Q9GLK4 · ANFB_FELCA

Function

function

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity).
May also function as a paracrine antifibrotic factor in the heart (By similarity).
Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).

Features

Showing features for site.

1132102030405060708090100110120130
TypeIDPosition(s)Description
Site97-98Cleavage; by CORIN or FURIN
Site102-103Cleavage; by FAP
Site103-104Cleavage; by CORIN

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular Functionhormone activity
Molecular Functionhormone receptor binding
Biological Processblood vessel diameter maintenance
Biological ProcesscGMP biosynthetic process
Biological ProcesscGMP-mediated signaling
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processneuropeptide signaling pathway
Biological Processreceptor guanylyl cyclase signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Natriuretic peptides B
  • Alternative names
    • Brain natriuretic factor prohormone
      (preproBNP
      ; proBNP
      )
    • Gamma-brain natriuretic peptide
    • Iso-ANP
  • Cleaved into 2 chains

Gene names

    • Name
      NPPB
    • Synonyms
      BNP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    Q9GLK4

Proteomes

Subcellular Location

Secreted
Note: Detected in blood.

Keywords

PTM/Processing

Features

Showing features for signal, chain, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000000152927-132Natriuretic peptides B
PeptidePRO_000045193798-132Brain natriuretic peptide 35
PeptidePRO_0000451938104-132Brain natriuretic peptide 29
Disulfide bond110↔126

Post-translational modification

The precursor molecule is proteolytically cleaved, possibly by FURIN or CORIN, to produce the active peptide (By similarity).
May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity).
May be cleaved at Ser-102 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity).
May be degraded by IDE (By similarity).
During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region62-87Disordered

Sequence similarities

Belongs to the natriuretic peptide family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    132
  • Mass (Da)
    14,344
  • Last updated
    2001-03-01 v1
  • Checksum
    D069B5F76A6C3510
MDPKTALLRALLLLLFLHLSPLGGRSHPLGGPGPASEASAIQELLDGLRDTVSELQEAQMALGPLQQGHSPAESWEAQEEPPARVLAPHDNVLRALRRLGSSKMMRDSRCFGRRLDRIGSLSGLGCNVLRRH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF253495
EMBL· GenBank· DDBJ
AAG13661.1
EMBL· GenBank· DDBJ
mRNA
AF425738
EMBL· GenBank· DDBJ
AAL24812.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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