Q9GLN9 · AGTR1_PANTR
- ProteinType-1 angiotensin II receptor
- GeneAGTR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids359 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca2+ concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 15 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 17 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 167 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 182 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 183 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 184 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 199 | angiotensin II (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | angiotensin type I receptor activity | |
Molecular Function | angiotensin type II receptor activity | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | inflammatory response | |
Biological Process | maintenance of blood vessel diameter homeostasis by renin-angiotensin | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | regulation of vasoconstriction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameType-1 angiotensin II receptor
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionQ9GLN9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-25 | Extracellular | ||||
Sequence: MILNSSTEDGIKRIQDDCPKAGRHN | ||||||
Transmembrane | 26-55 | Helical; Name=1 | ||||
Sequence: YIFVMIPTLYSIIFVVGIFGNSLVVIVIYF | ||||||
Topological domain | 56-61 | Cytoplasmic | ||||
Sequence: YMKLKT | ||||||
Transmembrane | 62-89 | Helical; Name=2 | ||||
Sequence: VASVFLLNLALADLCFLLTLPLWAVYTA | ||||||
Topological domain | 90-98 | Extracellular | ||||
Sequence: MEYRWPFGN | ||||||
Transmembrane | 99-125 | Helical; Name=3 | ||||
Sequence: YLCKIASASVSFNLYASVFLLTCLSID | ||||||
Topological domain | 126-141 | Cytoplasmic | ||||
Sequence: RYLAIVHPMKSRLRRT | ||||||
Transmembrane | 142-165 | Helical; Name=4 | ||||
Sequence: MLVAKVTCIIIWLLAGLASLPAII | ||||||
Topological domain | 166-190 | Extracellular | ||||
Sequence: HRNVFFIENTNITVCAFHYESQNST | ||||||
Transmembrane | 191-216 | Helical; Name=5 | ||||
Sequence: LPIGLGLTKNILGFLFPFLIILTSYT | ||||||
Topological domain | 217-239 | Cytoplasmic | ||||
Sequence: LIWKALKKAYEIQKNKPRNDDIF | ||||||
Transmembrane | 240-268 | Helical; Name=6 | ||||
Sequence: KIIMAIVLFFFFSWIPHQIFTFLDVLIQL | ||||||
Topological domain | 269-278 | Extracellular | ||||
Sequence: GIIRDCRIAD | ||||||
Transmembrane | 279-304 | Helical; Name=7 | ||||
Sequence: IVDTAMPITICIAYFNNCLNPLFYGF | ||||||
Topological domain | 305-359 | Cytoplasmic | ||||
Sequence: LGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069157 | 1-359 | Type-1 angiotensin II receptor | |||
Sequence: MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 18↔274 | |||||
Sequence: CPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDC | ||||||
Disulfide bond | 101↔180 | |||||
Sequence: CKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC | ||||||
Glycosylation | 176 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 188 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 355 | S-palmitoyl cysteine | ||||
Sequence: C |
Post-translational modification
C-terminal Ser or Thr residues may be phosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with MAS1 (By similarity).
Interacts with ARRB1 (By similarity).
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
Interacts with ARRB1 (By similarity).
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 335-351 | Polar residues | ||||
Sequence: STLSYRPSDNVSSSTKK | ||||||
Region | 335-359 | Disordered | ||||
Sequence: STLSYRPSDNVSSSTKKPAPCFEVE |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length359
- Mass (Da)41,033
- Last updated2001-03-01 v1
- Checksum266133A7A3E911A6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 335-351 | Polar residues | ||||
Sequence: STLSYRPSDNVSSSTKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF193445 EMBL· GenBank· DDBJ | AAG28410.1 EMBL· GenBank· DDBJ | Genomic DNA |