Q9FHP6 · CAR1_ARATH
- ProteinProtein C2-DOMAIN ABA-RELATED 1
- GeneCAR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids168 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity).
Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:25465408).
Binds liposomes in the absence of exogenous Ca2+, but this activity is enhanced in the presence of Ca2+ and generates membrane curvature (By similarity).
Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:25465408).
Binds liposomes in the absence of exogenous Ca2+, but this activity is enhanced in the presence of Ca2+ and generates membrane curvature (By similarity).
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 21 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 22 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 22 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 27 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 73 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 73 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 74 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 75 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 75 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 81 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | GTPase activator activity | |
Molecular Function | lipid binding | |
Molecular Function | phospholipid binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | abscisic acid-activated signaling pathway | |
Biological Process | positive regulation of abscisic acid-activated signaling pathway | |
Biological Process | positive regulation of GTPase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein C2-DOMAIN ABA-RELATED 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FHP6
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
When associated with disruption in CAR4, CAR5 and CAR9 genes, reduced sensitivity to abscisic acid (ABA) during seedling establishment and root growth regulation.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 22 | Impaired Ca2+-dependent phospholipids binding; when associated with A-27. | ||||
Sequence: D → A | ||||||
Mutagenesis | 27 | Impaired Ca2+-dependent phospholipids binding; when associated with A-22. | ||||
Sequence: D → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000433311 | 1-168 | Protein C2-DOMAIN ABA-RELATED 1 | |||
Sequence: MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKLTVYDYDLLSADDKMGEAEFHIGPFIEAIKFAHQLGPGLPNGTIIKKIEPSRKNCLSESSHIVLNQGKIVQNMFLRLQHVECGEVELQLEWIDVPGSRGI |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in roots.
Developmental stage
Predominantly expressed in the vascular bundle of the primary root and in the cortex of the root upper part. In lateral roots, detected in epidermis and root tips.
Gene expression databases
Interaction
Subunit
Dimers and oligomers (By similarity).
Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus. Interacts directly with PYR1, PYL1, PYL4, PYL6 and PYL8. Binds phospholipids in a Ca2+-dependent manner.
Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus. Interacts directly with PYR1, PYL1, PYL4, PYL6 and PYL8. Binds phospholipids in a Ca2+-dependent manner.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-104 | C2 | ||||
Sequence: MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKLTVYDYDLLSADDKMGEAEFHIGPFIEAIKFAHQLG |
Sequence similarities
Belongs to the plant CAR protein family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q9FHP6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length168
- Mass (Da)18,842
- Last updated2001-03-01 v1
- Checksum488EF142D8CA80D8
Q9FHP6-2
- Name2
- Differences from canonical
- 1-69: MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKL → MMQ
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4K8L6 | F4K8L6_ARATH | At5g37740 | 178 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057720 | 1-69 | in isoform 2 | |||
Sequence: MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKL → MMQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB018107 EMBL· GenBank· DDBJ | BAB08320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED94225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY074354 EMBL· GenBank· DDBJ | AAL67050.1 EMBL· GenBank· DDBJ | mRNA | ||
AY113975 EMBL· GenBank· DDBJ | AAM45023.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000677 EMBL· GenBank· DDBJ | AAN31823.1 EMBL· GenBank· DDBJ | mRNA | ||
AK318949 EMBL· GenBank· DDBJ | BAH57064.1 EMBL· GenBank· DDBJ | mRNA |