Q9GLK4 · ANFB_FELCA
- ProteinNatriuretic peptides B
- GeneNPPB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids132 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity).
May also function as a paracrine antifibrotic factor in the heart (By similarity).
Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).
May also function as a paracrine antifibrotic factor in the heart (By similarity).
Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 97-98 | Cleavage; by CORIN or FURIN | ||||
Sequence: RR | ||||||
Site | 102-103 | Cleavage; by FAP | ||||
Sequence: SK | ||||||
Site | 103-104 | Cleavage; by CORIN | ||||
Sequence: KM |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | hormone activity | |
Molecular Function | hormone receptor binding | |
Biological Process | blood vessel diameter maintenance | |
Biological Process | cGMP biosynthetic process | |
Biological Process | cGMP-mediated signaling | |
Biological Process | negative regulation of systemic arterial blood pressure | |
Biological Process | neuropeptide signaling pathway | |
Biological Process | receptor guanylyl cyclase signaling pathway |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNatriuretic peptides B
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionQ9GLK4
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, peptide, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MDPKTALLRALLLLLFLHLSPLGGRS | ||||||
Chain | PRO_0000001529 | 27-132 | Natriuretic peptides B | |||
Sequence: HPLGGPGPASEASAIQELLDGLRDTVSELQEAQMALGPLQQGHSPAESWEAQEEPPARVLAPHDNVLRALRRLGSSKMMRDSRCFGRRLDRIGSLSGLGCNVLRRH | ||||||
Peptide | PRO_0000451937 | 98-132 | Brain natriuretic peptide 35 | |||
Sequence: RLGSSKMMRDSRCFGRRLDRIGSLSGLGCNVLRRH | ||||||
Peptide | PRO_0000451938 | 104-132 | Brain natriuretic peptide 29 | |||
Sequence: MMRDSRCFGRRLDRIGSLSGLGCNVLRRH | ||||||
Disulfide bond | 110↔126 | |||||
Sequence: CFGRRLDRIGSLSGLGC |
Post-translational modification
The precursor molecule is proteolytically cleaved, possibly by FURIN or CORIN, to produce the active peptide (By similarity).
May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity).
May be cleaved at Ser-102 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity).
May be degraded by IDE (By similarity).
During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).
May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity).
May be cleaved at Ser-102 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity).
May be degraded by IDE (By similarity).
During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 62-87 | Disordered | ||||
Sequence: LGPLQQGHSPAESWEAQEEPPARVLA |
Sequence similarities
Belongs to the natriuretic peptide family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length132
- Mass (Da)14,344
- Last updated2001-03-01 v1
- ChecksumD069B5F76A6C3510
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF253495 EMBL· GenBank· DDBJ | AAG13661.1 EMBL· GenBank· DDBJ | mRNA | ||
AF425738 EMBL· GenBank· DDBJ | AAL24812.1 EMBL· GenBank· DDBJ | Genomic DNA |