Q9FT81 · TT8_ARATH

Function

function

Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression.

Miscellaneous

TT8 might interact with TT2 and TTG1 to modulate the late genes of the flavonoid pathway.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionprotein dimerization activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processflavonoid biosynthetic process
Biological Processjasmonic acid mediated signaling pathway
Biological Processpositive regulation of anthocyanin biosynthetic process
Biological Processregulation of flavonoid biosynthetic process
Biological Processregulation of proanthocyanidin biosynthetic process
Biological Processseed coat development
Biological Processseed development
Biological Processtrichome differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor TT8
  • Alternative names
    • Basic helix-loop-helix protein 42
      (AtbHLH42
      ; bHLH 42
      )
    • Protein TRANSPARENT TESTA 8
    • Transcription factor EN 32
    • bHLH transcription factor bHLH042

Gene names

    • Name
      TT8
    • Synonyms
      BHLH42
      , EN32
    • ORF names
      F17A8.170
    • Ordered locus names
      At4g09820

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Columbia
    • cv. En-2
    • cv. Wassilewskija-2
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FT81
  • Secondary accessions
    • A0MF61
    • Q1PEA5
    • Q9SZ97

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis, natural variant.

TypeIDPosition(s)Description
Mutagenesis268In tt8-1; loss of seed pigmentation.
Natural variant307in strain: cv. Wassilewskija-2

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 50 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001274311-518Transcription factor TT8

Proteomic databases

Expression

Tissue specificity

Buds, flowers and developing siliques, but not in leaves, stems and roots.

Developmental stage

Faint expression in buds and flowers. Increases during the very early stages of seed development, reaches a maximum at the globular embryo stage and stays high throughout seed formation.

Gene expression databases

Interaction

Subunit

Homodimer (Probable). Interacts with MYB4, MYB5, MYB6, MYB82, MYB113, MYB114, MYB75/PAP1, MYB90/PAP2, and TT2.

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, domain.

TypeIDPosition(s)Description
Coiled coil220-240
Domain359-408bHLH
Coiled coil405-428

Sequence similarities

Belongs to the bHLH protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    518
  • Mass (Da)
    59,198
  • Last updated
    2002-12-13 v2
  • Checksum
    25988482FE25C99C
MDESSIIPAEKVAGAEKKELQGLLKTAVQSVDWTYSVFWQFCPQQRVLVWGNGYYNGAIKTRKTTQPAEVTAEEAALERSQQLRELYETLLAGESTSEARACTALSPEDLTETEWFYLMCVSFSFPPPSGMPGKAYARRKHVWLSGANEVDSKTFSRAILAKSAKIQTVVCIPMLDGVVELGTTKKVREDVEFVELTKSFFYDHCKTNPKPALSEHSTYEVHEEAEDEEEVEEEMTMSEEMRLGSPDDEDVSNQNLHSDLHIESTHTLDTHMDMMNLMEEGGNYSQTVTTLLMSHPTSLLSDSVSTSSYIQSSFATWRVENGKEHQQVKTAPSSQWVLKQMIFRVPFLHDNTKDKRLPREDLSHVVAERRRREKLNEKFITLRSMVPFVTKMDKVSILGDTIAYVNHLRKRVHELENTHHEQQHKRTRTCKRKTSEEVEVSIIENDVLLEMRCEYRDGLLLDILQVLHELGIETTAVHTSVNDHDFEAEIRAKVRGKKASIAEVKRAIHQVIIHDTNL

Sequence caution

The sequence ABK28624.1 differs from that shown. Reason: Erroneous termination Extended C-terminus.
The sequence CAB39649.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB78105.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ277509
EMBL· GenBank· DDBJ
CAC14865.1
EMBL· GenBank· DDBJ
mRNA
AL049482
EMBL· GenBank· DDBJ
CAB39649.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161516
EMBL· GenBank· DDBJ
CAB78105.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE82802.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ446813
EMBL· GenBank· DDBJ
ABE66051.1
EMBL· GenBank· DDBJ
mRNA
DQ653187
EMBL· GenBank· DDBJ
ABK28624.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp