Q9FI55 · CENPS_ARATH

Function

function

Involved in the promotion of spontaneous somatic homologous recombination (HR) events, which is opposite to the function of FANCM in ordered HR. Only FANCM is essential for replicative repair in the absence of the endonuclease MUS81 (PubMed:24635147).
Acts in the same pathway as FANCM to restrain class II meiotic crossing over (CO), and acts with FANCM during meiosis to repair interstrand cross-links (ICLs) (PubMed:24635147, PubMed:25038251).
This common pathway between MHF1 and FANCM is in parallel to the pathway that involves the RECQ4A helicase (PubMed:24635147).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentFANCM-MHF complex
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Biological Processhomologous chromosome pairing at meiosis
Biological Processinterstrand cross-link repair
Biological Processmitotic recombination
Biological Processreciprocal meiotic recombination

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein MHF1 homolog
  • Short names
    AtMHF1

Gene names

    • Name
      MHF1
    • ORF names
      K3K7.8
    • Ordered locus names
      At5g50930

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FI55

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but mutant plants exhibit a defect in somatic homologous recombination.

Variants

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The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004400381-242Protein MHF1 homolog

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region208-242Disordered
Compositional bias209-232Basic and acidic residues

Sequence similarities

Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    242
  • Mass (Da)
    27,292
  • Last updated
    2001-03-01 v1
  • Checksum
    2AC65E96AEBC83BD
MFNISYAKRNAKYLFKLLAWCMMIEEAGPNIGNKQKVVLQLSKMLIMYIILHINAAFWTWRGYLKRCVLHFVFPRIFLPLLSDSPTITQAKKPSYCFAMDVGGEDISDLQVDQIVEEYSMDDLIRDRFRLSAISIAEAEAKKNGMEIGGPVVACVADLAFKYAENVAKDLELFAHHAGRKVVNMDDVVLSAHRNDNLAASLRSLCNELKAKEPQSERKRKKGSAKKEDKASSSNAVRITTDL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias209-232Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB017063
EMBL· GenBank· DDBJ
BAB08739.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED96012.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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