Q9GZX5 · ZN350_HUMAN

  • Protein
    Zinc finger protein 350
  • Gene
    ZNF350
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear body
Cellular Componentnuclear matrix
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription repressor complex
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

The subsequence IQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDI, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 350
  • Alternative names
    • KRAB zinc finger protein ZFQR
    • Zinc finger and BRCA1-interacting protein with a KRAB domain 1
    • Zinc finger protein ZBRK1

Gene names

    • Name
      ZNF350
    • Synonyms
      ZBRK1
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9GZX5
  • Secondary accessions
    • Q96G73
    • Q9HAQ4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04671837in dbSNP:rs4987241
Natural variantVAR_01990266in dbSNP:rs2278420
Natural variantVAR_04671969in dbSNP:rs4987042
Natural variantVAR_046720132in dbSNP:rs28997584
Natural variantVAR_046721406in dbSNP:rs3764539
Natural variantVAR_019903472in dbSNP:rs4986771
Natural variantVAR_019904501in dbSNP:rs2278415
Natural variantVAR_019905524in dbSNP:rs4988337

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 545 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000475461-532UniProtZinc finger protein 350
Modified residue (large scale data)283PRIDEPhosphothreonine

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with BRCA1. Interacts with RNF11.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9GZX5BRCA1 P383983EBI-396421, EBI-349905
BINARY Q9GZX5TRIM28 Q132632EBI-396421, EBI-78139

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, zinc finger, compositional bias, region.

TypeIDPosition(s)Description
Domain8-79KRAB
Zinc finger206-228C2H2-type 1
Zinc finger234-256C2H2-type 2
Zinc finger262-284C2H2-type 3
Zinc finger290-312C2H2-type 4
Zinc finger318-340C2H2-type 5
Zinc finger346-368C2H2-type 6
Zinc finger374-396C2H2-type 7
Zinc finger402-424C2H2-type 8
Compositional bias427-448Basic and acidic residues
Region427-465Disordered
Compositional bias449-465Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    532
  • Mass (Da)
    60,011
  • Last updated
    2010-11-30 v3
  • Checksum
    FEF12A92F95BAC8A
MIQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKPCHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGNGDSFLHANHERLHTAIKFPASQKLISTKSQFISPKHQKTRKLEKHHVCSECGKAFIKKSWLTDHQVMHTGEKPHRCSLCEKAFSRKFMLTEHQRTHTGEKPYECPECGKAFLKKSRLNIHQKTHTGEKPYICSECGKGFIQKGNLIVHQRIHTGEKPYICNECGKGFIQKTCLIAHQRFHTGKTPFVCSECGKSCSQKSGLIKHQRIHTGEKPFECSECGKAFSTKQKLIVHQRTHTGERPYGCNECGKAFAYMSCLVKHKRIHTREKQEAAKVENPPAERHSSLHTSDVMQEKNSANGATTQVPSVAPQTSLNISGLLANRNVVLVGQPVVRCAASGDNRGFAQDRNLVNAVNVVVPSVINYVLFYVTENP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0R017M0R017_HUMANZNF350163
M0R1T8M0R1T8_HUMANZNF35052
M0QY52M0QY52_HUMANZNF35067
M0QYT6M0QYT6_HUMANZNF35062

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias427-448Basic and acidic residues
Compositional bias449-465Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF295096
EMBL· GenBank· DDBJ
AAG17439.1
EMBL· GenBank· DDBJ
mRNA
AF309561
EMBL· GenBank· DDBJ
AAG25714.1
EMBL· GenBank· DDBJ
mRNA
AK023467
EMBL· GenBank· DDBJ
BAB14583.1
EMBL· GenBank· DDBJ
mRNA
AC011460
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471135
EMBL· GenBank· DDBJ
EAW72056.1
EMBL· GenBank· DDBJ
Genomic DNA
BC009921
EMBL· GenBank· DDBJ
AAH09921.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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