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Q9EV35 · Q9EV35_STAAU

  • Protein
    Diaminopimelate decarboxylase
  • Gene
    lysA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

142150100150200250300350400
Type
IDPosition(s)Description
Binding site237pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site279-282pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site282substrate
Binding site319substrate
Binding site323substrate
Active site349Proton donor
Binding site350substrate
Binding site379pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site379substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      ACR74_12770
      , C0102_02315
      , DQU50_03160
      , DQU51_15410
      , EIG96_14835
      , EP54_10075
      , EQ90_12905
      , G0Z31_10065
      , G6Y24_07545
      , GO793_15065
      , GO814_02515
      , GO941_17265
      , GO942_13735
      , GQX37_10950
      , GQX52_05095
      , GZ111_001235
      , HMPREF3211_00430
      , LB359_09320
      , M1K003_0243
      , SAMEA1029512_01709
      , SAMEA1029528_00018
      , SAMEA1029536_02725
      , SAMEA2078260_01837
      , SAMEA2078588_02728
      , SAMEA2080344_02703
      , SAMEA2081063_02748
      , SAMEA4008575_02191
      , SAMEA4552975_00500
      , SAMEA70146418_02537
      , SAMEA70153168_00464

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 8325-4
    • CA15
    • M121
    • MRSA_S20
    • PSS7673
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    Q9EV35
  • Secondary accessions
    • A0A1E8XDU4

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue62N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-285Orn/DAP/Arg decarboxylase 2 N-terminal
Domain286-377Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    421
  • Mass (Da)
    47,035
  • Last updated
    2001-03-01 v1
  • MD5 Checksum
    8E84C287E7FE07D2C1F86A2862A3E12E
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQLDVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFIQTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGIKYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRTALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDGKAREVIKRQSLRQLIINDTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF306669
EMBL· GenBank· DDBJ
AAG42251.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPI010000001
EMBL· GenBank· DDBJ
CAA4073168.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTOE010000011
EMBL· GenBank· DDBJ
CAA4132045.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPG010000028
EMBL· GenBank· DDBJ
CAA4183413.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTQT010000009
EMBL· GenBank· DDBJ
CAA4382549.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTWD010000025
EMBL· GenBank· DDBJ
CAA4707950.1
EMBL· GenBank· DDBJ
Genomic DNA
CACUNS010000025
EMBL· GenBank· DDBJ
CAA6130792.1
EMBL· GenBank· DDBJ
Genomic DNA
CACURZ010000023
EMBL· GenBank· DDBJ
CAA6393094.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIGXB010000009
EMBL· GenBank· DDBJ
CAC5804381.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIHOM010000001
EMBL· GenBank· DDBJ
CAC6985358.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGN010000001
EMBL· GenBank· DDBJ
CAC8216143.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGD010000012
EMBL· GenBank· DDBJ
CAC8233607.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000001
EMBL· GenBank· DDBJ
GBV19278.1
EMBL· GenBank· DDBJ
Genomic DNA
LALJ01000036
EMBL· GenBank· DDBJ
KMR35438.1
EMBL· GenBank· DDBJ
Genomic DNA
LALQ01000041
EMBL· GenBank· DDBJ
KMR56600.1
EMBL· GenBank· DDBJ
Genomic DNA
LFVK01000011
EMBL· GenBank· DDBJ
KSA74922.1
EMBL· GenBank· DDBJ
Genomic DNA
LRQH01000042
EMBL· GenBank· DDBJ
KXA38970.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIUEN010000073
EMBL· GenBank· DDBJ
MCE3362537.1
EMBL· GenBank· DDBJ
Genomic DNA
WPRH01000802
EMBL· GenBank· DDBJ
MVI57164.1
EMBL· GenBank· DDBJ
Genomic DNA
WPTS01000018
EMBL· GenBank· DDBJ
MVK34004.1
EMBL· GenBank· DDBJ
Genomic DNA
WPVZ01000960
EMBL· GenBank· DDBJ
MVL47185.1
EMBL· GenBank· DDBJ
Genomic DNA
WPXC01000033
EMBL· GenBank· DDBJ
MVM11723.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000033
EMBL· GenBank· DDBJ
NGK21841.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000193
EMBL· GenBank· DDBJ
NGW67344.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANEC010000113
EMBL· GenBank· DDBJ
NUY13029.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000049
EMBL· GenBank· DDBJ
NUY68026.1
EMBL· GenBank· DDBJ
Genomic DNA
PKSU01000002
EMBL· GenBank· DDBJ
PZL81057.1
EMBL· GenBank· DDBJ
Genomic DNA
RQSX01000458
EMBL· GenBank· DDBJ
RZH90175.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXH01000001
EMBL· GenBank· DDBJ
TXL38843.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXF01000002
EMBL· GenBank· DDBJ
TXL46832.1
EMBL· GenBank· DDBJ
Genomic DNA
CP152420
EMBL· GenBank· DDBJ
XAJ30666.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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