Q9EV35 · Q9EV35_STAAU
- ProteinDiaminopimelate decarboxylase
- GenelysA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids421 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Catalytic activity
- meso-2,6-diaminoheptanedioate + H+ = L-lysine + CO2
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 237 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 279-282 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 282 | substrate | |||
Binding site | 319 | substrate | |||
Binding site | 323 | substrate | |||
Active site | 349 | Proton donor | |||
Binding site | 350 | substrate | |||
Binding site | 379 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 379 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | diaminopimelate decarboxylase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate decarboxylase
- EC number
- Short namesDAP decarboxylase ; DAPDC
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ9EV35
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 62 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 36-285 | Orn/DAP/Arg decarboxylase 2 N-terminal | |||
Domain | 286-377 | Orn/DAP/Arg decarboxylase 2 C-terminal | |||
Sequence similarities
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length421
- Mass (Da)47,035
- Last updated2001-03-01 v1
- MD5 Checksum8E84C287E7FE07D2C1F86A2862A3E12E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF306669 EMBL· GenBank· DDBJ | AAG42251.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000001 EMBL· GenBank· DDBJ | CAA4073168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000011 EMBL· GenBank· DDBJ | CAA4132045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000028 EMBL· GenBank· DDBJ | CAA4183413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTQT010000009 EMBL· GenBank· DDBJ | CAA4382549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000025 EMBL· GenBank· DDBJ | CAA4707950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000025 EMBL· GenBank· DDBJ | CAA6130792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000023 EMBL· GenBank· DDBJ | CAA6393094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000009 EMBL· GenBank· DDBJ | CAC5804381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIHOM010000001 EMBL· GenBank· DDBJ | CAC6985358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGN010000001 EMBL· GenBank· DDBJ | CAC8216143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000012 EMBL· GenBank· DDBJ | CAC8233607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BDVT01000001 EMBL· GenBank· DDBJ | GBV19278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000036 EMBL· GenBank· DDBJ | KMR35438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000041 EMBL· GenBank· DDBJ | KMR56600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000011 EMBL· GenBank· DDBJ | KSA74922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRQH01000042 EMBL· GenBank· DDBJ | KXA38970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIUEN010000073 EMBL· GenBank· DDBJ | MCE3362537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPRH01000802 EMBL· GenBank· DDBJ | MVI57164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000018 EMBL· GenBank· DDBJ | MVK34004.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPVZ01000960 EMBL· GenBank· DDBJ | MVL47185.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000033 EMBL· GenBank· DDBJ | MVM11723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJIY010000033 EMBL· GenBank· DDBJ | NGK21841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALTR010000193 EMBL· GenBank· DDBJ | NGW67344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANEC010000113 EMBL· GenBank· DDBJ | NUY13029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANDN010000049 EMBL· GenBank· DDBJ | NUY68026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000002 EMBL· GenBank· DDBJ | PZL81057.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQSX01000458 EMBL· GenBank· DDBJ | RZH90175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXH01000001 EMBL· GenBank· DDBJ | TXL38843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXF01000002 EMBL· GenBank· DDBJ | TXL46832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP152420 EMBL· GenBank· DDBJ | XAJ30666.1 EMBL· GenBank· DDBJ | Genomic DNA |