Q9ERR7 · SEP15_MOUSE

  • Protein
    Selenoprotein F
  • Gene
    Selenof
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

May be involved in redox reactions associated with the formation of disulfide bonds (By similarity).
May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum lumen
Biological Process'de novo' post-translational protein folding
Biological Processresponse to lipopolysaccharide

Names & Taxonomy

Protein names

  • Recommended name
    Selenoprotein F
  • Alternative names
    • 15 kDa selenoprotein

Gene names

    • Name
      Selenof
    • Synonyms
      Sep15

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9ERR7
  • Secondary accessions
    • Q3TXW1
    • Q544W8
    • Q8VE40

Proteomes

Organism-specific databases

Subcellular Location

Note: The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_000002230829-162Selenoprotein F

Proteomic databases

PTM databases

Interaction

Subunit

Forms a tight complex with UGGT1/UGCGL1 (PubMed:11278576).
Interacts with UGGT2/UGCGL2 (By similarity).
Interacts with RDH11 (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the selenoprotein M/F family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    162
  • Mass (Da)
    17,806
  • Last updated
    2008-02-26 v3
  • Checksum
    6EFF88F68C81903C
MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFASEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4J0K1A0A0R4J0K1_MOUSESelenof162
A0A1C7ZMY4A0A1C7ZMY4_MOUSESelenof121
A0A0G2JEF3A0A0G2JEF3_MOUSESelenof45

Features

Showing features for sequence conflict, non-standard residue.

Type
IDPosition(s)Description
Sequence conflict26in Ref. 1; AAG31765 and 2; BAE35012/BAC55255
Non-standard residue93Selenocysteine
Sequence conflict98in Ref. 3; AAH19792

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF288740
EMBL· GenBank· DDBJ
AAG31765.1
EMBL· GenBank· DDBJ
mRNA
AK020419
EMBL· GenBank· DDBJ
BAC55255.1
EMBL· GenBank· DDBJ
mRNA
AK159085
EMBL· GenBank· DDBJ
BAE34803.1
EMBL· GenBank· DDBJ
mRNA
AK159353
EMBL· GenBank· DDBJ
BAE35012.1
EMBL· GenBank· DDBJ
mRNA
BC019792
EMBL· GenBank· DDBJ
AAH19792.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp