Q9FVZ0 · Q9FVZ0_ORYSJ
- ProteinFolylpolyglutamate synthase
- GeneOSJNBb0073N24.10
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids546 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H+
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:14738 + CHEBI:29985 + CHEBI:30616 = (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n+1) RHEA-COMP:14740 + CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Cofactor
Note: A monovalent cation.
Pathway
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 152 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 221 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 249 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 350 | ATP (UniProtKB | ChEBI) | |||
Binding site | 372 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | tetrahydrofolylpolyglutamate synthase activity | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFolylpolyglutamate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ9FVZ0
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length546
- Mass (Da)60,109
- Last updated2001-03-01 v1
- Checksum673296EE35FA5464
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC078840 EMBL· GenBank· DDBJ | AAG13624.1 EMBL· GenBank· DDBJ | Genomic DNA |