Q9F8A8 · COOS2_CARHZ

Function

function

CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 3 [4Fe-4S] clusters per homodimer.
[Ni-4Fe-5S] cluster (UniProtKB | Rhea| CHEBI:177874 )

Note: Binds 2 [Ni-4Fe-5S] clusters per homodimer.

Activity regulation

Inactivated by O2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site39[4Fe-4S] cluster 1 (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site47[4Fe-4S] cluster 1 (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site48[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site51[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site56[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site70[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site261[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)
Binding site295[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)
Binding site333[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)
Binding site446[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)
Binding site476[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)
Binding site526[Ni-4Fe-5S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-monoxide dehydrogenase (acceptor) activity
Molecular Functioncarbon-monoxide dehydrogenase (ferredoxin) activity
Molecular Functionhydroxylamine reductase activity
Molecular Functionnickel cation binding
Molecular Functionperoxidase activity
Biological Processgeneration of precursor metabolites and energy
Biological Processresponse to hydrogen peroxide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbon monoxide dehydrogenase 2
  • EC number
  • Short names
    CODH 2

Gene names

    • Name
      cooS2
    • Synonyms
      cooSII
    • Ordered locus names
      CHY_0085

Organism names

Accessions

  • Primary accession
    Q9F8A8
  • Secondary accessions
    • Q3AFX7
    • Q9F8L4

Proteomes

Subcellular Location

Cytoplasm
Cell membrane
; Peripheral membrane protein
Note: Loosely attached to the membrane, probably via CooF.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001571382-636Carbon monoxide dehydrogenase 2

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Domain

Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    636
  • Mass (Da)
    66,914
  • Last updated
    2007-01-23 v4
  • Checksum
    61C1011E86022A63
MAKQNLKSTDRAVQQMLDKAKREGIQTVWDRYEAMKPQCGFGETGLCCRHCLQGPCRINPFGDEPKVGICGATAEVIVARGLDRSIAAGAAGHSGHAKHLAHTLKKAVQGKAASYMIKDRTKLHSIAKRLGIPTEGQKDEDIALEVAKAALADFHEKDTPVLWVTTVLPPSRVKVLSAHGLIPAGIDHEIAEIMHRTSMGCDADAQNLLLGGLRCSLADLAGCYMGTDLADILFGTPAPVVTESNLGVLKADAVNVAVHGHNPVLSDIIVSVSKEMENEARAAGATGINVVGICCTGNEVLMRHGIPACTHSVSQEMAMITGALDAMILDYQCIQPSVATIAECTGTTVITTMEMSKITGATHVNFAEEAAVENAKQILRLAIDTFKRRKGKPVEIPNIKTKVVAGFSTEAIINALSKLNANDPLKPLIDNVVNGNIRGVCLFAGCNNVKVPQDQNFTTIARKLLKQNVLVVATGCGAGALMRHGFMDPANVDELCGDGLKAVLTAIGEANGLGGPLPPVLHMGSCVDNSRAVALVAALANRLGVDLDRLPVVASAAEAMHEKAVAIGTWAVTIGLPTHIGVLPPITGSLPVTQILTSSVKDITGGYFIVELDPETAADKLLAAINERRAGLGLPW

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict528in Ref. 1; AAG29809
Sequence conflict532in Ref. 1; AAG29809
Sequence conflict544in Ref. 1; AAG29809
Sequence conflict547in Ref. 1; AAG29809
Sequence conflict558in Ref. 1; AAG29809
Sequence conflict583in Ref. 1; AAG29809
Sequence conflict615-617in Ref. 1; AAG29809
Sequence conflict636in Ref. 1; AAG29809

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF249899
EMBL· GenBank· DDBJ
AAG29809.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000141
EMBL· GenBank· DDBJ
ABB15588.1
EMBL· GenBank· DDBJ
Genomic DNA
AF244619
EMBL· GenBank· DDBJ
AAG23568.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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