Q9H0C1 · ZMY12_HUMAN

  • Protein
    Zinc finger MYND domain-containing protein 12
  • Gene
    ZMYND12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for sperm flagellum function and male fertility.

Features

Showing features for binding site.

136550100150200250300350
TypeIDPosition(s)Description
Binding site17Zn2+ 1 (UniProtKB | ChEBI)
Binding site20Zn2+ 1 (UniProtKB | ChEBI)
Binding site28Zn2+ 2 (UniProtKB | ChEBI)
Binding site31Zn2+ 2 (UniProtKB | ChEBI)
Binding site37Zn2+ 1 (UniProtKB | ChEBI)
Binding site41Zn2+ 1 (UniProtKB | ChEBI)
Binding site50Zn2+ 2 (UniProtKB | ChEBI)
Binding site54Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentsperm flagellum
Molecular Functionmetal ion binding
Biological Processflagellated sperm motility
Biological Processsperm axoneme assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger MYND domain-containing protein 12

Gene names

    • Name
      ZMYND12

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H0C1
  • Secondary accessions
    • Q5VUS6
    • Q8TC87
    • Q96M51

Proteomes

Organism-specific databases

Subcellular Location

Note: Found along the full length of the sperm flagellum.

Keywords

Disease & Variants

Involvement in disease

  • Loss-of-function variants in ZMYND12 may play a role in male infertility characterized by severe asthenozoospermia with over 5% of the spermatozoa displaying flagellar abnormalities such as short, absent, coiled, bent, or irregular flagella

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_088858145-365found in patients with asthenoteratozoospermia; likely pathogenic; severe axonemal disorganization in sperm cells; CFAP70, DNAH1, DNALI1, SPAG6, TTC29 and WDR66 proteins not detected in sperm cells
Natural variantVAR_018425316in dbSNP:rs1034268

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 403 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002183161-365Zinc finger MYND domain-containing protein 12

