Q9FE17 · SIR1_ARATH

Function

function

NAD-dependent protein deacetylase (By similarity).
Has deacetylase activity towards H3K9Ac (By similarity).
May have a function in the safeguard against genome instability and DNA damage to ensure plant cell growth (By similarity).
Involved in responses to ethylene leading to the transcriptional repression of some ethylene-responsive genes via the regulation of histone acetylation H3K9Ac (PubMed:29298835).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site52-71NAD+ (UniProtKB | ChEBI)
Binding site114-117NAD+ (UniProtKB | ChEBI)
Active site134Proton acceptor
Binding site142Zn2+ (UniProtKB | ChEBI)
Binding site145Zn2+ (UniProtKB | ChEBI)
Binding site167Zn2+ (UniProtKB | ChEBI)
Binding site172Zn2+ (UniProtKB | ChEBI)
Binding site209-211NAD+ (UniProtKB | ChEBI)
Binding site235-237NAD+ (UniProtKB | ChEBI)
Binding site253NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionchromatin DNA binding
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Biological Processethylene-activated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase SRT1
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog 1
    • SIR2-like protein 1

Gene names

    • Name
      SRT1
    • ORF names
      MDF20.20
    • Ordered locus names
      At5g55760

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9FE17
  • Secondary accessions
    • Q7Y032

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced ethylene sensitivity in the double mutant srt1 srt2.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 29 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004173651-473NAD-dependent protein deacetylase SRT1

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binds to the promoter region of genes influenced by ethylene (By similarity).
Interacts with ENAP1; this interaction is enhanced in the presence of ethylene (PubMed:29298835).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain27-267Deacetylase sirtuin-type
Region447-473Disordered

Sequence similarities

Belongs to the sirtuin family. Class IV subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    52,642
  • Last updated
    2001-03-01 v1
  • Checksum
    C265296654DE3E9D
MSLGYAEKLSFIEDVGQVGMAEFFDPSHLLQCKIEELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKDLPKASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMESLNMKIPPYVRIDLFQIILTQSISGDQRFINWTLRVASVHGLTSQLPFIKSIEVSFSDNHNYKDAVLDKQPFLMKRRTARNETFDIFFKVNYSDGCDCVSTQLSLPFEFKISTEEHVEIIDKEAVLQSLREKAVEESSCGQSGVVERRVVSEPRSEAVVYATVTSLRTYHSQQSLLANGDLKWKLEGSGTSRKRSRTGKRKSKALAEETKA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict14in Ref. 4; AAP68206 and 5; BAE99436

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF283757
EMBL· GenBank· DDBJ
AAG44850.1
EMBL· GenBank· DDBJ
mRNA
AB009050
EMBL· GenBank· DDBJ
BAB09243.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED96677.1
EMBL· GenBank· DDBJ
Genomic DNA
BT008767
EMBL· GenBank· DDBJ
AAP68206.1
EMBL· GenBank· DDBJ
mRNA
AK227432
EMBL· GenBank· DDBJ
BAE99436.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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