Q9ERW3 · FGF13_RAT

  • Protein
    Fibroblast growth factor 13
  • Gene
    Fgf13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity).
Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity).
Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).
Regulates voltage-gated sodium channel transport and function (By similarity).
May also play a role in MAPK signaling (By similarity).
Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentfilopodium
Cellular Componentgrowth cone
Cellular Componentintercalated disc
Cellular Componentlateral plasma membrane
Cellular Componentmicrotubule
Cellular Componentneuron projection
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentsarcolemma
Molecular Functionbeta-tubulin binding
Molecular Functiongrowth factor activity
Molecular Functionmicrotubule binding
Molecular Functionsodium channel regulator activity
Molecular Functiontransmembrane transporter binding
Biological Processbranching morphogenesis of a nerve
Biological Processcerebral cortex cell migration
Biological Processestablishment of neuroblast polarity
Biological Processhippocampus development
Biological Processinhibitory synapse assembly
Biological Processlearning
Biological Processlearning or memory
Biological ProcessMAPK cascade
Biological Processmemory
Biological Processmicrotubule polymerization
Biological Processnegative regulation of collateral sprouting
Biological Processnegative regulation of microtubule depolymerization
Biological Processneurogenesis
Biological Processneuron migration
Biological Processpositive regulation of voltage-gated sodium channel activity
Biological Processprotein localization to plasma membrane
Biological Processregulation of cardiac muscle cell action potential involved in regulation of contraction
Biological Processresponse to odorant
Biological Processsodium ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fibroblast growth factor 13
  • Short names
    FGF-13

Gene names

    • Name
      Fgf13

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9ERW3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004192081-245Fibroblast growth factor 13
Modified residue208Phosphoserine

Post-translational modification

May be phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SCN8A; regulates SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-36Disordered
Region1-62Mediates targeting to the nucleus
Region67-201Mediates interaction with sodium channels
Region213-245Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9ERW3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    245
  • Mass (Da)
    27,588
  • Last updated
    2012-10-03 v2
  • Checksum
    5B96D41AC3A3DF78
MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST

Q9ERW3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-62: MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRP → MALLRKSYS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2JZ77A0A0G2JZ77_RATFgf13199
A0A8I5ZYF4A0A8I5ZYF4_RATFgf13255

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0441331-62in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF271786
EMBL· GenBank· DDBJ
AAG15492.1
EMBL· GenBank· DDBJ
mRNA
AABR06108696
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06108697
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06108698
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06108699
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06108700
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH474019
EMBL· GenBank· DDBJ
EDL86166.1
EMBL· GenBank· DDBJ
Genomic DNA
CH474019
EMBL· GenBank· DDBJ
EDL86169.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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