Q9EPZ7 · SO1C1_RAT

  • Protein
    Solute carrier organic anion transporter family member 1C1
  • Gene
    Slco1c1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates the Na+-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:12923172, PubMed:17667996, PubMed:19819953).
The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5-triiodo-L-thyronine (T3) (PubMed:12923172, PubMed:17667996, PubMed:19819953).
The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:12923172).
T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:12923172).
Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)) (PubMed:12923172, PubMed:17667996, PubMed:19819953).
Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity).
May serve as a drug efflux system at the blood brain barrier (PubMed:12923172, PubMed:17667996).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.18 μML-thyroxine
0.72 μML-thyroxine
10.3 nML-thyroxine
10.7 μM17beta-estradiol 17-O-(beta-D-glucuronate)
6.1 μM17beta-estradiol 17-O-(beta-D-glucuronate)
1.3 μM17beta-estradiol 17-O-(beta-D-glucuronate)
0.76 μMtroglitazone sulfate
1.34 μMcerivastatin
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
32.1 pmol/min/mg
67 pmol/min/mg
93.4 pmol/min/mg
73 pmol/min/mg
14.5 pmol/min/mg
69 pmol/min/mg

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionbile acid transmembrane transporter activity
Molecular Functionorganic anion transmembrane transporter activity
Molecular Functionsodium-independent organic anion transmembrane transporter activity
Molecular Functionthyroid hormone transmembrane transporter activity
Biological Processbile acid and bile salt transport
Biological Processmonoatomic ion transport
Biological Processpositive regulation of thyroid hormone generation
Biological Processsodium-independent organic anion transport
Biological Processthyroid hormone transport
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier organic anion transporter family member 1C1
  • Alternative names
    • BBB-specific anion transporter type 1
      (BAST1
      )
    • Blood-brain barrier-specific anion transporter 1
    • Organic anion transporter 1C1 (OATP1C1)
    • Organic anion-transporting polypeptide 14
      (OATP-14
      )
    • Solute carrier family 21 member 14
    • Thyroxine transporter

Gene names

    • Name
      Slco1c1
    • Synonyms
      Bsat1, Oatp1c1, Oatpf, Slc21a14

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9EPZ7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Expressed in the plasma membranes of brain capillary endothelial cells.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-43Cytoplasmic
Transmembrane44-63Helical; Name=1
Topological domain64-82Extracellular
Transmembrane83-103Helical; Name=2
Topological domain104-109Cytoplasmic
Transmembrane110-134Helical; Name=3
Topological domain135-187Extracellular
Transmembrane188-216Helical; Name=4
Topological domain217-235Cytoplasmic
Transmembrane236-256Helical; Name=5
Topological domain257-274Extracellular
Transmembrane275-299Helical; Name=6
Topological domain300-352Cytoplasmic
Transmembrane353-374Helical; Name=7
Topological domain375-394Extracellular
Transmembrane395-418Helical; Name=8
Topological domain419-422Cytoplasmic
Transmembrane423-446Helical; Name=9
Topological domain447-558Extracellular
Transmembrane559-581Helical; Name=10
Topological domain582-590Cytoplasmic
Transmembrane591-616Helical; Name=11
Topological domain617-650Extracellular
Transmembrane651-668Helical; Name=12
Topological domain669-716Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001910571-716Solute carrier organic anion transporter family member 1C1
Glycosylation453N-linked (GlcNAc...) asparagine
Disulfide bond480↔510
Disulfide bond486↔506
Disulfide bond495↔527
Glycosylation524N-linked (GlcNAc...) asparagine
Glycosylation537N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in cerebral microvessels and choroid plexus (at protein level) (PubMed:12923172, PubMed:17667996, PubMed:18687783).
Brain-specific (PubMed:12923172, PubMed:17667996).
Not detected in glial cells, kidney, heart, lung, skeletal muscle, spleen, liver, nor testis (PubMed:12923172, PubMed:17667996).

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-26Disordered
Domain474-529Kazal-like

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    716
  • Mass (Da)
    78,627
  • Last updated
    2001-03-01 v1
  • Checksum
    487734B82A50A6EA
MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITAREKIVMSSSVKKETCAARDHGLQPKYWPGKETRL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GJ93A0A8I6GJ93_RATSlco1c1667
G3V795G3V795_RATSlco1c1716

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF306546
EMBL· GenBank· DDBJ
AAG37066.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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