Q9FNK4 · OAT_ARATH

Function

function

Mediates degradation of arginine for nitrogen recycling. Plays a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
91 mML-ornithine
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
28 μmol/h/mgtoward L-glutamate 5-semialdehyde
The activity was enhanced in young plants under salt-stress conditions.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site142-143pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site177pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site180L-ornithine (UniProtKB | ChEBI)
Binding site265-268pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site323L-ornithine (UniProtKB | ChEBI)
Binding site324pyridoxal 5'-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Cellular Componentplastid
Molecular Functionornithine aminotransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionzinc ion binding
Biological Processarginine catabolic process to glutamate
Biological Processdefense response to bacterium
Biological Processhyperosmotic salinity response
Biological Processmitochondrion localization
Biological Processornithine catabolic process
Biological Processplant-type hypersensitive response
Biological Processproline biosynthetic process
Biological Processresponse to salt stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ornithine aminotransferase, mitochondrial
  • EC number
  • Alternative names
    • Ornithine delta-aminotransferase
    • Ornithine--oxo-acid aminotransferase

Gene names

    • Name
      DELTA-OAT
    • ORF names
      MCL19.24
    • Ordered locus names
      At5g46180

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FNK4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Unable to use arginine or ornithine as nitrogen source. Displays sensitivity against type II non-host pathogen infection.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-16Mitochondrion
ChainPRO_000042129817-475Ornithine aminotransferase, mitochondrial
Modified residue294N6-(pyridoxal phosphate)lysine

Proteomic databases

PTM databases

Expression

Induction

By salt stress in young plants. Up-regulated during low water potential. Induced upon non-host pathogen infection.

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region23-43Disordered
Compositional bias24-43Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    475
  • Mass (Da)
    52,178
  • Last updated
    2001-03-01 v1
  • Checksum
    A886C999AB0B68CC
MAATTRRLLYYVSKRFSTAGVRRSYGGLPQSNSKSPPSSSQRLMELESEFSAHNYHPVPVVFSRANGSTIWDPEGKRYIDFLAAYSAVNQGHCHPKIMKALQEQVEKLTLSSRAFYNDKFPVFAERLTNMFGYDMVLPMNTGAEGVETALKLARKWGHEKKNIPKDEAIIVSCCGCFHGRTLAIVSMSCDNDATRGFGPLLPGNLKVDFGDADSLEKIFKEKGDRIAGFLFEPIQGEAGVIIPPDGYLKAVRELCTKYNVLMIADEVQSGLARSGKMLACDWEEIRPDMVILGKALGGGVIPVSAVLADKDVMLHIKPGQHGSTFGGNPLASAVAMASLDVIVEEKLVERSASLGEELRIQLNEIKKQFPKYIKEVRGRGLFNAIEFNSESLSPVSAYDICLSLKERGVLAKPTHNTIVRLTPPLSISSDELRDGSEALHDVLELDLPNLLKINSGKTPVSHITECDRCGRNLYA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-43Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB006698
EMBL· GenBank· DDBJ
BAB08263.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED95350.1
EMBL· GenBank· DDBJ
Genomic DNA
BT023421
EMBL· GenBank· DDBJ
AAY56412.1
EMBL· GenBank· DDBJ
mRNA
BT029160
EMBL· GenBank· DDBJ
ABJ17095.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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