Q9EP41 · Q9EP41_9RETR
- ProteinPol polyprotein
- Genepol
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1148 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Catalytic activity
- Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 1098-1146 | Integrase-type | ||||
Sequence: KFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIK |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | DNA binding | |
Molecular Function | exoribonuclease H activity | |
Molecular Function | RNA-directed DNA polymerase activity | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA integration | |
Biological Process | DNA recombination | |
Biological Process | establishment of integrated proviral latency | |
Biological Process | proteolysis | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral genome integration into host DNA |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePol polyprotein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus
Accessions
- Primary accessionQ9EP41
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 12-79 | Disordered | ||||
Sequence: CSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVSRSERNKKGIQCQGEGSSRSRGSQPGQ | ||||||
Compositional bias | 26-48 | Polar residues | ||||
Sequence: ETNFPDTTEESAQQICCTRDSSD | ||||||
Compositional bias | 62-79 | Polar residues | ||||
Sequence: IQCQGEGSSRSRGSQPGQ | ||||||
Domain | 102-176 | Peptidase A2 | ||||
Sequence: LNVLLDTGADTSVLTTAHYNRLKYRGKKYQGTGIIGVGGNVETFSTPVTIKKKGRYIKTRMLVADIPVTILGRDI | ||||||
Domain | 232-421 | Reverse transcriptase | ||||
Sequence: EGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWNCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILLEKGFETPDDKLQEVPPYSWLGYQL | ||||||
Domain | 619-742 | RNase H type-1 | ||||
Sequence: PTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDIRDKQVNIVTDSYYCWKNITEGLGLEGPQSPWWPIIQNIREKEIVYFAWVPGHKGIYGNQLADEAAKIKEE | ||||||
Domain | 880-921 | Integrase-type | ||||
Sequence: ENIQEAQEEHENWHTSPKILARNYKIPLTVAKQITQECPHCT | ||||||
Domain | 923-1080 | Integrase catalytic | ||||
Sequence: QGSGPAGCVMRSPNHWQADCTHLDNKIILTFVESNSGYIHATLLSKENALCTSLAMLEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDSTQTLEAALQLALITCNKGRESMGRQTPWEVFITNQ | ||||||
Domain | 1098-1146 | Integrase-type | ||||
Sequence: KFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIK |
Sequence similarities
Belongs to the retroviral Pol polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,148
- Mass (Da)129,871
- Last updated2001-03-01 v1
- Checksum2FA21E439A390D17
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Compositional bias | 26-48 | Polar residues | ||||
Sequence: ETNFPDTTEESAQQICCTRDSSD | ||||||
Compositional bias | 62-79 | Polar residues | ||||
Sequence: IQCQGEGSSRSRGSQPGQ |