Q9FHP6 · CAR1_ARATH

Function

function

Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity).
Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:25465408).
Binds liposomes in the absence of exogenous Ca2+, but this activity is enhanced in the presence of Ca2+ and generates membrane curvature (By similarity).

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Features

Showing features for binding site.

116820406080100120140160
TypeIDPosition(s)Description
Binding site21Ca2+ 1 (UniProtKB | ChEBI)
Binding site22Ca2+ 1 (UniProtKB | ChEBI)
Binding site22Ca2+ 2 (UniProtKB | ChEBI)
Binding site27Ca2+ 2 (UniProtKB | ChEBI)
Binding site73Ca2+ 1 (UniProtKB | ChEBI)
Binding site73Ca2+ 2 (UniProtKB | ChEBI)
Binding site74Ca2+ 2 (UniProtKB | ChEBI)
Binding site75Ca2+ 1 (UniProtKB | ChEBI)
Binding site75Ca2+ 2 (UniProtKB | ChEBI)
Binding site81Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular FunctionGTPase activator activity
Molecular Functionlipid binding
Molecular Functionphospholipid binding
Molecular Functionprotein homodimerization activity
Biological Processabscisic acid-activated signaling pathway
Biological Processpositive regulation of abscisic acid-activated signaling pathway
Biological Processpositive regulation of GTPase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein C2-DOMAIN ABA-RELATED 1

Gene names

    • Name
      CAR1
    • ORF names
      K12B20.22
    • Ordered locus names
      At5g37740

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FHP6
  • Secondary accessions
    • C0Z2Y5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

When associated with disruption in CAR4, CAR5 and CAR9 genes, reduced sensitivity to abscisic acid (ABA) during seedling establishment and root growth regulation.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis22Impaired Ca2+-dependent phospholipids binding; when associated with A-27.
Mutagenesis27Impaired Ca2+-dependent phospholipids binding; when associated with A-22.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00004333111-168

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in roots.

Developmental stage

Predominantly expressed in the vascular bundle of the primary root and in the cortex of the root upper part. In lateral roots, detected in epidermis and root tips.

Gene expression databases

Interaction

Subunit

Dimers and oligomers (By similarity).
Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus. Interacts directly with PYR1, PYL1, PYL4, PYL6 and PYL8. Binds phospholipids in a Ca2+-dependent manner.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-104C2

Sequence similarities

Belongs to the plant CAR protein family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

Q9FHP6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    168
  • Mass (Da)
    18,842
  • Last updated
    2001-03-01 v1
  • Checksum
    488EF142D8CA80D8
MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKLTVYDYDLLSADDKMGEAEFHIGPFIEAIKFAHQLGPGLPNGTIIKKIEPSRKNCLSESSHIVLNQGKIVQNMFLRLQHVECGEVELQLEWIDVPGSRGI

Q9FHP6-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-69: MENLVGLLRIHVKRGVNLAIRDISSSDPYIVVHCGKQKLKTRVVKHSVNPEWNDDLTLSVTDPNLPIKL → MMQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4K8L6F4K8L6_ARATHAt5g37740178

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0577201-69in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB018107
EMBL· GenBank· DDBJ
BAB08320.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED94225.1
EMBL· GenBank· DDBJ
Genomic DNA
AY074354
EMBL· GenBank· DDBJ
AAL67050.1
EMBL· GenBank· DDBJ
mRNA
AY113975
EMBL· GenBank· DDBJ
AAM45023.1
EMBL· GenBank· DDBJ
mRNA
BT000677
EMBL· GenBank· DDBJ
AAN31823.1
EMBL· GenBank· DDBJ
mRNA
AK318949
EMBL· GenBank· DDBJ
BAH57064.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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