Q9FN03 · UVR8_ARATH

Function

function

UV-B specific signaling component that acts as a UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplastid
Molecular Functionchromatin binding
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functionidentical protein binding
Molecular Functionphotoreceptor activity
Molecular Functionprotein homodimerization activity
Biological Processentrainment of circadian clock
Biological Processresponse to UV
Biological Processresponse to UV-B

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ultraviolet-B receptor UVR8
  • Alternative names
    • Protein UV-B RESISTANCE 8
    • RCC1 domain-containing protein UVR8

Gene names

    • Name
      UVR8
    • ORF names
      MGI19.7
    • Ordered locus names
      At5g63860

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Landsberg erecta
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FN03
  • Secondary accessions
    • Q9XHD7

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Cytoplasm, cytosol
Note: UV-B promotes rapid accumulation of UVR8 in the nucleus.

Keywords

Phenotypes & Variants

Disruption phenotype

Hypersensitivity to ultraviolet-B (UV-B) illumination (PubMed:12226503, PubMed:28735869).
Abrogated induction of DHU1 in response to UV-B (PubMed:28735869).
Disruption in a plant lacking DHU1 alleviates its hypersensitivity to UV-B (PubMed:28735869).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis39Loss of function, homodimerization and interaction with COP1.
Mutagenesis39No effect on function, homodimerization and interaction with COP1.
Mutagenesis39No effect on function, homodimerization and interaction with COP1.
Mutagenesis92No effect on function, homodimerization and interaction with COP1.
Mutagenesis94No effect on function, homodimerization and interaction with COP1.
Mutagenesis144Cannot interact with COP1.
Mutagenesis144No effect on the interaction with COP1.
Mutagenesis144No effect on the interaction with COP1.
Mutagenesis145In uvr8-15; loss of function and interaction with COP1.
Mutagenesis196No effect on function, homodimerization and interaction with COP1.
Mutagenesis196-200In uvr8-1; loss of function.
Mutagenesis198No effect on function, homodimerization and interaction with COP1.
Mutagenesis202In uvr8-9; loss of function and interaction with COP1.
Mutagenesis233Reduces response to UV-B.
Mutagenesis250No effect on function, homodimerization and interaction with COP1.
Mutagenesis283In uvr8-5; loss of response to UV-B.
Mutagenesis285Loss of function. Constitutive monomer.
Mutagenesis285Loss of function. Constitutive homodimer and no interaction with COP1.
Mutagenesis300No effect on function, homodimerization and interaction with COP1.
Mutagenesis302No effect on function, homodimerization and interaction with COP1.
Mutagenesis337Reduces response to UV-B.
Mutagenesis352Cannot interact with COP1.
Mutagenesis352No effect on the interaction with COP1.
Mutagenesis352No effect on the interaction with COP1.
Mutagenesis400No effect on function, homodimerization and interaction with COP1.

Variants

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The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00004217222-440Ultraviolet-B receptor UVR8

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer in the absence of UV-B, but absorption of UV-B induces monomerization of UVR8 and interaction with COP1. Interacts with RUP1, RUP2 and histone H2B.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q9FN03COP1 P432544EBI-2407499, EBI-301649
BINARY Q9FN03RUP2 Q9FFA73EBI-2407499, EBI-15889073
BINARY Q9FN03UVR8 Q9FN033EBI-2407499, EBI-2407499

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat, region.

Type
IDPosition(s)Description
Repeat2-31RCC1 1
Repeat32-84RCC1 2
Repeat86-137RCC1 3
Repeat139-189RCC1 4
Repeat190-241RCC1 5
Repeat243-293RCC1 6
Repeat294-345RCC1 7
Repeat347-399RCC1 8
Region397-423Required for interaction with COP1
Region413-440Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    47,118
  • Last updated
    2001-03-01 v1
  • Checksum
    D2EA103CCFC92E98
MAEDMAADEVTAPPRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSVDGASGQHIESSNIDPSSGKSWVSPAERYAVVPDETGLTDGSSKGNGGDISVPQTDVKRVRI

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict173in Ref. 1; AAD43920

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF130441
EMBL· GenBank· DDBJ
AAD43920.1
EMBL· GenBank· DDBJ
mRNA
AB007646
EMBL· GenBank· DDBJ
BAB11034.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97805.1
EMBL· GenBank· DDBJ
Genomic DNA
AY125497
EMBL· GenBank· DDBJ
AAM78089.1
EMBL· GenBank· DDBJ
mRNA
BT000600
EMBL· GenBank· DDBJ
AAN18169.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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