Q9FMM3 · EXA1_ARATH
- ProteinProtein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1
- GeneEXA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1714 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Translational repressor involved in the negative regulation of immune receptor accumulation via the inhibition of nucleotide-binding leucine-rich repeat (NLR) receptor mediated defense (PubMed:28362261).
Represses NLR protein accumulation (e.g. SNC1, RPS4, RPM1 and RPS2) (PubMed:28362261).
Together with SMG7, helps to restrict effector-triggered immunity (ETI) cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner (PubMed:29073135).
Required for pathogen-associated molecular pattern (PAMP)-induced suppression of necrotrophic fungal (e.g. F.moniliforme) pathogen-derived mycotoxin-triggered (e.g. fumonisin B1) cell death (PubMed:29073135).
Represses NLR protein accumulation (e.g. SNC1, RPS4, RPM1 and RPS2) (PubMed:28362261).
Together with SMG7, helps to restrict effector-triggered immunity (ETI) cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner (PubMed:29073135).
Required for pathogen-associated molecular pattern (PAMP)-induced suppression of necrotrophic fungal (e.g. F.moniliforme) pathogen-derived mycotoxin-triggered (e.g. fumonisin B1) cell death (PubMed:29073135).
(Microbial infection) Required for early steps of plantago asiatica mosaic virus (PlAMV, genus Potexvirus) infection (PubMed:27402258).
Facilitates pathogenic growth of avirulent hemi-biotrophic bacteria P.syringae pv. tomato (Pst) DC3000 (e.g. AvrRps4 and AvrRpm1) and of the compatible oomycete H.arabidopsidis Noco2 (PubMed:28362261, PubMed:29073135).
Facilitates pathogenic growth of avirulent hemi-biotrophic bacteria P.syringae pv. tomato (Pst) DC3000 (e.g. AvrRps4 and AvrRpm1) and of the compatible oomycete H.arabidopsidis Noco2 (PubMed:28362261, PubMed:29073135).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | P-body | |
Cellular Component | plastid | |
Molecular Function | mRNA binding | |
Molecular Function | translation repressor activity | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to fungus | |
Biological Process | defense response to oomycetes | |
Biological Process | defense response to virus | |
Biological Process | programmed cell death | |
Biological Process | regulation of defense response | |
Biological Process | response to molecule of bacterial origin |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FMM3
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced size with a curly leaf phenotype associated with an abnormal constitutive PR1 expression (PubMed:28362261, PubMed:29073135).
No spontaneous lesions, but enhanced cell death independent of salicylic acid (SA) biosynthesis or reactive oxygen species (ROS) production during pathogen infection (e.g. P.syringae and F.moniliforme) (PubMed:29073135).
Heightened nucleotide-binding leucine-rich repeat protein (NLR, e.g. SNC1, RPS4, RPM1 and RPS2) accumulation and enhanced resistance against virulent pathogens (PubMed:28362261).
Enhanced snc1-mediated autoimmunity including stunted growth, increased expression of pathogenesis related (PR, e.g. PR1 and PR2) genes and enhanced disease resistance against the virulent oomycete pathogen H.arabidopsidis Noco2, and reduced hemi-biotrophic bacterial growth of P.syringae pv. tomato (Pst) DC3000 expressing avirulent effectors AvrRps4 and AvrRpm1 (PubMed:28362261, PubMed:29073135).
Abnormal resistance to plantago asiatica mosaic virus (PlAMV, genus Potexvirus) with the absence of infection foci prior to cell-to-cell movement (PubMed:27402258).
Increased oxidative bursts, mitogen-activated protein kinase activation and callose deposition in response to the pathogen-associated molecular pattern (PAMP) flg22 (PubMed:29073135).
No spontaneous lesions, but enhanced cell death independent of salicylic acid (SA) biosynthesis or reactive oxygen species (ROS) production during pathogen infection (e.g. P.syringae and F.moniliforme) (PubMed:29073135).
Heightened nucleotide-binding leucine-rich repeat protein (NLR, e.g. SNC1, RPS4, RPM1 and RPS2) accumulation and enhanced resistance against virulent pathogens (PubMed:28362261).
