Q9GPG2 · Q9GPG2_CALSI

Function

function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmetal ion binding
Molecular FunctionP-type sodium:potassium-exchanging transporter activity
Biological Processintracellular potassium ion homeostasis
Biological Processintracellular sodium ion homeostasis
Biological Processpotassium ion import across plasma membrane
Biological Processproton transmembrane transport
Biological Processsodium ion export across plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/potassium-transporting ATPase subunit alpha

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Brachyura > Eubrachyura > Portunoidea > Portunidae > Portuninae > Callinectes

Accessions

  • Primary accession
    Q9GPG2

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane112-133Helical
Transmembrane145-165Helical
Transmembrane307-331Helical
Transmembrane337-360Helical
Transmembrane869-888Helical
Transmembrane929-948Helical
Transmembrane969-989Helical
Transmembrane1001-1017Helical

Keywords

  • Cellular component

Interaction

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-31Basic and acidic residues
Region1-51Disordered
Domain58-132Cation-transporting P-type ATPase N-terminal

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,039
  • Mass (Da)
    115,626
  • Last updated
    2001-03-01 v1
  • Checksum
    EBB3AB138CCD4576
MADTGRTDSYRHATDRNIPDDNRTVKGDPKSKKKNVKGKRKGEKEKDMDNLKQELELDEHKVPIEELFQRLSVNPDTGLTQAEARRRLERDGPNALTPPKQTPEWVKFCKNLFGGFSLLLWIGAILCFIAYSIEAASEEEPNNDNLYLGIVLTAVVIITGIFSYYQESKSSRIMESFKNLVPQYAIVIREGEKLNVQAEELCIGDIIDVKFGDRIPADMRVIEARGFKVDNSSLTGESEPQSRSPEFTSENPLETKNLAFFSTNAVEGTCKGIVINIGDNTVMGRIAGLASGLETGETPIAKEISHFIHIITGVAVFLGVTFFVIAFIMGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMAAKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNTIIEADTSEDQSGCQYDKTSDGWKALSRIAALCNRAEFKTGQEDVPILKREVNGDASEAALLKCVELAIGDVRGWRSRNKKVCEIPFNSTNKYQVSIHETQDKNDLRYLLVMKGAPERILERCSTIFMNGEEKPLDEEMKESFNNAYLELGGLGERVLGFCDYVLPSDKYPLGYPFDADAVNFPVHGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPIKEVDPREAKAAVVHGSELRDMTSEQLDDVLIHHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFMIASVPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRNPFTDKLVNERLISMAYGQIGMIQALAGFYVYFVIMAENGFLPPVLFGIREQWDSKAINDLEDYYGQEWTYHDRKILEYTCHTAFFVAIVVVQWADLIICKTRRNSILHQGMKNMVLNFGLCFETTLAAFLSYTPGMDKGLRMYPLKFYWWLPPLPFSLLIFVYDECRRFVLRRNPGGWVEMETYY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-31Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF327439
EMBL· GenBank· DDBJ
AAG47843.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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