Q9FNY2 · DPB_ARATH

Function

function

Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin.

Features

Showing features for dna binding.

138550100150200250300350
TypeIDPosition(s)Description
DNA binding101-184

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentDRM complex
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Biological ProcessDNA endoreduplication
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processregulation of cell cycle
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor-like protein DPB
  • Alternative names
    • DP-like protein B (AtDPbB)
    • E2F dimerization partner protein B

Gene names

    • Name
      DPB
    • Synonyms
      DP1
    • ORF names
      F12E4.160
    • Ordered locus names
      At5g03415

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FNY2
  • Secondary accessions
    • Q8LDG3
    • Q9LZE7

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004058651-385Transcription factor-like protein DPB

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Developmental stage

Expressed during the whole cell cycle.

Gene expression databases

Interaction

Subunit

Heterodimer with non-phosphorylated E2FC. No interaction with phosphorylated E2FC. Interacts preferentially with E2FC, but also with E2FA and E2FB. Interacts with SKP2A. Targeted for proteasomal degradation by the SCF(SKP2A) E3 ubiquitin ligase complex.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9FNY2E2FA Q9FNY05EBI-1774876, EBI-1774747
BINARY Q9FNY2E2FB Q9FV716EBI-1774876, EBI-1774719

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif, coiled coil.

TypeIDPosition(s)Description
Region1-53Disordered
Region71-102Disordered
Motif150-184DEF box
Coiled coil185-234
Region296-385Disordered

Domain

The DIM domain (182-263) is required for heterodimerization.

Sequence similarities

Belongs to the E2F/DP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9FNY2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    385
  • Mass (Da)
    42,755
  • Last updated
    2001-03-01 v1
  • Checksum
    5DDB4ACA04C52AF8
MTTTGSNSNHNHHESNNNNNNPSTRSWGTAVSGQSVSTSGSMGSPSSRSEQTITVVTSTSDTTFQRLNNLDIQGDDAGSQGASGVKKKKRGQRAAGPDKTGRGLRQFSMKVCEKVESKGRTTYNEVADELVAEFALPNNDGTSPDQQQYDEKNIRRRVYDALNVLMAMDIISKDKKEIQWRGLPRTSLSDIEELKNERLSLRNRIEKKTAYSQELEEQYVGLQNLIQRNEHLYSSGNAPSGGVALPFILVQTRPHATVEVEISEDMQLVHFDFNSTPFELHDDNFVLKTMKFCDQPPQQPNGRNNSQLVCHNFTPENPNKGPSTGPTPQLDMYETHLQSQQHQQHSQLQIIPMPETNNVTSSADTAPVKSPSLPGIMNSSMKPEN

Q9FNY2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence CAB83299.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict40in Ref. 4; AAM63227
Sequence conflict59in Ref. 4; AAM63227
Alternative sequenceVSP_040734105-111in isoform 2
Sequence conflict303in Ref. 4; AAM63227
Sequence conflict375in Ref. 4; AAM63227

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ294532
EMBL· GenBank· DDBJ
CAC15484.1
EMBL· GenBank· DDBJ
mRNA
AL162751
EMBL· GenBank· DDBJ
CAB83299.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED90599.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED90600.1
EMBL· GenBank· DDBJ
Genomic DNA
AY086018
EMBL· GenBank· DDBJ
AAM63227.1
EMBL· GenBank· DDBJ
mRNA
AK228148
EMBL· GenBank· DDBJ
BAF00104.1
EMBL· GenBank· DDBJ
mRNA
AB493733
EMBL· GenBank· DDBJ
BAH30571.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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