Q9FNY2 · DPB_ARATH
- ProteinTranscription factor-like protein DPB
- GeneDPB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids385 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 101-184 | |||||
Sequence: GRGLRQFSMKVCEKVESKGRTTYNEVADELVAEFALPNNDGTSPDQQQYDEKNIRRRVYDALNVLMAMDIISKDKKEIQWRGLP |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | DRM complex | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | protein heterodimerization activity | |
Biological Process | DNA endoreduplication | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscription factor-like protein DPB
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FNY2
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405865 | 1-385 | Transcription factor-like protein DPB | |||
Sequence: MTTTGSNSNHNHHESNNNNNNPSTRSWGTAVSGQSVSTSGSMGSPSSRSEQTITVVTSTSDTTFQRLNNLDIQGDDAGSQGASGVKKKKRGQRAAGPDKTGRGLRQFSMKVCEKVESKGRTTYNEVADELVAEFALPNNDGTSPDQQQYDEKNIRRRVYDALNVLMAMDIISKDKKEIQWRGLPRTSLSDIEELKNERLSLRNRIEKKTAYSQELEEQYVGLQNLIQRNEHLYSSGNAPSGGVALPFILVQTRPHATVEVEISEDMQLVHFDFNSTPFELHDDNFVLKTMKFCDQPPQQPNGRNNSQLVCHNFTPENPNKGPSTGPTPQLDMYETHLQSQQHQQHSQLQIIPMPETNNVTSSADTAPVKSPSLPGIMNSSMKPEN |
Post-translational modification
Phosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous.
Developmental stage
Expressed during the whole cell cycle.
Gene expression databases
Interaction
Subunit
Heterodimer with non-phosphorylated E2FC. No interaction with phosphorylated E2FC. Interacts preferentially with E2FC, but also with E2FA and E2FB. Interacts with SKP2A. Targeted for proteasomal degradation by the SCF(SKP2A) E3 ubiquitin ligase complex.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9FNY2 | E2FA Q9FNY0 | 5 | EBI-1774876, EBI-1774747 | |
BINARY | Q9FNY2 | E2FB Q9FV71 | 6 | EBI-1774876, EBI-1774719 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-53 | Disordered | ||||
Sequence: MTTTGSNSNHNHHESNNNNNNPSTRSWGTAVSGQSVSTSGSMGSPSSRSEQTI | ||||||
Region | 71-102 | Disordered | ||||
Sequence: DIQGDDAGSQGASGVKKKKRGQRAAGPDKTGR | ||||||
Motif | 150-184 | DEF box | ||||
Sequence: DEKNIRRRVYDALNVLMAMDIISKDKKEIQWRGLP | ||||||
Coiled coil | 185-234 | |||||
Sequence: RTSLSDIEELKNERLSLRNRIEKKTAYSQELEEQYVGLQNLIQRNEHLYS | ||||||
Region | 296-385 | Disordered | ||||
Sequence: PPQQPNGRNNSQLVCHNFTPENPNKGPSTGPTPQLDMYETHLQSQQHQQHSQLQIIPMPETNNVTSSADTAPVKSPSLPGIMNSSMKPEN |
Domain
The DIM domain (182-263) is required for heterodimerization.
Sequence similarities
Belongs to the E2F/DP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9FNY2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length385
- Mass (Da)42,755
- Last updated2001-03-01 v1
- Checksum5DDB4ACA04C52AF8
Q9FNY2-2
- Name2
- Differences from canonical
- 105-111: RQFSMKV → L
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 40 | in Ref. 4; AAM63227 | ||||
Sequence: G → S | ||||||
Sequence conflict | 59 | in Ref. 4; AAM63227 | ||||
Sequence: T → A | ||||||
Alternative sequence | VSP_040734 | 105-111 | in isoform 2 | |||
Sequence: RQFSMKV → L | ||||||
Sequence conflict | 303 | in Ref. 4; AAM63227 | ||||
Sequence: R → Q | ||||||
Sequence conflict | 375 | in Ref. 4; AAM63227 | ||||
Sequence: G → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ294532 EMBL· GenBank· DDBJ | CAC15484.1 EMBL· GenBank· DDBJ | mRNA | ||
AL162751 EMBL· GenBank· DDBJ | CAB83299.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED90599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED90600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY086018 EMBL· GenBank· DDBJ | AAM63227.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228148 EMBL· GenBank· DDBJ | BAF00104.1 EMBL· GenBank· DDBJ | mRNA | ||
AB493733 EMBL· GenBank· DDBJ | BAH30571.1 EMBL· GenBank· DDBJ | mRNA |