Q9FNQ4 · PHD4_ARATH

Function

function

Together with AIPP3/BDT1, cooperates to form a BAH-PHD bivalent histone reader complex able to read histone H3 lysine 27 trimethylation (H3K27me3) histone marks in order to regulate transcription, especially to prevent early flowering; promotes AIPP3/BDT1 binding to H3K27me3.

Features

Showing features for binding site.

116120406080100120140160
TypeIDPosition(s)Description
Binding site33Zn2+ 1 (UniProtKB | ChEBI)
Binding site36Zn2+ 1 (UniProtKB | ChEBI)
Binding site48Zn2+ 2 (UniProtKB | ChEBI)
Binding site51Zn2+ 2 (UniProtKB | ChEBI)
Binding site57Zn2+ 1 (UniProtKB | ChEBI)
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site74Zn2+ 2 (UniProtKB | ChEBI)
Binding site77Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionhistone reader activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of transcription elongation by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PHD finger-containing protein 4

Gene names

    • Name
      PHD4
    • ORF names
      MAF19.11
    • Ordered locus names
      At5g61110

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FNQ4
  • Secondary accessions
    • A0MFQ9

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Disruption phenotype

No obvious developmental defects (PubMed:33433058).
Plants missing all PHD finger-containing proteins (e.g. PHD1, PAIPP2/PHD2, AIPP2/PHD3, PHD4, PHD5 and PHD6) exhibit an increased expression of flowering genes leading to an early flowering phenotype under long-day conditions as well as growth retardation (PubMed:33433058).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004585481-161PHD finger-containing protein 4

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts directly with AIPP3/BDT1.

Family & Domains

Features

Showing features for zinc finger, region.

TypeIDPosition(s)Description
Zinc finger30-80PHD-type
Region114-161Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    17,249
  • Last updated
    2001-03-01 v1
  • Checksum
    4C95E11F67BD2052
MADESGYDAGSDAGSDASLPSSEISFVEVKKPCEVCGSNANDHAIMTCFLCRDTREHIYCARVHLRSVPRMWICEECRMNPVVVNNVAPVDQEAAASSSRITYQVADSEVVNQTMTSSDSGNQISATHQQPPQAHASPVAVPMDTSSSDNQQPPSDSESAI

Sequence caution

The sequence ABK28770.1 differs from that shown. Reason: Erroneous termination Extended C-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB006696
EMBL· GenBank· DDBJ
BAB10373.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97422.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ447099
EMBL· GenBank· DDBJ
ABE66267.1
EMBL· GenBank· DDBJ
mRNA
DQ653386
EMBL· GenBank· DDBJ
ABK28770.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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