Q9H094 · NBPF3_HUMAN

  • Protein
    Neuroblastoma breakpoint family member 3
  • Gene
    NBPF3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neuroblastoma breakpoint family member 3
  • Alternative names
    • Protein AE2
    • Protein SHIIIa4

Gene names

    • Name
      NBPF3
    • ORF names
      L7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H094
  • Secondary accessions
    • A8K965
    • B4DSP2
    • I3L0I8
    • Q3BBW1
    • Q5VTG2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_032374114in dbSNP:rs1827293
Natural variantVAR_053909198in dbSNP:rs16825377
Natural variantVAR_047965444in dbSNP:rs12043777
Natural variantVAR_032375459in dbSNP:rs12034222

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 758 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002880381-633Neuroblastoma breakpoint family member 3

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in testis and fetal heart, as well as in non small cell lung carcinoma and neuroblastoma cell line.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, coiled coil, domain, compositional bias.

TypeIDPosition(s)Description
Region15-52Disordered
Coiled coil127-186
Domain221-313Olduvai 1
Domain314-402Olduvai 2
Compositional bias316-338Basic and acidic residues
Region316-370Disordered
Domain405-460Olduvai 3
Domain461-552Olduvai 4
Region463-484Disordered
Domain555-633Olduvai 5

Sequence similarities

Belongs to the NBPF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q9H094-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    633
  • Mass (Da)
    72,951
  • Last updated
    2001-03-01 v1
  • Checksum
    54B627C8AACB0187
MPLTPTVQGFQWTLRGPDVETSPFGAPRAASHGVGRHQELRDPTVPGPTSSATNVSMVVSAGPWSGEKAEMNILEINKKSRPQLAENKQQFRNLKQKCLVTQVAYFLANRQNNYDYEDCKDLIKSMLRDERLLTEEKLAEELGQAEELRQYKVLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQHLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSLEECAITCSNSHHPCESNQPYGNTRITFEEDQVDSTLIDSSSHDEWLDAVCIIPENESDHEQEEEKGPVSPRNLQESEEEEAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSVEEQQVGLALDIGRHWCDQVKKEDQEATSPRLSRELLDEKEPEVLQDSLDRFYSTPFEYLELPDLCQPYRSDFYSLQEQHLGLALDLDRMKKDQEEEEDQGPPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLDRCYSTTSTYFQLHASFQQYRSAFYSFEEQDVSLALDVDNRFFTLTVIRHHLAFQMGVIFPH

Q9H094-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9H094-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9H094-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9H094-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
X6RCV0X6RCV0_HUMANNBPF353
A0A087WUB7A0A087WUB7_HUMANNBPF353
A0A087WUY9A0A087WUY9_HUMANNBPF346

Sequence caution

The sequence AAH24011.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0256261-56in isoform 2
Alternative sequenceVSP_0256251-358in isoform 4
Alternative sequenceVSP_04470545-114in isoform 5
Sequence conflict70in Ref. 2; AAX85103
Sequence conflict78in Ref. 2; AAX85103
Sequence conflict263in Ref. 7; AAH24011
Compositional bias316-338Basic and acidic residues
Alternative sequenceVSP_025627331in isoform 3
Alternative sequenceVSP_025628350-386in isoform 3
Sequence conflict429-430in Ref. 4; BAG61704 and 7; AAH24011
Sequence conflict548in Ref. 4; BAG61704, 5; CAD38998 and 7; AAH24011
Sequence conflict564in Ref. 5; CAD38998

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY598326
EMBL· GenBank· DDBJ
AAT06737.1
EMBL· GenBank· DDBJ
mRNA
AF379629
EMBL· GenBank· DDBJ
AAO15397.1
EMBL· GenBank· DDBJ
mRNA
AY894564
EMBL· GenBank· DDBJ
AAX85103.1
EMBL· GenBank· DDBJ
mRNA
AK292580
EMBL· GenBank· DDBJ
BAF85269.1
EMBL· GenBank· DDBJ
mRNA
AK299840
EMBL· GenBank· DDBJ
BAG61704.1
EMBL· GenBank· DDBJ
mRNA
AL136890
EMBL· GenBank· DDBJ
CAB66824.1
EMBL· GenBank· DDBJ
mRNA
AL834330
EMBL· GenBank· DDBJ
CAD38998.2
EMBL· GenBank· DDBJ
mRNA
AL592309
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC024011
EMBL· GenBank· DDBJ
AAH24011.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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