Q9EQH5 · CTBP2_RAT
- ProteinC-terminal-binding protein 2
- GeneCtbp2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids445 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity).
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 106 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 186-191 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: IGFGRT | ||||||
Binding site | 210 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 243-249 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: CNLNEHN | ||||||
Binding site | 270-272 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: AAR | ||||||
Active site | 272 | |||||
Sequence: R | ||||||
Binding site | 296 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 301 | |||||
Sequence: E | ||||||
Active site | 321 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 321-324 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: HTAW |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-terminal-binding protein 2
- Short namesCtBP2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9EQH5
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000299356 | 1-445 | C-terminal-binding protein 2 | |||
Sequence: MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSTPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ | ||||||
Modified residue | 22 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 428 | Phosphoserine; by HIPK2 | ||||
Sequence: S |
Post-translational modification
Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with HIPK2, ZNF217 and PNN (By similarity).
Interacts with the transcription factors BKLF, delta EF1/AREB6/ZEB, EVI-1 and Friend of GATA (FOG) via the consensus motif P-X-[DNS]-L-[STVA]. Can form a complex with BKLF on a CACCC-box oligonucleotide. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with NRIP1 and WIZ. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity).
Interacts with MCRIP1 (By similarity).
Interacts with the transcription factors BKLF, delta EF1/AREB6/ZEB, EVI-1 and Friend of GATA (FOG) via the consensus motif P-X-[DNS]-L-[STVA]. Can form a complex with BKLF on a CACCC-box oligonucleotide. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with NRIP1 and WIZ. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity).
Interacts with MCRIP1 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 414-445 | Disordered | ||||
Sequence: THNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ | ||||||
Compositional bias | 418-433 | Polar residues | ||||
Sequence: PTVAHPSQAPSPNQPT |
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9EQH5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length445
- Mass (Da)48,987
- Last updated2007-09-11 v2
- Checksum403012CDEB2E492B
Q9EQH5-2
- Name2
- SynonymsRibeye
- Differences from canonical
- 1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGEGVWCELVNHRAQDTESCLSREAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDYYGDPSRGTRVPKEPPFYRDPGTSRPVPSYGVLGSRIPWEQVQGQLPALQDAGHLYRESGSKTVLHGQRTHCRAPSPGRYGREQPDSRLGIEVPTYSPNSSQVYNDICERPVDSTHARQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRESIHSKLAYENYEADLSTFQGPGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLEDADIKSVAPNLGQARVLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTALQFHPAGPLQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCALTARLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPHASPQLLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPS
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6ALN3 | A0A8I6ALN3_RAT | Ctbp2 | 432 | ||
A0A8I6AEI5 | A0A8I6AEI5_RAT | Ctbp2 | 406 | ||
A0A8L2QC65 | A0A8L2QC65_RAT | Ctbp2 | 464 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_027611 | 1-20 | in isoform 2 | |||
Sequence: MALVDKHKVKRQRLDRICEG → MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGEGVWCELVNHRAQDTESCLSREAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDYYGDPSRGTRVPKEPPFYRDPGTSRPVPSYGVLGSRIPWEQVQGQLPALQDAGHLYRESGSKTVLHGQRTHCRAPSPGRYGREQPDSRLGIEVPTYSPNSSQVYNDICERPVDSTHARQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRESIHSKLAYENYEADLSTFQGPGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLEDADIKSVAPNLGQARVLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTALQFHPAGPLQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCALTARLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPHASPQLLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPS | ||||||
Compositional bias | 418-433 | Polar residues | ||||
Sequence: PTVAHPSQAPSPNQPT |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF222712 EMBL· GenBank· DDBJ | AAG45952.1 EMBL· GenBank· DDBJ | mRNA | ||
AABR03001613 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03000195 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |