Q9FIZ7 · OPLA_ARATH
- Protein5-oxoprolinase 1
- GeneOXP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1266 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Acts in the glutathione degradation pathway.
Catalytic activity
- 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + phosphate + H+
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | plasmodesma | |
Cellular Component | plastid | |
Molecular Function | 5-oxoprolinase (ATP-hydrolyzing) activity | |
Molecular Function | ATP binding | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-oxoprolinase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FIZ7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
No morphological phenotype, but high accumulation of 5-oxoproline and decreased concentration of glutamate.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 106 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000380674 | 1-1266 | 5-oxoprolinase 1 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, stems, leaves, flowers and siliques.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length1,266
- Mass (Da)137,531
- Last updated2001-03-01 v1
- MD5 Checksum1DC566F8DCF9D78FF923AAE7A29417B5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB016873 EMBL· GenBank· DDBJ | BAB10362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED94237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY102096 EMBL· GenBank· DDBJ | AAM26666.1 EMBL· GenBank· DDBJ | mRNA | ||
BT004510 EMBL· GenBank· DDBJ | AAO42756.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228904 EMBL· GenBank· DDBJ | BAF00793.1 EMBL· GenBank· DDBJ | mRNA |