Q9ER71 · RHOJ_MOUSE
- ProteinRho-related GTP-binding protein RhoJ
- GeneRhoj
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids214 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plasma membrane-associated small GTPase specifically involved in angiogenesis (By similarity).
Required for endothelial cell migration during vascular development via its interaction with GLUL (By similarity).
Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:10967094).
Required for endothelial cell migration during vascular development via its interaction with GLUL (By similarity).
Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:10967094).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31-36 | GTP (UniProtKB | ChEBI) | ||||
Sequence: AVGKTC | ||||||
Binding site | 46-53 | GTP (UniProtKB | ChEBI) | ||||
Sequence: FPEEYVPT | ||||||
Binding site | 75-79 | GTP (UniProtKB | ChEBI) | ||||
Sequence: DTAGQ | ||||||
Binding site | 133-136 | GTP (UniProtKB | ChEBI) | ||||
Sequence: TQID | ||||||
Binding site | 177-178 | GTP (UniProtKB | ChEBI) | ||||
Sequence: AL |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | protein kinase binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | actin filament organization | |
Biological Process | angiogenesis | |
Biological Process | Cdc42 protein signal transduction | |
Biological Process | endocytosis | |
Biological Process | establishment or maintenance of cell polarity | |
Biological Process | positive regulation of cell migration involved in sprouting angiogenesis | |
Biological Process | regulation of cell shape | |
Biological Process | regulation of endothelial cell migration | |
Biological Process | regulation of sprouting angiogenesis | |
Biological Process | retina vasculature morphogenesis in camera-type eye | |
Biological Process | Rho protein signal transduction |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-related GTP-binding protein RhoJ
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9ER71
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor
Note: Localization to the plasma membrane is regulated by GLUL.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, lipidation, modified residue, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000198870 | 1-211 | Rho-related GTP-binding protein RhoJ | |||
Sequence: MSCRERTDSSCGCNGHEENRILKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELKDCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKKKKKGCLGCHGCC | ||||||
Lipidation | 3 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Lipidation | 11 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Modified residue | 211 | Cysteine methyl ester | ||||
Sequence: C | ||||||
Lipidation | 211 | S-farnesyl cysteine | ||||
Sequence: C | ||||||
Propeptide | PRO_0000281221 | 212-214 | Removed in mature form | |||
Sequence: AII |
Post-translational modification
Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL.
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 50-58 | Effector region | ||||
Sequence: YVPTVFDHY |
Sequence similarities
Belongs to the small GTPase superfamily. Rho family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q9ER71-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length214
- Mass (Da)23,766
- Last updated2002-10-25 v2
- ChecksumA8070C73583A8AA3
Q9ER71-2
- Name2
- Differences from canonical
- 4-13: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_005709 | 4-13 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 166 | in Ref. 3; AAL09441 | ||||
Sequence: A → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ276568 EMBL· GenBank· DDBJ | CAC06700.1 EMBL· GenBank· DDBJ | mRNA | ||
AB060651 EMBL· GenBank· DDBJ | BAB91069.1 EMBL· GenBank· DDBJ | mRNA | ||
AF309564 EMBL· GenBank· DDBJ | AAL09441.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003482 EMBL· GenBank· DDBJ | BAB22812.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003490 EMBL· GenBank· DDBJ | BAB22818.1 EMBL· GenBank· DDBJ | mRNA | ||
AK156619 EMBL· GenBank· DDBJ | BAE33778.1 EMBL· GenBank· DDBJ | mRNA | ||
AK159385 EMBL· GenBank· DDBJ | BAE35040.1 EMBL· GenBank· DDBJ | mRNA | ||
BC043719 EMBL· GenBank· DDBJ | AAH43719.1 EMBL· GenBank· DDBJ | mRNA |