Q9H0I2 · ENKD1_HUMAN
- ProteinEnkurin domain-containing protein 1
- GeneENKD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35072334, PubMed:35197565).
Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565).
This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity).
Required for the assembly of both primary and motile cilia (PubMed:35301795).
Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795).
Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565).
This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity).
Required for the assembly of both primary and motile cilia (PubMed:35301795).
Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | 9+0 non-motile cilium | |
Cellular Component | centriole | |
Cellular Component | centrosome | |
Cellular Component | ciliary basal body | |
Cellular Component | ciliary base | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | microtubule cytoskeleton | |
Cellular Component | spindle pole | |
Molecular Function | alpha-tubulin binding | |
Molecular Function | microtubule binding | |
Biological Process | establishment of mitotic spindle orientation | |
Biological Process | motile cilium assembly | |
Biological Process | non-motile cilium assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnkurin domain-containing protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H0I2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (PubMed:35301795).
In ciliated cells, detected at the basal body of the cilium (PubMed:35301795).
Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (PubMed:35072334).
In ciliated cells, detected at the basal body of the cilium (PubMed:35301795).
Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (PubMed:35072334).
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 436 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000265931 | 1-346 | Enkurin domain-containing protein 1 | |||
Sequence: MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD | ||||||
Modified residue | 91 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 136 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
During the cell cycle, highly expressed in S, G2 and M phases.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with alpha-tubulin (PubMed:35197565).
Interacts (via central region) with CCP110 (via N-terminal region); competes with CEP97 for binding to CCP110 (By similarity).
Interacts (via central region) with CCP110 (via N-terminal region); competes with CEP97 for binding to CCP110 (By similarity).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-35 | Disordered | ||||
Sequence: MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEG | ||||||
Region | 91-171 | Required for binding to microtubules | ||||
Sequence: SLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRC | ||||||
Region | 114-137 | Disordered | ||||
Sequence: RFREQERSREQGQPRPLKALWRSP | ||||||
Region | 167-197 | Disordered | ||||
Sequence: AHSRCGPGLPPPHVSSPQPTPPGPEAKEPGL | ||||||
Compositional bias | 176-192 | Pro residues | ||||
Sequence: PPPHVSSPQPTPPGPEA | ||||||
Domain | 251-343 | Enkurin | ||||
Sequence: ERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVK | ||||||
Region | 260-280 | Disordered | ||||
Sequence: AEARKQSQPDPAMPPGHTRMP |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9H0I2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length346
- Mass (Da)38,759
- Last updated2001-03-01 v1
- ChecksumEDB07D64A0BB23FF
Q9H0I2-2
- Name2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
R4GN60 | R4GN60_HUMAN | ENKD1 | 225 | ||
A0A087X0D0 | A0A087X0D0_HUMAN | ENKD1 | 89 |
Features
Showing features for alternative sequence, compositional bias.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL136786 EMBL· GenBank· DDBJ | CAB66720.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358834 EMBL· GenBank· DDBJ | AAQ89193.1 EMBL· GenBank· DDBJ | mRNA | ||
BC008284 EMBL· GenBank· DDBJ | AAH08284.1 EMBL· GenBank· DDBJ | mRNA |