Q9FGN7 · SCC4_ARATH
- ProteinSister chromatid cohesion protein SCC4
- GeneSCC4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids726 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | cell division | |
Biological Process | chromosome segregation | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | mitotic sister chromatid cohesion |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSister chromatid cohesion protein SCC4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9FGN7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Defective embryo arrested at preglobular/early globular stage. Suspensor overproliferation phenotype preceded by ectopic auxin maxima distribution. Reduced efficacy of cohesin immobilization in nuclei.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440651 | 1-726 | Sister chromatid cohesion protein SCC4 | |||
Sequence: MEGAAVAEGLWGLADHHQKLGEIGKTIKCLEAICQSQISFLPLVEVKSRLRLAALLLRYSHNVNHAKSHLERSLLLLKSIPSSYDLKFQNYSLLSHCYHLLASFPPQRNLLVKALELASSVPQDISAYLWSCNFNSQLANTFIIQADFPSSLSALESGFLSASHICFPELQMFFTASMLHVHIMQWTDDYSVEKAVQRCDEIWQTISSDKTDRCPGLFFYNEMLHVFYRLRLCDYKNAQHHVDRLDQAMNAHSHKMQEIQQLLDELSSLNLSLSRYDLPSRERSALSARQSQLQDRVNALSPSSSTVNSLEPAYFGNIDRGWTEKLLLSPSPIDGEWLPKSAIDALVHLMVVISGRPKGLFKECSKRIESGLQIIQDELIKLGITDEVREADLRHTAIWMSRVFLMLQMQFLENRVALELTRSDYVEAEEALVDMKNWFTRFPTILQASECMIEMLRGQYSHSVGCYSEAAFHCIEATKLTESISMQASCQAFAAVSYLTIGDAESSSKALDLIGPLNGMTNSLSGVREEASILFAYGLLLMKQRDLQEARNRLAKGLQIAHNHMGNLQLVAQYLTLLGNLALSLHDTVQAREILRSSLTLAKKLYDIPTQLWVLSIFTALYQQLGEKGNEMENEEFRKKKWDELQSRLAEARGSIHHIELVAKARIELYQIDNNPQEQSLVASAQSMQGNLDIPESVGIEGPSPAPSSSRLVGLDTGKRWGKRRM |
Proteomic databases
Expression
Interaction
Subunit
Interacts with SCC2 to form the cohesin loading complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 7-40 | TPR 1 | ||||
Sequence: AEGLWGLADHHQKLGEIGKTIKCLEAICQSQISF | ||||||
Repeat | 88-121 | TPR 2 | ||||
Sequence: FQNYSLLSHCYHLLASFPPQRNLLVKALELASSV | ||||||
Repeat | 132-165 | TPR 3 | ||||
Sequence: CNFNSQLANTFIIQADFPSSLSALESGFLSASHI | ||||||
Repeat | 229-262 | TPR 4 | ||||
Sequence: RLRLCDYKNAQHHVDRLDQAMNAHSHKMQEIQQL | ||||||
Repeat | 443-477 | TPR 5 | ||||
Sequence: PTILQASECMIEMLRGQYSHSVGCYSEAAFHCIEA | ||||||
Repeat | 531-564 | TPR 6 | ||||
Sequence: ASILFAYGLLLMKQRDLQEARNRLAKGLQIAHNH | ||||||
Repeat | 572-605 | TPR 7 | ||||
Sequence: AQYLTLLGNLALSLHDTVQAREILRSSLTLAKKL | ||||||
Region | 697-726 | Disordered | ||||
Sequence: SVGIEGPSPAPSSSRLVGLDTGKRWGKRRM |
Sequence similarities
Belongs to the SCC4/mau-2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length726
- Mass (Da)81,880
- Last updated2001-03-01 v1
- Checksum74F3A6F3EC3ABBCD
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 437 | in Ref. 3; BAF00935 | ||||
Sequence: N → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB025621 EMBL· GenBank· DDBJ | BAB09745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED96068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK229053 EMBL· GenBank· DDBJ | BAF00935.1 EMBL· GenBank· DDBJ | mRNA |