Q9ES72 · CCN1_RAT

  • Protein
    CCN family member 1
  • Gene
    Ccn1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity).
CCN1-mediated gene regulation is dependent on heparin-binding (By similarity).
Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity).
Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functionextracellular matrix binding
Molecular Functiongrowth factor binding
Molecular Functionheparin binding
Molecular Functionintegrin binding
Biological Processapoptotic process
Biological Processapoptotic process involved in heart morphogenesis
Biological Processatrial septum morphogenesis
Biological Processatrioventricular valve morphogenesis
Biological Processcell adhesion
Biological Processcell-cell adhesion
Biological Processcellular response to angiotensin
Biological Processcellular response to hypoxia
Biological Processcellular response to norepinephrine stimulus
Biological Processcellular response to tumor necrosis factor
Biological Processchemotaxis
Biological Processchondroblast differentiation
Biological Processchorio-allantoic fusion
Biological Processextracellular matrix organization
Biological Processintussusceptive angiogenesis
Biological Processlabyrinthine layer blood vessel development
Biological Processnegative regulation of apoptotic process
Biological Processosteoblast differentiation
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of BMP signaling pathway
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of cartilage development
Biological Processpositive regulation of cell differentiation
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell-substrate adhesion
Biological Processpositive regulation of cellular senescence
Biological Processpositive regulation of ceramide biosynthetic process
Biological Processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-17 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of osteoblast proliferation
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
Biological Processpositive regulation of tumor necrosis factor production
Biological Processreactive oxygen species metabolic process
Biological Processregulation of ERK1 and ERK2 cascade
Biological Processsignal transduction
Biological Processventricular septum development
Biological Processwound healing, spreading of cells

Keywords

Enzyme and pathway databases

    • R-RNO-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    • R-RNO-8957275Post-translational protein phosphorylation

Names & Taxonomy

Protein names

  • Recommended name
    CCN family member 1
  • Alternative names
    • Cellular communication network factor 1
    • Cysteine-rich angiogenic inducer 61
    • Insulin-like growth factor-binding protein 10 (IBP-10; IGF-binding protein 10; IGFBP-10)
    • Protein CYR61

Gene names

    • Name
      Ccn1
    • Synonyms
      Cyr61
      , Igfbp10

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9ES72

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000001440025-379CCN family member 1
Disulfide bond26↔50
Disulfide bond30↔52
Disulfide bond32↔53
Disulfide bond39↔56
Disulfide bond64↔78
Disulfide bond70↔91
Modified residue184Phosphoserine
Disulfide bond284↔321
Disulfide bond301↔335
Disulfide bond312↔351
Disulfide bond315↔353
Disulfide bond320↔357

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-94IGFBP N-terminal
Domain98-164VWFC
Domain226-271TSP type-1
Region277-313Heparin-binding
Domain284-358CTCK

Sequence similarities

Belongs to the CCN family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    379
  • Mass (Da)
    41,687
  • Last updated
    2001-03-01 v1
  • Checksum
    62BF0BBA4C5AFDE9
MSSSTIKTLAVAVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDSLDDQDDLLGFDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLYNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNSECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F7FNA9F7FNA9_RATCcn1475

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF218568
EMBL· GenBank· DDBJ
AAG14964.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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