Q9FN03 · UVR8_ARATH
- ProteinUltraviolet-B receptor UVR8
- GeneUVR8
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids440 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
UV-B specific signaling component that acts as a UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plastid | |
Molecular Function | chromatin binding | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | identical protein binding | |
Molecular Function | photoreceptor activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | entrainment of circadian clock | |
Biological Process | response to UV | |
Biological Process | response to UV-B |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameUltraviolet-B receptor UVR8
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FN03
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: UV-B promotes rapid accumulation of UVR8 in the nucleus.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Hypersensitivity to ultraviolet-B (UV-B) illumination (PubMed:12226503, PubMed:28735869).
Abrogated induction of DHU1 in response to UV-B (PubMed:28735869).
Disruption in a plant lacking DHU1 alleviates its hypersensitivity to UV-B (PubMed:28735869).
Abrogated induction of DHU1 in response to UV-B (PubMed:28735869).
Disruption in a plant lacking DHU1 alleviates its hypersensitivity to UV-B (PubMed:28735869).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 39 | Loss of function, homodimerization and interaction with COP1. | |||
Mutagenesis | 39 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 39 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 92 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 94 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 144 | Cannot interact with COP1. | |||
Mutagenesis | 144 | No effect on the interaction with COP1. | |||
Mutagenesis | 144 | No effect on the interaction with COP1. | |||
Mutagenesis | 145 | In uvr8-15; loss of function and interaction with COP1. | |||
Mutagenesis | 196 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 196-200 | In uvr8-1; loss of function. | |||
Mutagenesis | 198 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 202 | In uvr8-9; loss of function and interaction with COP1. | |||
Mutagenesis | 233 | Reduces response to UV-B. | |||
Mutagenesis | 250 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 283 | In uvr8-5; loss of response to UV-B. | |||
Mutagenesis | 285 | Loss of function. Constitutive monomer. | |||
Mutagenesis | 285 | Loss of function. Constitutive homodimer and no interaction with COP1. | |||
Mutagenesis | 300 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 302 | No effect on function, homodimerization and interaction with COP1. | |||
Mutagenesis | 337 | Reduces response to UV-B. | |||
Mutagenesis | 352 | Cannot interact with COP1. | |||
Mutagenesis | 352 | No effect on the interaction with COP1. | |||
Mutagenesis | 352 | No effect on the interaction with COP1. | |||
Mutagenesis | 400 | No effect on function, homodimerization and interaction with COP1. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylalanine | |||
Chain | PRO_0000421722 | 2-440 | Ultraviolet-B receptor UVR8 | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer in the absence of UV-B, but absorption of UV-B induces monomerization of UVR8 and interaction with COP1. Interacts with RUP1, RUP2 and histone H2B.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9FN03 | COP1 P43254 | 4 | EBI-2407499, EBI-301649 | |
BINARY | Q9FN03 | RUP2 Q9FFA7 | 3 | EBI-2407499, EBI-15889073 | |
BINARY | Q9FN03 | UVR8 Q9FN03 | 3 | EBI-2407499, EBI-2407499 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 2-31 | RCC1 1 | |||
Repeat | 32-84 | RCC1 2 | |||
Repeat | 86-137 | RCC1 3 | |||
Repeat | 139-189 | RCC1 4 | |||
Repeat | 190-241 | RCC1 5 | |||
Repeat | 243-293 | RCC1 6 | |||
Repeat | 294-345 | RCC1 7 | |||
Repeat | 347-399 | RCC1 8 | |||
Region | 397-423 | Required for interaction with COP1 | |||
Region | 413-440 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length440
- Mass (Da)47,118
- Last updated2001-03-01 v1
- ChecksumD2EA103CCFC92E98
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 173 | in Ref. 1; AAD43920 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF130441 EMBL· GenBank· DDBJ | AAD43920.1 EMBL· GenBank· DDBJ | mRNA | ||
AB007646 EMBL· GenBank· DDBJ | BAB11034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY125497 EMBL· GenBank· DDBJ | AAM78089.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000600 EMBL· GenBank· DDBJ | AAN18169.1 EMBL· GenBank· DDBJ | mRNA |