Enhanced snc1-mediated autoimmunity including stunted growth, increased expression of pathogenesis related (PR, e.g. PR1 and PR2) genes and enhanced disease resistance against the virulent oomycete pathogen H.arabidopsidis Noco2, and reduced hemi-biotrophic bacterial growth of P.syringae pv. tomato (Pst) DC3000 expressing avirulent effectors AvrRps4 and AvrRpm1 (PubMed:28362261, PubMed:29073135).
Abnormal resistance to plantago asiatica mosaic virus (PlAMV, genus Potexvirus) with the absence of infection foci prior to cell-to-cell movement (PubMed:27402258).
Increased oxidative bursts, mitogen-activated protein kinase activation and callose deposition in response to the pathogen-associated molecular pattern (PAMP) flg22 (PubMed:29073135).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 575 | Enhanced cell death phenotype triggered by P.syringae pv. tomato (Pst) DC3000. Abolished interaction with SMG7. | ||||
Sequence: Y → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 204 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000447893 | 1-1714 | Protein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1 | |||
Sequence: MANSSAGSAADHRNKHLSVNPPHQIFKDIQGSDNAIPLSPQWLLSKPGENKTGMGTGDPNQYGNHSDVVRTTGNGEETLDNLKKKDVFRPSLLDAESGRRDRWRDEERDTLSSVRNDRWRNGDKDSGDNKKVDRWDNVAPKFGEQRRGPNDRWTDSGNKDAAPEQRRESKWNSRWGPDDKEAEIPRNKWDEPGKDGEIIREKGPSLPTSDGDHYRPWRPSQGRGRGEALHNQSTPNKQVTSFSHSRGRGENTAIFSAGRGRMSPGGSIFTSAPNQSHPPGSASDKGESGPGEPPHLRYSRMKLLDVYRMADTECYEKFPDGFIEVPSLTSEEPTDPLALCAPSSDEVNVLDAIEKGKIVSSGAPQTSKDGPTGRNPVEFSQPRRIRPAGSREDMTFGAEESKDESGETRNYPDDKFRPEASHEGYAPFRRGNEAPVRELKEPSMQGNAHVQSASPWRQSSGGERSNRNSHDWNDPSADSRLKSSDSVWSHPKDSINHLGGNNMMLPQSKGESRWQISEDPSLRRQPSLVFDREQEVRKLLPSSPEELSLYYKDPQGLIQGPFSGSDIIGWFEAGYFGIDLLVRLASAPNDSPFSLLGDVMPHLRAKSGPPPGFTGAKQNEFVDAAGTSAFPGVGKVHSGMGETDMLQNDMRYKHVAGTVAENRFIESLMSGGLTNSAQGVQGYGVNSSGGLSLPVTDGGADMYLLAKKLELERQRSIPSPYSYWPGRESANLMPGSENVSENAQQPTRSPSSDLLSILQGVTDRSSPAVSGPLPAWSQPIQKESDLHHAKTFQTQIPFGVQQQRLPEQNLPLSGLLGQPMENNPGGMLSPDMMLAAGLSQEHQSLNLLQQQQLLLQLNAQTPLSAQHQRLLVEKMLLLKHQHKQEEQQQLLRQQQQLYSQVFADQQRSQQRFGDPSYGQLQASLDALRLQPSKDMSQVNQQVQVPVSHEERGINLADLLPVTHATNQTVASFETPSLHLQNQLFGNVDPRMVLPDQIDDTHKKESKSEYERTVSADYVNSLYSEKPVLSPGYHATHNVEEPVSYPNNESSTATMTAPEIVESKLLEEQSKDMYAGKGEVSIELSGETPATEVKNNDVSVARKTSEKKSRKQRAKQAADLAKSTSRAPLQETKKPQPGSADDSEIKGKTKKSADTLIDNDTHLIKSSTATASNTSQMSSEVDSVRGEESSLQNTRTQPGRAWKPAPGFKPKSLLEIQMEEQRVAQAEALAPKISSTVNSVGSAAPWAGIVTNSDSNILRETHGESAITQTGVVKPESVPTLKAKKSHLHDLLADDVFAKSSDKEREVMEIISNNDAFMQVTTTNAESFDDDNFIDARETKKSRKKSARAKTSGAKIAAHVPAVDTSLQTNSVEKGKSSRILQQQEKEVLPAIPSGPSLGDFVLWKGESVNNPPPAAAWSSGPKKSTKPSSLRDIVKEQEKMTTSSHPPPSPVPTTQKAIPPQAHQGGASWSRSASSPSQAVSQSSSQSKSKGDDDLFWGPVEQSTQDTKQGDFPHLTSQNSWGTKNTPGKVNAGTSLNRQKSVSMGSADRVLSSPVVTQASHKGKKEAVTKLTEANGFRDWCKSECLRLLGSEDTSVLEFCLKLSRSEAETLLIENLGSRDPDHKFIDKFLNYKDLLPSEVVEIAFQSKGSGVGTRNNTGEDYYYNTTAANDGFSKVGGKKKAKKGKKVSLSASVLGFNVVSNRIMMGEIQTIED | ||||||
Modified residue | 39 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Quickly phosphorylated at Ser-39 after treatment of seedlings with the pathogen-associated molecular pattern (PAMP) flg22.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in all tissues, mostly in flowers, leaves and stems, and, to a lower extent, in roots (at protein level).
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-296 | Disordered | ||||
Sequence: MANSSAGSAADHRNKHLSVNPPHQIFKDIQGSDNAIPLSPQWLLSKPGENKTGMGTGDPNQYGNHSDVVRTTGNGEETLDNLKKKDVFRPSLLDAESGRRDRWRDEERDTLSSVRNDRWRNGDKDSGDNKKVDRWDNVAPKFGEQRRGPNDRWTDSGNKDAAPEQRRESKWNSRWGPDDKEAEIPRNKWDEPGKDGEIIREKGPSLPTSDGDHYRPWRPSQGRGRGEALHNQSTPNKQVTSFSHSRGRGENTAIFSAGRGRMSPGGSIFTSAPNQSHPPGSASDKGESGPGEPPHL | ||||||
Compositional bias | 54-76 | Polar residues | ||||
Sequence: MGTGDPNQYGNHSDVVRTTGNGE | ||||||
Compositional bias | 77-201 | Basic and acidic residues | ||||
Sequence: ETLDNLKKKDVFRPSLLDAESGRRDRWRDEERDTLSSVRNDRWRNGDKDSGDNKKVDRWDNVAPKFGEQRRGPNDRWTDSGNKDAAPEQRRESKWNSRWGPDDKEAEIPRNKWDEPGKDGEIIRE | ||||||
Compositional bias | 226-250 | Polar residues | ||||
Sequence: GEALHNQSTPNKQVTSFSHSRGRGE | ||||||
Compositional bias | 267-282 | Polar residues | ||||
Sequence: SIFTSAPNQSHPPGSA | ||||||
Region | 358-511 | Disordered | ||||
Sequence: IVSSGAPQTSKDGPTGRNPVEFSQPRRIRPAGSREDMTFGAEESKDESGETRNYPDDKFRPEASHEGYAPFRRGNEAPVRELKEPSMQGNAHVQSASPWRQSSGGERSNRNSHDWNDPSADSRLKSSDSVWSHPKDSINHLGGNNMMLPQSKGE | ||||||
Compositional bias | 360-374 | Polar residues | ||||
Sequence: SSGAPQTSKDGPTGR | ||||||
Compositional bias | 385-426 | Basic and acidic residues | ||||
Sequence: IRPAGSREDMTFGAEESKDESGETRNYPDDKFRPEASHEGYA | ||||||
Compositional bias | 445-466 | Polar residues | ||||
Sequence: QGNAHVQSASPWRQSSGGERSN | ||||||
Domain | 546-597 | GYF | ||||
Sequence: ELSLYYKDPQGLIQGPFSGSDIIGWFEAGYFGIDLLVRLASAPNDSPFSLLG | ||||||
Region | 728-753 | Disordered | ||||
Sequence: ESANLMPGSENVSENAQQPTRSPSSD | ||||||
Compositional bias | 733-753 | Polar residues | ||||
Sequence: MPGSENVSENAQQPTRSPSSD | ||||||
Region | 1092-1205 | Disordered | ||||
Sequence: VKNNDVSVARKTSEKKSRKQRAKQAADLAKSTSRAPLQETKKPQPGSADDSEIKGKTKKSADTLIDNDTHLIKSSTATASNTSQMSSEVDSVRGEESSLQNTRTQPGRAWKPAP | ||||||
Compositional bias | 1098-1116 | Basic and acidic residues | ||||
Sequence: SVARKTSEKKSRKQRAKQA | ||||||
Compositional bias | 1136-1157 | Basic and acidic residues | ||||
Sequence: PGSADDSEIKGKTKKSADTLID | ||||||
Compositional bias | 1158-1198 | Polar residues | ||||
Sequence: NDTHLIKSSTATASNTSQMSSEVDSVRGEESSLQNTRTQPG | ||||||
Region | 1437-1566 | Disordered | ||||
Sequence: QEKMTTSSHPPPSPVPTTQKAIPPQAHQGGASWSRSASSPSQAVSQSSSQSKSKGDDDLFWGPVEQSTQDTKQGDFPHLTSQNSWGTKNTPGKVNAGTSLNRQKSVSMGSADRVLSSPVVTQASHKGKKE | ||||||
Compositional bias | 1456-1491 | Polar residues | ||||
Sequence: KAIPPQAHQGGASWSRSASSPSQAVSQSSSQSKSKG | ||||||
Compositional bias | 1500-1559 | Polar residues | ||||
Sequence: VEQSTQDTKQGDFPHLTSQNSWGTKNTPGKVNAGTSLNRQKSVSMGSADRVLSSPVVTQA |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,714
- Mass (Da)187,619
- Last updated2001-03-01 v1
- Checksum38E850BC82164840
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 54-76 | Polar residues | ||||
Sequence: MGTGDPNQYGNHSDVVRTTGNGE | ||||||
Compositional bias | 77-201 | Basic and acidic residues | ||||
Sequence: ETLDNLKKKDVFRPSLLDAESGRRDRWRDEERDTLSSVRNDRWRNGDKDSGDNKKVDRWDNVAPKFGEQRRGPNDRWTDSGNKDAAPEQRRESKWNSRWGPDDKEAEIPRNKWDEPGKDGEIIRE | ||||||
Compositional bias | 226-250 | Polar residues | ||||
Sequence: GEALHNQSTPNKQVTSFSHSRGRGE | ||||||
Compositional bias | 267-282 | Polar residues | ||||
Sequence: SIFTSAPNQSHPPGSA | ||||||
Compositional bias | 360-374 | Polar residues | ||||
Sequence: SSGAPQTSKDGPTGR | ||||||
Compositional bias | 385-426 | Basic and acidic residues | ||||
Sequence: IRPAGSREDMTFGAEESKDESGETRNYPDDKFRPEASHEGYA | ||||||
Compositional bias | 445-466 | Polar residues | ||||
Sequence: QGNAHVQSASPWRQSSGGERSN | ||||||
Compositional bias | 733-753 | Polar residues | ||||
Sequence: MPGSENVSENAQQPTRSPSSD | ||||||
Compositional bias | 1098-1116 | Basic and acidic residues | ||||
Sequence: SVARKTSEKKSRKQRAKQA | ||||||
Compositional bias | 1136-1157 | Basic and acidic residues | ||||
Sequence: PGSADDSEIKGKTKKSADTLID | ||||||
Compositional bias | 1158-1198 | Polar residues | ||||
Sequence: NDTHLIKSSTATASNTSQMSSEVDSVRGEESSLQNTRTQPG | ||||||
Compositional bias | 1456-1491 | Polar residues | ||||
Sequence: KAIPPQAHQGGASWSRSASSPSQAVSQSSSQSKSKG | ||||||
Compositional bias | 1500-1559 | Polar residues | ||||
Sequence: VEQSTQDTKQGDFPHLTSQNSWGTKNTPGKVNAGTSLNRQKSVSMGSADRVLSSPVVTQA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LC130495 EMBL· GenBank· DDBJ | BAX09292.1 EMBL· GenBank· DDBJ | mRNA | ||
AB008264 EMBL· GenBank· DDBJ | BAB09197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED94891.1 EMBL· GenBank· DDBJ | Genomic DNA |