Q9EP79 · V1R52_MOUSE
- ProteinVomeronasal type-1 receptor 52
- GeneVmn1r52
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids309 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | pheromone receptor activity | |
Biological Process | response to pheromone | |
Biological Process | sensory perception of chemical stimulus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameVomeronasal type-1 receptor 52
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9EP79
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-19 | Extracellular | ||||
Sequence: MNKDHTLYCSVYIRNAFFS | ||||||
Transmembrane | 20-40 | Helical; Name=1 | ||||
Sequence: EIGIGISANSCLLLFHTFMFI | ||||||
Topological domain | 41-49 | Cytoplasmic | ||||
Sequence: RGHRPRLTD | ||||||
Transmembrane | 50-70 | Helical; Name=2 | ||||
Sequence: LPIGFVALIHLVMLLLAAYIT | ||||||
Topological domain | 71-93 | Extracellular | ||||
Sequence: EDFFMSSGGWDDITCKLVIFLHR | ||||||
Transmembrane | 94-114 | Helical; Name=3 | ||||
Sequence: FFRSLSVCATCLLSVFQAIIL | ||||||
Topological domain | 115-134 | Cytoplasmic | ||||
Sequence: CPQSSHLAKLKQNSPHQLSY | ||||||
Transmembrane | 135-155 | Helical; Name=4 | ||||
Sequence: FFIFLSIFYTSISSHILIAAI | ||||||
Topological domain | 156-187 | Extracellular | ||||
Sequence: PTQNITFVNLIYITNSCSFLPLSSSMQHTFST | ||||||
Transmembrane | 188-208 | Helical; Name=5 | ||||
Sequence: LLAFRNVFVIGLMGLSTCYMA | ||||||
Topological domain | 209-238 | Cytoplasmic | ||||
Sequence: TLLCRHKTRSQRLQNSKLSPKATPEQRALR | ||||||
Transmembrane | 239-259 | Helical; Name=6 | ||||
Sequence: TILMLMSFFLLMSTFDSIISY | ||||||
Topological domain | 260-268 | Extracellular | ||||
Sequence: SRTILQGNP | ||||||
Transmembrane | 269-289 | Helical; Name=7 | ||||
Sequence: LPFCFQILVAHSYAAVSPLLV | ||||||
Topological domain | 290-309 | Cytoplasmic | ||||
Sequence: LSNEKRITNLLISMYEKIVL |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 37 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000239962 | 1-309 | Vomeronasal type-1 receptor 52 | |||
Sequence: MNKDHTLYCSVYIRNAFFSEIGIGISANSCLLLFHTFMFIRGHRPRLTDLPIGFVALIHLVMLLLAAYITEDFFMSSGGWDDITCKLVIFLHRFFRSLSVCATCLLSVFQAIILCPQSSHLAKLKQNSPHQLSYFFIFLSIFYTSISSHILIAAIPTQNITFVNLIYITNSCSFLPLSSSMQHTFSTLLAFRNVFVIGLMGLSTCYMATLLCRHKTRSQRLQNSKLSPKATPEQRALRTILMLMSFFLLMSTFDSIISYSRTILQGNPLPFCFQILVAHSYAAVSPLLVLSNEKRITNLLISMYEKIVL | ||||||
Disulfide bond | 85↔172 | |||||
Sequence: CKLVIFLHRFFRSLSVCATCLLSVFQAIILCPQSSHLAKLKQNSPHQLSYFFIFLSIFYTSISSHILIAAIPTQNITFVNLIYITNSC | ||||||
Glycosylation | 159 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)35,050
- Last updated2001-03-01 v1
- Checksum918D81704C2EF267
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3BQJ2 | A0A2I3BQJ2_MOUSE | Vmn1r52 | 130 | ||
A0A2I3BQW2 | A0A2I3BQW2_MOUSE | Vmn1r52 | 121 | ||
A0A2I3BRC4 | A0A2I3BRC4_MOUSE | Vmn1r52 | 109 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF291486 EMBL· GenBank· DDBJ | AAG42080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF129005 EMBL· GenBank· DDBJ | AAG43250.1 EMBL· GenBank· DDBJ | Genomic DNA |