMBL· GenBank· DDBJ | mRNA | ||
AL360078 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC069486 EMBL· GenBank· DDBJ | AAH69486.1 EMBL· GenBank· DDBJ | mRNA | ||
BC109395 EMBL· GenBank· DDBJ | AAI09396.1 EMBL· GenBank· DDBJ | mRNA | ||
AY122479 EMBL· GenBank· DDBJ | AAM93920.1 EMBL· GenBank· DDBJ | mRNA |