Q9EQ16 · CXCR6_MOUSE

  • Protein
    C-X-C chemokine receptor type 6
  • Gene
    Cxcr6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Receptor for the C-X-C chemokine CXCL16.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Molecular FunctionC-C chemokine binding
Molecular FunctionC-C chemokine receptor activity
Molecular FunctionC-X-C chemokine binding
Molecular FunctionC-X-C chemokine receptor activity
Molecular Functioncoreceptor activity
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological Processimmune response
Biological Processinflammatory response
Biological Processpositive regulation of cytosolic calcium ion concentration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    C-X-C chemokine receptor type 6
  • Short names
    CXC-R6; CXCR-6
  • CD Antigen Name
    • CD186

Gene names

    • Name
      Cxcr6

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • C57BL/6NCr
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9EQ16
  • Secondary accessions
    • Q4VA95
    • Q9ERH5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-41Extracellular
Transmembrane42-68Helical; Name=1
Topological domain69-77Cytoplasmic
Transmembrane78-98Helical; Name=2
Topological domain99-112Extracellular
Transmembrane113-134Helical; Name=3
Topological domain135-152Cytoplasmic
Transmembrane153-173Helical; Name=4
Topological domain174-196Extracellular
Transmembrane197-224Helical; Name=5
Topological domain225-240Cytoplasmic
Transmembrane241-268Helical; Name=6
Topological domain269-284Extracellular
Transmembrane285-302Helical; Name=7
Topological domain303-351Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003032301-351C-X-C chemokine receptor type 6
Glycosylation23N-linked (GlcNAc...) asparagine
Glycosylation24N-linked (GlcNAc...) asparagine
Disulfide bond111↔189

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    40,468
  • Last updated
    2001-03-01 v1
  • Checksum
    5658788372B4C65A
MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEVFLPCVYLVVFVFGLLGNSLVLIIYIFYQKLRTLTDVFLLNLPLADLVFVCTLPFWAYAGTYEWVFGTVMCKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVICLLIWVVSLLVSLPQIIYGHVQDIDKLICQYHSEEISTMVLVIQMTLGFFLPLLTMILCYSGIIKTLLHARNFQKHKSLKIIFLVVAVFLLTQTPFNLAMLIQSTSWEYYTITSFKYAIVVTEAIAYFRACLNPVLYAFVGLKFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSSKTCSASHNVETTSMFQL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L1SVJ3A0A1L1SVJ3_MOUSECxcr6358

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict119in Ref. 4; AAH96491
Sequence conflict207in Ref. 2; AAG31284
Sequence conflict305in Ref. 4; AAH96491
Sequence conflict321in Ref. 4; AAH96491
Sequence conflict324in Ref. 4; AAH96491

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF301018
EMBL· GenBank· DDBJ
AAG34367.1
EMBL· GenBank· DDBJ
mRNA
AF305709
EMBL· GenBank· DDBJ
AAG31284.1
EMBL· GenBank· DDBJ
mRNA
AK052901
EMBL· GenBank· DDBJ
BAC35196.1
EMBL· GenBank· DDBJ
mRNA
AK137703
EMBL· GenBank· DDBJ
BAE23469.1
EMBL· GenBank· DDBJ
mRNA
AK153914
EMBL· GenBank· DDBJ
BAE32252.1
EMBL· GenBank· DDBJ
mRNA
BC096491
EMBL· GenBank· DDBJ
AAH96491.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp