Q9FNQ4 · PHD4_ARATH
- ProteinPHD finger-containing protein 4
- GenePHD4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids161 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Together with AIPP3/BDT1, cooperates to form a BAH-PHD bivalent histone reader complex able to read histone H3 lysine 27 trimethylation (H3K27me3) histone marks in order to regulate transcription, especially to prevent early flowering; promotes AIPP3/BDT1 binding to H3K27me3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 33 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 36 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 48 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 51 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 57 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 60 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 74 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 77 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | histone reader activity | |
Molecular Function | metal ion binding | |
Biological Process | negative regulation of transcription elongation by RNA polymerase II |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePHD finger-containing protein 4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FNQ4
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
No obvious developmental defects (PubMed:33433058).
Plants missing all PHD finger-containing proteins (e.g. PHD1, PAIPP2/PHD2, AIPP2/PHD3, PHD4, PHD5 and PHD6) exhibit an increased expression of flowering genes leading to an early flowering phenotype under long-day conditions as well as growth retardation (PubMed:33433058).
Plants missing all PHD finger-containing proteins (e.g. PHD1, PAIPP2/PHD2, AIPP2/PHD3, PHD4, PHD5 and PHD6) exhibit an increased expression of flowering genes leading to an early flowering phenotype under long-day conditions as well as growth retardation (PubMed:33433058).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000458548 | 1-161 | PHD finger-containing protein 4 | |||
Sequence: MADESGYDAGSDAGSDASLPSSEISFVEVKKPCEVCGSNANDHAIMTCFLCRDTREHIYCARVHLRSVPRMWICEECRMNPVVVNNVAPVDQEAAASSSRITYQVADSEVVNQTMTSSDSGNQISATHQQPPQAHASPVAVPMDTSSSDNQQPPSDSESAI |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts directly with AIPP3/BDT1.
Structure
Family & Domains
Features
Showing features for zinc finger, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 30-80 | PHD-type | ||||
Sequence: KKPCEVCGSNANDHAIMTCFLCRDTREHIYCARVHLRSVPRMWICEECRMN | ||||||
Region | 114-161 | Disordered | ||||
Sequence: TMTSSDSGNQISATHQQPPQAHASPVAVPMDTSSSDNQQPPSDSESAI |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)17,249
- Last updated2001-03-01 v1
- Checksum4C95E11F67BD2052
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB006696 EMBL· GenBank· DDBJ | BAB10373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ447099 EMBL· GenBank· DDBJ | ABE66267.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ653386 EMBL· GenBank· DDBJ | ABK28770.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |