Q9FJX3 · VDAC2_ARATH
- ProteinMitochondrial outer membrane protein porin 2
- GeneVDAC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids276 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in ABA-mediated early seedling development and disease resistance
Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in ABA-mediated early seedling development and disease resistance
Miscellaneous
Plants silencing VDAC2 show an ABA-insensitive phenotype during early seedling development under ABA treatment.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Cellular Component | pore complex | |
Molecular Function | porin activity | |
Molecular Function | voltage-gated monoatomic anion channel activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMitochondrial outer membrane protein porin 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FJX3
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Also localized in other unidentified cellular compartments.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Dwarf plants with lesion mimic phenotype and increased expression of the pathogenesis-related genes PR1, PR2 and PR5. Delayed flowering, impaired development of anthers and short siliques with sterile seeds.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 223 | Alteration of subcellular localization. | ||||
Sequence: H → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000414081 | 1-276 | Mitochondrial outer membrane protein porin 2 | |||
Sequence: MSKGPGLFTDIGKKAKDLLTRDYNSDQKFSISTYSASGVALTSTALKKGGVHAADVATQYKYKNALFDVKIDTDSSVLTTVTLTEILPSTKAIASFKVPDYNSAKLEVQYFHDHATVTAAAALKQNPLIDITATLGSPVISFGAEAGYDTTSKTFTKYNAGISVTKPDACLSIILGDKGDSLKASYLHHFDEFKRTAAVGEVYRKFSTNENTITVGGLYAIDHSTAVKAKLNNHGTLGALLQHEVLPRSLVTVSSEIDTKALEKHPRFGLSLALKP | ||||||
Modified residue | 76 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 236 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in root tips, steles, leaves, sepals, petals, stamen and pistils.
Induction
By the bacterial pathogen P.syringae pv. tomato. Down-regulated by abscisic acid (ABA).
Gene expression databases
Structure
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q9FJX3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length276
- Mass (Da)29,595
- Last updated2001-03-01 v1
- ChecksumC0B0B35525D7D888
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4K3R8 | F4K3R8_ARATH | VDAC2 | 303 | ||
A0A2H1ZE94 | A0A2H1ZE94_ARATH | VDAC2 | 305 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB013390 EMBL· GenBank· DDBJ | BAB08458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | ANM69845.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT025802 EMBL· GenBank· DDBJ | ABF83692.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085100 EMBL· GenBank· DDBJ | AAM61654.1 EMBL· GenBank· DDBJ | mRNA |