Q9GZX5 · ZN350_HUMAN
- ProteinZinc finger protein 350
- GeneZNF350
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids532 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear body | |
Cellular Component | nuclear matrix | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | transcription repressor complex | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence IQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDI, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 350
- Alternative names
Gene names
- Community suggested namesZNF350
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9GZX5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Associated with the nuclear matrix.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_046718 | 37 | in dbSNP:rs4987241 | |||
Sequence: M → I | ||||||
Natural variant | VAR_019902 | 66 | in dbSNP:rs2278420 | |||
Sequence: L → P | ||||||
Natural variant | VAR_046719 | 69 | in dbSNP:rs4987042 | |||
Sequence: I → T | ||||||
Natural variant | VAR_046720 | 132 | in dbSNP:rs28997584 | |||
Sequence: R → C | ||||||
Natural variant | VAR_046721 | 406 | in dbSNP:rs3764539 | |||
Sequence: E → K | ||||||
Natural variant | VAR_019903 | 472 | in dbSNP:rs4986771 | |||
Sequence: S → P | ||||||
Natural variant | VAR_019904 | 501 | in dbSNP:rs2278415 | |||
Sequence: R → S | ||||||
Natural variant | VAR_019905 | 524 | in dbSNP:rs4988337 | |||
Sequence: V → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 545 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000047546 | 1-532 | UniProt | Zinc finger protein 350 | |||
Sequence: MIQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKPCHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGNGDSFLHANHERLHTAIKFPASQKLISTKSQFISPKHQKTRKLEKHHVCSECGKAFIKKSWLTDHQVMHTGEKPHRCSLCEKAFSRKFMLTEHQRTHTGEKPYECPECGKAFLKKSRLNIHQKTHTGEKPYICSECGKGFIQKGNLIVHQRIHTGEKPYICNECGKGFIQKTCLIAHQRFHTGKTPFVCSECGKSCSQKSGLIKHQRIHTGEKPFECSECGKAFSTKQKLIVHQRTHTGERPYGCNECGKAFAYMSCLVKHKRIHTREKQEAAKVENPPAERHSSLHTSDVMQEKNSANGATTQVPSVAPQTSLNISGLLANRNVVLVGQPVVRCAASGDNRGFAQDRNLVNAVNVVVPSVINYVLFYVTENP | |||||||
Modified residue (large scale data) | 283 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with BRCA1. Interacts with RNF11.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9GZX5 | BRCA1 P38398 | 3 | EBI-396421, EBI-349905 | |
BINARY | Q9GZX5 | TRIM28 Q13263 | 2 | EBI-396421, EBI-78139 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, zinc finger, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-79 | KRAB | ||||
Sequence: ITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACS | ||||||
Zinc finger | 206-228 | C2H2-type 1 | ||||
Sequence: HVCSECGKAFIKKSWLTDHQVMH | ||||||
Zinc finger | 234-256 | C2H2-type 2 | ||||
Sequence: HRCSLCEKAFSRKFMLTEHQRTH | ||||||
Zinc finger | 262-284 | C2H2-type 3 | ||||
Sequence: YECPECGKAFLKKSRLNIHQKTH | ||||||
Zinc finger | 290-312 | C2H2-type 4 | ||||
Sequence: YICSECGKGFIQKGNLIVHQRIH | ||||||
Zinc finger | 318-340 | C2H2-type 5 | ||||
Sequence: YICNECGKGFIQKTCLIAHQRFH | ||||||
Zinc finger | 346-368 | C2H2-type 6 | ||||
Sequence: FVCSECGKSCSQKSGLIKHQRIH | ||||||
Zinc finger | 374-396 | C2H2-type 7 | ||||
Sequence: FECSECGKAFSTKQKLIVHQRTH | ||||||
Zinc finger | 402-424 | C2H2-type 8 | ||||
Sequence: YGCNECGKAFAYMSCLVKHKRIH | ||||||
Compositional bias | 427-448 | Basic and acidic residues | ||||
Sequence: EKQEAAKVENPPAERHSSLHTS | ||||||
Region | 427-465 | Disordered | ||||
Sequence: EKQEAAKVENPPAERHSSLHTSDVMQEKNSANGATTQVP | ||||||
Compositional bias | 449-465 | Polar residues | ||||
Sequence: DVMQEKNSANGATTQVP |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length532
- Mass (Da)60,011
- Last updated2010-11-30 v3
- ChecksumFEF12A92F95BAC8A
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 427-448 | Basic and acidic residues | ||||
Sequence: EKQEAAKVENPPAERHSSLHTS | ||||||
Compositional bias | 449-465 | Polar residues | ||||
Sequence: DVMQEKNSANGATTQVP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF295096 EMBL· GenBank· DDBJ | AAG17439.1 EMBL· GenBank· DDBJ | mRNA | ||
AF309561 EMBL· GenBank· DDBJ | AAG25714.1 EMBL· GenBank· DDBJ | mRNA | ||
AK023467 EMBL· GenBank· DDBJ | BAB14583.1 EMBL· GenBank· DDBJ | mRNA | ||
AC011460 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471135 EMBL· GenBank· DDBJ | EAW72056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC009921 EMBL· GenBank· DDBJ | AAH09921.1 EMBL· GenBank· DDBJ | mRNA |