Q9ESL4 · M3K20_MOUSE
- ProteinMitogen-activated protein kinase kinase kinase 20
- GeneMap3k20
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids802 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for Q9ESL4
The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species.
- CategoriesSequences
- SourceMGI: 2443258
Cited inMapped toGenetic determinants of micronucleus formation in vivo.
- CategoriesFunction
- SourceMGI: 2443258
Myofibrillar myopathy hallmarks associated with ZAK deficiency.
- AnnotationMyofibrillar myopathy hallmarks associated with ZAK deficiency.
- CategoriesFunction
- SourceGeneRif: 65964
ZAKbeta is activated by cellular compression and mediates contraction- induced MAP kinase signaling in skeletal muscle.
- AnnotationZAKbeta is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.
- CategoriesFunction, Subcellular Location
Targeted inhibition of ZAK ameliorates renal interstitial fibrosis.
- AnnotationTargeted inhibition of ZAK ameliorates renal interstitial fibrosis.
- CategoriesFunction, Expression
- SourceGeneRif: 65964
Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.
- AnnotationExome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6 Zak Gpr155 and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
- CategoriesSequences, Phenotypes & Variants
Identification of transcripts with enriched expression in the developing and adult pancreas.
- CategoriesExpression
- SourceMGI: 2443258
Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.
- AnnotationMixed lineage kinase 7 (MLK7) a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik) encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.
- CategoriesFunction
- SourceGeneRif: 65964
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase- like mitogen-activated protein triple kinase alpha.
- AnnotationResults show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28.
- CategoriesPTM / Processing
- SourceGeneRif: 65964
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
- CategoriesPhenotypes & Variants
- SourceMGI: 2443258
Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.
- AnnotationPKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway
- CategoriesPTM / Processing, Interaction
- SourceGeneRif: 65964
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
- CategoriesSequences
- SourceMGI: 2443258