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed predominantly in the testis.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9H0C1ABI2 Q9NYB9-25EBI-12030590, EBI-11096309
BINARY Q9H0C1AIRIM Q9NX043EBI-12030590, EBI-8643161
BINARY Q9H0C1ARHGAP8 P85298-43EBI-12030590, EBI-9523517
BINARY Q9H0C1ARMC8 Q8IUR7-63EBI-12030590, EBI-11942961
BINARY Q9H0C1ATOSB Q7L5A33EBI-12030590, EBI-745689
BINARY Q9H0C1BMAL1 O00327-85EBI-12030590, EBI-11991546
BINARY Q9H0C1CCDC116 Q8IYX33EBI-12030590, EBI-744311
BINARY Q9H0C1CCDC24 Q8N4L83EBI-12030590, EBI-1104933
BINARY Q9H0C1CHCHD2 Q9Y6H13EBI-12030590, EBI-2321769
BINARY Q9H0C1CWF19L2 Q2TBE03EBI-12030590, EBI-5453285
BINARY Q9H0C1DMRT3 Q9NQL93EBI-12030590, EBI-9679045
BINARY Q9H0C1EVX2 Q038283EBI-12030590, EBI-17280301
BINARY Q9H0C1FAM222B Q8WU583EBI-12030590, EBI-2807642
BINARY Q9H0C1FAM50B Q9Y2473EBI-12030590, EBI-742802
BINARY Q9H0C1FAM90A1 Q86YD73EBI-12030590, EBI-6658203
BINARY Q9H0C1GPKOW Q929173EBI-12030590, EBI-746309
BINARY Q9H0C1GSTZ1 O437083EBI-12030590, EBI-748043
BINARY Q9H0C1HAPLN2 Q9GZV73EBI-12030590, EBI-11956675
BINARY Q9H0C1HDAC4 P56524-23EBI-12030590, EBI-11953488
BINARY Q9H0C1HOXB5 P090673EBI-12030590, EBI-3893317
BINARY Q9H0C1HOXC9 P312743EBI-12030590, EBI-1779423
BINARY Q9H0C1HR O435933EBI-12030590, EBI-2880706
BINARY Q9H0C1HSF4 Q9ULV5-23EBI-12030590, EBI-12056251
BINARY Q9H0C1ILF2 Q129053EBI-12030590, EBI-357925
BINARY Q9H0C1INCA1 Q0VD863EBI-12030590, EBI-6509505
BINARY Q9H0C1KANK2 Q63ZY33EBI-12030590, EBI-2556193
BINARY Q9H0C1LENG1 Q96BZ83EBI-12030590, EBI-726510
BINARY Q9H0C1LMO2 P25791-33EBI-12030590, EBI-11959475
BINARY Q9H0C1LMO4 P619683EBI-12030590, EBI-2798728
BINARY Q9H0C1MAD2L2 Q9UI953EBI-12030590, EBI-77889
BINARY Q9H0C1MNS1 Q8NEH63EBI-12030590, EBI-743811
BINARY Q9H0C1MOAP1 Q96BY25EBI-12030590, EBI-739825
BINARY Q9H0C1MSGN1 A6NI155EBI-12030590, EBI-11991020
BINARY Q9H0C1MSRB3 Q8IXL7-23EBI-12030590, EBI-10699187
BINARY Q9H0C1NAB2 Q157423EBI-12030590, EBI-8641936
BINARY Q9H0C1NUDT22 Q9BRQ35EBI-12030590, EBI-10297093
BINARY Q9H0C1ONECUT3 O604223EBI-12030590, EBI-17431136
BINARY Q9H0C1PATL1 Q86TB93EBI-12030590, EBI-2562092
BINARY Q9H0C1PICK1 Q9NRD53EBI-12030590, EBI-79165
BINARY Q9H0C1POM121 Q96HA1-23EBI-12030590, EBI-11956563
BINARY Q9H0C1POU6F2 P784243EBI-12030590, EBI-12029004
BINARY Q9H0C1PPP1R18 Q6NYC83EBI-12030590, EBI-2557469
BINARY Q9H0C1PRKAA2 P546463EBI-12030590, EBI-1383852
BINARY Q9H0C1PRR35 P0CG203EBI-12030590, EBI-11986293
BINARY Q9H0C1PRR5-ARHGAP8 B1AHC33EBI-12030590, EBI-17437404
BINARY Q9H0C1PRR5L Q6MZQ03EBI-12030590, EBI-1567866
BINARY Q9H0C1PSMB8 P28062-23EBI-12030590, EBI-372312
BINARY Q9H0C1QARS1 P478975EBI-12030590, EBI-347462
BINARY Q9H0C1RIPPLY1 Q0D2K33EBI-12030590, EBI-10226430
BINARY Q9H0C1RUSC1 Q9BVN25EBI-12030590, EBI-6257312
BINARY Q9H0C1SAMD11 Q96NU13EBI-12030590, EBI-14067109
BINARY Q9H0C1SAXO1 Q8IYX73EBI-12030590, EBI-3957636
BINARY Q9H0C1SAXO4 Q7Z5V6-23EBI-12030590, EBI-12000762
BINARY Q9H0C1SCNM1 Q9BWG63EBI-12030590, EBI-748391
BINARY Q9H0C1SDCBP O005603EBI-12030590, EBI-727004
BINARY Q9H0C1SEC14L4 Q9UDX33EBI-12030590, EBI-10320311
BINARY Q9H0C1SH2D4A Q9H7883EBI-12030590, EBI-747035
BINARY Q9H0C1SHC3 Q925293EBI-12030590, EBI-79084
BINARY Q9H0C1SMARCD1 Q96GM53EBI-12030590, EBI-358489
BINARY Q9H0C1SMG9 Q9H0W83EBI-12030590, EBI-2872322
BINARY Q9H0C1SOHLH1 Q5JUK23EBI-12030590, EBI-12288855
BINARY Q9H0C1SPG21 Q9NZD85EBI-12030590, EBI-742688
BINARY Q9H0C1SPRED1 Q7Z6993EBI-12030590, EBI-5235340
BINARY Q9H0C1STRA8 Q7Z7C73EBI-12030590, EBI-12036261
BINARY Q9H0C1TEKT4 Q8WW243EBI-12030590, EBI-750487
BINARY Q9H0C1TEKT5 Q96M295EBI-12030590, EBI-10239812
BINARY Q9H0C1TEPSIN Q96N213EBI-12030590, EBI-11139477
BINARY Q9H0C1TFAP2D Q7Z6R93EBI-12030590, EBI-11952651
BINARY Q9H0C1THOC1 Q96FV93EBI-12030590, EBI-1765605
BINARY Q9H0C1THRSP Q927483EBI-12030590, EBI-1749955
BINARY Q9H0C1TLE5 Q08117-23EBI-12030590, EBI-11741437
BINARY Q9H0C1TSEN54 Q7Z6J93EBI-12030590, EBI-2559824
BINARY Q9H0C1TSSK3 Q96PN83EBI-12030590, EBI-3918381
BINARY Q9H0C1TTC29 Q8TC835EBI-12030590, EBI-14887934
BINARY Q9H0C1TXN2 Q997573EBI-12030590, EBI-2932492
BINARY Q9H0C1TYMP P199713EBI-12030590, EBI-2556931
BINARY Q9H0C1UNC5CL Q8IV455EBI-12030590, EBI-12238241
BINARY Q9H0C1VEZF1 Q141193EBI-12030590, EBI-11980193
BINARY Q9H0C1VPS37C A5D8V63EBI-12030590, EBI-2559305
BINARY Q9H0C1ZNF148 Q9UQR1-23EBI-12030590, EBI-11742222
BINARY Q9H0C1ZNF414 Q96IQ93EBI-12030590, EBI-744257

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger, repeat.

TypeIDPosition(s)Description
Zinc finger17-54MYND-type; atypical
Repeat172-205TPR 1
Repeat214-247TPR 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    41,818
  • Last updated
    2011-02-08 v3
  • Checksum
    3974C5C55D0A2302
MNVIYPLAVPKGRRLCCEVCEAPAERVCAACTVTYYCGVVHQKADWDSIHEKICQLLIPLRTSMPFYNSEEERQHGLQQLQQRQKYLIEFCYTIAQKYLFEGKHEDAVPAALQSLRFRVKLYGLSSVELVPAYLLLAEASLGLGRIVQAEEYLFQAQWTVLKSTDCSNATHSLLHRNLGLLYIAKKNYEEARYHLANDIYFASCAFGTEDIRTSGGYFHLANIFYDLKKLDLADTLYTKVSEIWHAYLNNHYQVLSQAHIQQMDLLGKLFENDTGLDEAQEAEAIRILTSILNIRESTSDKAPQKTIFVLKILVMFYYLMMNSSKAQEYGMRALSLAKEQQLDVHEQSTIQELLSLISTEDHPIT

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087WUN3A0A087WUN3_HUMANZMYND12125
A0A087WZE7A0A087WZE7_HUMANZMYND1244

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict134in Ref. 1; CAB66792
Sequence conflict166in Ref. 2; BAB71461

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL136858
EMBL· GenBank· DDBJ
CAB66792.1
EMBL· GenBank· DDBJ
mRNA
AK057384
EMBL· GenBank· DDBJ
BAB71461.1
EMBL· GenBank· DDBJ
mRNA
AL513331
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL445669
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC024186
EMBL· GenBank· DDBJ
AAH24186.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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