Q9EQ16 · CXCR6_MOUSE
- ProteinC-X-C chemokine receptor type 6
- GeneCxcr6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids351 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Receptor for the C-X-C chemokine CXCL16.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Molecular Function | C-C chemokine binding | |
Molecular Function | C-C chemokine receptor activity | |
Molecular Function | C-X-C chemokine binding | |
Molecular Function | C-X-C chemokine receptor activity | |
Molecular Function | coreceptor activity | |
Biological Process | calcium-mediated signaling | |
Biological Process | cell chemotaxis | |
Biological Process | immune response | |
Biological Process | inflammatory response | |
Biological Process | positive regulation of cytosolic calcium ion concentration |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-X-C chemokine receptor type 6
- Short namesCXC-R6; CXCR-6
- CD Antigen Name
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9EQ16
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-41 | Extracellular | ||||
Sequence: MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEV | ||||||
Transmembrane | 42-68 | Helical; Name=1 | ||||
Sequence: FLPCVYLVVFVFGLLGNSLVLIIYIFY | ||||||
Topological domain | 69-77 | Cytoplasmic | ||||
Sequence: QKLRTLTDV | ||||||
Transmembrane | 78-98 | Helical; Name=2 | ||||
Sequence: FLLNLPLADLVFVCTLPFWAY | ||||||
Topological domain | 99-112 | Extracellular | ||||
Sequence: AGTYEWVFGTVMCK | ||||||
Transmembrane | 113-134 | Helical; Name=3 | ||||
Sequence: TLRGMYTMNFYVSMLTLTCITV | ||||||
Topological domain | 135-152 | Cytoplasmic | ||||
Sequence: DRFIVVVQATKAFNRQAK | ||||||
Transmembrane | 153-173 | Helical; Name=4 | ||||
Sequence: WKIWGQVICLLIWVVSLLVSL | ||||||
Topological domain | 174-196 | Extracellular | ||||
Sequence: PQIIYGHVQDIDKLICQYHSEEI | ||||||
Transmembrane | 197-224 | Helical; Name=5 | ||||
Sequence: STMVLVIQMTLGFFLPLLTMILCYSGII | ||||||
Topological domain | 225-240 | Cytoplasmic | ||||
Sequence: KTLLHARNFQKHKSLK | ||||||
Transmembrane | 241-268 | Helical; Name=6 | ||||
Sequence: IIFLVVAVFLLTQTPFNLAMLIQSTSWE | ||||||
Topological domain | 269-284 | Extracellular | ||||
Sequence: YYTITSFKYAIVVTEA | ||||||
Transmembrane | 285-302 | Helical; Name=7 | ||||
Sequence: IAYFRACLNPVLYAFVGL | ||||||
Topological domain | 303-351 | Cytoplasmic | ||||
Sequence: KFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSSKTCSASHNVETTSMFQL |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000303230 | 1-351 | C-X-C chemokine receptor type 6 | |||
Sequence: MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEVFLPCVYLVVFVFGLLGNSLVLIIYIFYQKLRTLTDVFLLNLPLADLVFVCTLPFWAYAGTYEWVFGTVMCKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVICLLIWVVSLLVSLPQIIYGHVQDIDKLICQYHSEEISTMVLVIQMTLGFFLPLLTMILCYSGIIKTLLHARNFQKHKSLKIIFLVVAVFLLTQTPFNLAMLIQSTSWEYYTITSFKYAIVVTEAIAYFRACLNPVLYAFVGLKFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSSKTCSASHNVETTSMFQL | ||||||
Glycosylation | 23 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 24 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 111↔189 | |||||
Sequence: CKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVICLLIWVVSLLVSLPQIIYGHVQDIDKLIC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)40,468
- Last updated2001-03-01 v1
- Checksum5658788372B4C65A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1L1SVJ3 | A0A1L1SVJ3_MOUSE | Cxcr6 | 358 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 119 | in Ref. 4; AAH96491 | ||||
Sequence: T → A | ||||||
Sequence conflict | 207 | in Ref. 2; AAG31284 | ||||
Sequence: L → R | ||||||
Sequence conflict | 305 | in Ref. 4; AAH96491 | ||||
Sequence: R → W | ||||||
Sequence conflict | 321 | in Ref. 4; AAH96491 | ||||
Sequence: L → Q | ||||||
Sequence conflict | 324 | in Ref. 4; AAH96491 | ||||
Sequence: S → P |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF301018 EMBL· GenBank· DDBJ | AAG34367.1 EMBL· GenBank· DDBJ | mRNA | ||
AF305709 EMBL· GenBank· DDBJ | AAG31284.1 EMBL· GenBank· DDBJ | mRNA | ||
AK052901 EMBL· GenBank· DDBJ | BAC35196.1 EMBL· GenBank· DDBJ | mRNA | ||
AK137703 EMBL· GenBank· DDBJ | BAE23469.1 EMBL· GenBank· DDBJ | mRNA | ||
AK153914 EMBL· GenBank· DDBJ | BAE32252.1 EMBL· GenBank· DDBJ | mRNA | ||
BC096491 EMBL· GenBank· DDBJ | AAH96491.1 EMBL· GenBank· DDBJ | mRNA |