Q9EPZ6 · TBX18_MOUSE

  • Protein
    T-box transcription factor TBX18
  • Gene
    Tbx18
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.

Features

Showing features for dna binding.

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TypeIDPosition(s)Description
DNA binding149-336T-box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Cellular ComponentRNA polymerase II transcription repressor complex
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionprotein homodimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Biological Processanatomical structure formation involved in morphogenesis
Biological Processanterior/posterior axis specification
Biological Processcell differentiation
Biological Processcell fate specification
Biological Processcochlea morphogenesis
Biological Processepithelial cell proliferation
Biological Processmesenchymal cell proliferation
Biological Processmesenchymal cell proliferation involved in ureter development
Biological Processmorphogenesis of embryonic epithelium
Biological Processmyoblast proliferation
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneural plate anterior/posterior regionalization
Biological Processpositive regulation of cell-cell adhesion
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of mesenchymal cell proliferation
Biological Processpositive regulation of mesenchymal cell proliferation involved in ureter development
Biological Processpositive regulation of myoblast proliferation
Biological Processpositive regulation of stem cell proliferation
Biological Processregulation of transcription by RNA polymerase II
Biological Processsensory perception of sound
Biological Processsinoatrial node development
Biological Processsmooth muscle cell differentiation
Biological Processsomitogenesis
Biological Processstem cell differentiation
Biological Processstem cell proliferation
Biological Processureter development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-box transcription factor TBX18
  • Short names
    T-box protein 18

Gene names

    • Name
      Tbx18

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9EPZ6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Deficient mice fail to maintain anterior-posterior polarity, resulting in abnormal dorsal-ventral polarity of the somites. Mutant mice display neonatal lethality and abnormal morphology of vertebrae, ribs, spinal nerves and coronary vessels. Besides, mutant mice develop anomalies of the urinary tract, including hydroureter and hydronephrosis.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001844471-613T-box transcription factor TBX18

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed in the renal pelvis and ureter smooth muscle layer at 17.5 dpc (at protein level) (PubMed:26235987).
During development expression is most prominent in the proepicardial organ and in the epicardium. Expressed also in the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge and the developing limb buds (PubMed:11118889).

Interaction

Subunit

Homodimer. Can form a heterodimer with TBX15. Interacts with GATA4 and NKX2-5. Interacts (via engrailed homology 1 repressor motif) with TLE3; this interaction represses TBX18 transcriptional activity. Interacts with PAX3. Interacts with SIX1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif, region.

TypeIDPosition(s)Description
Motif18-28Engrailed homology 1 repressor
Motif36-40Nuclear localization signal
Region37-94Disordered
Region114-145Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    65,464
  • Last updated
    2001-03-01 v1
  • Checksum
    A9E64D395725AB38
MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATEEAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAERSCGSRGAAGSCEDGFLQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLQGTGNAVPATHPHLLSGSSCSSPAFHLGPNTSQLCSLTPADYSACARSGLALNRYSTSLAETYSRLTNQSSETFAPPRTPSYVSVSSNPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSGNAFAANQTHQSSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLPSSQVSAHMV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3X919G3X919_MOUSETbx18613

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF306666
EMBL· GenBank· DDBJ
AAG48598.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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