Q9EQH5 · CTBP2_RAT

  • Protein
    C-terminal-binding protein 2
  • Gene
    Ctbp2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity).

Features

Showing features for binding site, active site.

144550100150200250300350400
TypeIDPosition(s)Description
Binding site106NAD+ (UniProtKB | ChEBI)
Binding site186-191NAD+ (UniProtKB | ChEBI)
Binding site210NAD+ (UniProtKB | ChEBI)
Binding site243-249NAD+ (UniProtKB | ChEBI)
Binding site270-272NAD+ (UniProtKB | ChEBI)
Active site272
Binding site296NAD+ (UniProtKB | ChEBI)
Active site301
Active site321Proton donor
Binding site321-324NAD+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentnucleus
Cellular Componentphotoreceptor ribbon synapse
Cellular Componentpresynaptic active zone cytoplasmic component
Cellular Componentpresynaptic cytosol
Cellular Componentribbon synapse
Cellular Componentsynapse
Cellular Componenttranscription repressor complex
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription factor binding
Molecular FunctionNAD binding
Molecular Functionnuclear retinoic acid receptor binding
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Functionprotein kinase binding
Molecular Functionprotein-containing complex binding
Molecular Functionstructural constituent of presynaptic active zone
Molecular Functiontranscription coactivator activity
Molecular Functiontranscription coregulator binding
Molecular Functiontranscription corepressor activity
Molecular Functiontranscription corepressor binding
Biological Processcellular response to leukemia inhibitory factor
Biological Processnegative regulation of DNA-templated transcription
Biological Processpositive regulation of retinoic acid receptor signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II
Biological Processsynaptic vesicle docking
Biological Processwhite fat cell differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    C-terminal-binding protein 2
  • Short names
    CtBP2

Gene names

    • Name
      Ctbp2

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9EQH5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002993561-445C-terminal-binding protein 2
Modified residue22Asymmetric dimethylarginine
Modified residue428Phosphoserine; by HIPK2

Post-translational modification

Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 2 is specifically localized in synaptic ribbon (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with HIPK2, ZNF217 and PNN (By similarity).
Interacts with the transcription factors BKLF, delta EF1/AREB6/ZEB, EVI-1 and Friend of GATA (FOG) via the consensus motif P-X-[DNS]-L-[STVA]. Can form a complex with BKLF on a CACCC-box oligonucleotide. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with NRIP1 and WIZ. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity).
Interacts with MCRIP1 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region414-445Disordered
Compositional bias418-433Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9EQH5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    445
  • Mass (Da)
    48,987
  • Last updated
    2007-09-11 v2
  • Checksum
    403012CDEB2E492B
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSTPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ

Q9EQH5-2

  • Name
    2
  • Synonyms
    Ribeye
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGEGVWCELVNHRAQDTESCLSREAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDYYGDPSRGTRVPKEPPFYRDPGTSRPVPSYGVLGSRIPWEQVQGQLPALQDAGHLYRESGSKTVLHGQRTHCRAPSPGRYGREQPDSRLGIEVPTYSPNSSQVYNDICERPVDSTHARQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRESIHSKLAYENYEADLSTFQGPGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLEDADIKSVAPNLGQARVLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTALQFHPAGPLQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCALTARLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPHASPQLLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPS

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6ALN3A0A8I6ALN3_RATCtbp2432
A0A8I6AEI5A0A8I6AEI5_RATCtbp2406
A0A8L2QC65A0A8L2QC65_RATCtbp2464

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0276111-20in isoform 2
Compositional bias418-433Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF222712
EMBL· GenBank· DDBJ
AAG45952.1
EMBL· GenBank· DDBJ
mRNA
AABR03001613
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03000195
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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