Q9EPZ6 · TBX18_MOUSE
- ProteinT-box transcription factor TBX18
- GeneTbx18
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids613 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 149-336 | T-box | ||||
Sequence: LQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameT-box transcription factor TBX18
- Short namesT-box protein 18
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9EPZ6
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Deficient mice fail to maintain anterior-posterior polarity, resulting in abnormal dorsal-ventral polarity of the somites. Mutant mice display neonatal lethality and abnormal morphology of vertebrae, ribs, spinal nerves and coronary vessels. Besides, mutant mice develop anomalies of the urinary tract, including hydroureter and hydronephrosis.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000184447 | 1-613 | T-box transcription factor TBX18 | |||
Sequence: MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATEEAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAERSCGSRGAAGSCEDGFLQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLQGTGNAVPATHPHLLSGSSCSSPAFHLGPNTSQLCSLTPADYSACARSGLALNRYSTSLAETYSRLTNQSSETFAPPRTPSYVSVSSNPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSGNAFAANQTHQSSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLPSSQVSAHMV |
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed in the renal pelvis and ureter smooth muscle layer at 17.5 dpc (at protein level) (PubMed:26235987).
During development expression is most prominent in the proepicardial organ and in the epicardium. Expressed also in the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge and the developing limb buds (PubMed:11118889).
During development expression is most prominent in the proepicardial organ and in the epicardium. Expressed also in the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge and the developing limb buds (PubMed:11118889).
Interaction
Subunit
Homodimer. Can form a heterodimer with TBX15. Interacts with GATA4 and NKX2-5. Interacts (via engrailed homology 1 repressor motif) with TLE3; this interaction represses TBX18 transcriptional activity. Interacts with PAX3. Interacts with SIX1 (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for motif, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 18-28 | Engrailed homology 1 repressor | ||||
Sequence: HAFSVEALIGA | ||||||
Motif | 36-40 | Nuclear localization signal | ||||
Sequence: KKRRK | ||||||
Region | 37-94 | Disordered | ||||
Sequence: KRRKLATEEAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAE | ||||||
Region | 114-145 | Disordered | ||||
Sequence: ASPLASPGGSPKGSPVPGLARPGTPLPAPQAP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length613
- Mass (Da)65,464
- Last updated2001-03-01 v1
- ChecksumA9E64D395725AB38
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G3X919 | G3X919_MOUSE | Tbx18 | 613 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF306666 EMBL· GenBank· DDBJ | AAG48598.1 EMBL· GenBank· DDBJ | mRNA |