Q9GYZ0 · KIF15_STRPU
- ProteinKinesin-like protein KIF15
- GeneKIF15
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1463 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Plays a role in positioning spindle poles during mitosis, specifically at prometaphase.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | kinesin complex | |
Cellular Component | microtubule | |
Cellular Component | spindle pole | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Molecular Function | plus-end-directed microtubule motor activity | |
Biological Process | centrosome separation | |
Biological Process | microtubule-based movement | |
Biological Process | mitotic spindle assembly |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameKinesin-like protein KIF15
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Camarodonta > Echinidea > Strongylocentrotidae > Strongylocentrotus
Accessions
- Primary accessionQ9GYZ0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes at the central spindle.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000328687 | 1-1463 | Kinesin-like protein KIF15 | |||
Sequence: MSKKLKEQAANDASEGDAIKVFVRVRPSESHDADAAFGQCLEVRLPDTIIMHSKPEPKVFTYDHVTAANTTQESVFTAVGKRIIESCVGGFNGTIFAYGQTGSGKTFTMLGPCEDGDNFHHEMRGVIPRSFEYLFSLVNREREKHGDRYEFLCRCSFLEIYNEQIYDLLDPASLGLHLRENMKKGVFVDGLIERAVASASEAYGVLQAGWHNRRVAATSMNRESSRSHAVFTVSIESKEKKAGVSNIRVSQLHLVDLAGSERQKDTKAIGVRLKEAGSINKSLSILGNVIMALVDIAHGKQRHVPYRDSKLSFLLRDSLGGNAKTYIIANVHPDAKCFGETLSTLKFARRAKMIKNRAVVNEDTQGNVMHLQAEIRRLREALCMKGAEGSIPRGPSESGDSQMSNSSTESNGPVSGQQSGSSSSSKWKKYFLEAMSLRDIVEVEKREMREKVSSLEELCSKRDQVISSNKMIIKFRNSTIDMLQKTKNKALLKEDRDLLNENLKKEIEQLQEQLEHNPFVMRYVVENQSLRAQNKKLKMMEAVRSGEAMAATKAEELETLFLELREGLSKNRRYSSTPVDGEKVPTSTLVILKSQIKKLQDELENAKQEHAEQEEMTRTTRLDLESELAAYKKANLDMEKTLQGMKIKNRMDRDAMNDIHMQTIKSITTPKKVTYQLRSRTVLRTAGEETPGGPGFAGLSDNGSPLRSHSTNSLPPSGDILVTNSSPAMSEEGIIDEEMPEHVIEQCNEALTIELQKLQDKNANLQQQLEEHESQKHKMLQNSSKLDHQLQQITELYSTESQAWQEHEKDLTTRLAEATIQISTLQRDYEMTRGEAEDFKVMLQAADKEIGQEKKQKSKVTQDWDRVRAALDAQVVRLENEMCGQSRELENLTEDREQLQDAYNTLQAEHEFQQQREADLENRLKGKKAEITQLQEEIQKHLEKLDSERDKSMRLTAELRQGDNTKKDLLDAQELIDQFREERDDLLHRLDTEALKLSSSKEDLETVNSALTAIKKTDVEQKEALSSLMAALQGQKGMVKDKEEQLASMQMQLEDTRGQVSLLEAALEEGKASGAGLQSQIAALEDRMHAQAGEYQEQIEQMRADAMDANQHQKELLKELEKQSEELTQLHKQMKEKEEEYETKESEHKDTIESLEEQLEEVKTNLSTVVVELDEPESKKRKMADAQAMEIESLRDSEKRFKELSSVYDNMRDQMNEEIRSLKMKADELEDVRISKEILQAQHTALTYEIEQVRNEMAEKESSLKDEVNHLKRDMERQKTVLASMLRDKDEAVEKLYTVQTTLDQVKANEEILQENMDQVMEELDRTSALESTHFKEKEDIKSKLEEEREEKSKLTKDLTRLKEVYEEAEKKITELGGHQNPKQKIHHLQAVKSENYFLKEEVESLEKQLGKAQSDSEQMKRDYEALQKRLTSSSAEPPEEAGATTCIRCLPHSKRIMQTQTA |
Expression
Developmental stage
Expressed in eggs.
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-354 | Kinesin motor | ||||
Sequence: AIKVFVRVRPSESHDADAAFGQCLEVRLPDTIIMHSKPEPKVFTYDHVTAANTTQESVFTAVGKRIIESCVGGFNGTIFAYGQTGSGKTFTMLGPCEDGDNFHHEMRGVIPRSFEYLFSLVNREREKHGDRYEFLCRCSFLEIYNEQIYDLLDPASLGLHLRENMKKGVFVDGLIERAVASASEAYGVLQAGWHNRRVAATSMNRESSRSHAVFTVSIESKEKKAGVSNIRVSQLHLVDLAGSERQKDTKAIGVRLKEAGSINKSLSILGNVIMALVDIAHGKQRHVPYRDSKLSFLLRDSLGGNAKTYIIANVHPDAKCFGETLSTLKFARRAKMI | ||||||
Region | 387-424 | Disordered | ||||
Sequence: AEGSIPRGPSESGDSQMSNSSTESNGPVSGQQSGSSSS | ||||||
Compositional bias | 395-424 | Polar residues | ||||
Sequence: PSESGDSQMSNSSTESNGPVSGQQSGSSSS | ||||||
Coiled coil | 436-517 | |||||
Sequence: SLRDIVEVEKREMREKVSSLEELCSKRDQVISSNKMIIKFRNSTIDMLQKTKNKALLKEDRDLLNENLKKEIEQLQEQLEHN | ||||||
Coiled coil | 586-646 | |||||
Sequence: TSTLVILKSQIKKLQDELENAKQEHAEQEEMTRTTRLDLESELAAYKKANLDMEKTLQGMK | ||||||
Region | 686-720 | Disordered | ||||
Sequence: AGEETPGGPGFAGLSDNGSPLRSHSTNSLPPSGDI | ||||||
Compositional bias | 703-720 | Polar residues | ||||
Sequence: GSPLRSHSTNSLPPSGDI | ||||||
Region | 1335-1356 | Disordered | ||||
Sequence: FKEKEDIKSKLEEEREEKSKLT | ||||||
Compositional bias | 1409-1428 | Basic and acidic residues | ||||
Sequence: QLGKAQSDSEQMKRDYEALQ | ||||||
Region | 1409-1444 | Disordered | ||||
Sequence: QLGKAQSDSEQMKRDYEALQKRLTSSSAEPPEEAGA |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,463
- Mass (Da)166,590
- Last updated2001-03-01 v1
- Checksum1E8BFC2BB5AEF94D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 395-424 | Polar residues | ||||
Sequence: PSESGDSQMSNSSTESNGPVSGQQSGSSSS | ||||||
Compositional bias | 703-720 | Polar residues | ||||
Sequence: GSPLRSHSTNSLPPSGDI | ||||||
Compositional bias | 1409-1428 | Basic and acidic residues | ||||
Sequence: QLGKAQSDSEQMKRDYEALQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF284333 EMBL· GenBank· DDBJ | AAG01844.1 EMBL· GenBank· DDBJ | mRNA |