Q9DTD8 · Q9DTD8_9HEPC

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell lipid droplet
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell nucleus
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componenthost cell plasma membrane
Cellular Componentlipid droplet
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Cellular Componentviral envelope
Cellular Componentviral nucleocapsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionchannel activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Molecular Functionzinc ion binding
Biological Processapoptotic process
Biological Processfusion of virus membrane with host endosome membrane
Biological Processinduction by virus of host autophagy
Biological Processmonoatomic ion transmembrane transport
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
Biological Processsymbiont-mediated suppression of host TRAF-mediated signal transduction
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processtransformation of host cell by virus
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HCVT212
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus

Accessions

  • Primary accession
    Q9DTD8

Proteomes

Subcellular Location

Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host cell membrane
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host lipid droplet
Host mitochondrion
Host nucleus
Lipid droplet
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Membrane
; Single-pass type I membrane protein
Mitochondrion
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane719-741Helical
Transmembrane753-779Helical
Transmembrane785-804Helical
Transmembrane816-836Helical
Transmembrane892-914Helical
Transmembrane1661-1689Helical
Transmembrane1852-1871Helical
Transmembrane1883-1903Helical
Transmembrane2991-3008Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-75Disordered
Compositional bias47-69Basic and acidic residues
Domain904-1027Peptidase C18
Domain1028-1209Peptidase S29
Domain1218-1370Helicase ATP-binding
Domain1362-1539Helicase C-terminal
Region2188-2221Disordered
Compositional bias2196-2218Polar residues
Compositional bias2352-2370Polar residues
Region2352-2408Disordered
Domain2634-2752RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,011
  • Mass (Da)
    326,853
  • Last updated
    2001-03-01 v1
  • Checksum
    068D3BDF753F184D
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRAWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTIPASAYEVRNVSGGYHVTNDCSNSSIVYETADMIMHTPGCVPCVRESNYSRCWVALTPTLAARNNSVPTMTIRRHIDLLVGTAAFCSAMYVGDLCGSVFLVSQLFTFSPRRHETVQDCNCSIYPGHLTGHRMAWDMMMNWSPTAALVVSQLLRIPQAVVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGRIGLIGGTTSLNTFRVASIFSPGPSQKIQLVNTNGSWHINRTALDCKASLQTGFLAGLLYAKKFNTSGCLERMASCRPIDTFAQGWGPITYTERVNSDQKPYCWHYAPRRCGIIPASQVCGPVYCFTPSPVVVGTTDHLGAPTSVRGENGTDVLLLNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGGGGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTFNFTIFKVRMYVGGVEHRLSVACNWTRGERCNLEDRDRSELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHQGIVDVQYLYGIGSAFVSFAIKWEYVLLLFLLLADARVCACLWMMLLIAQAEAALENLVVLNAASVAGAHGILSFLVFFCAAWYIKGRLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFIGLAFLTLSPYYKVFLARLIWWLQYFITRAEAHLLVWVPPLNVRGGRDAIILLTCAIHPELIFDITKLLLAILGPLMVLQAGITAVPYFVRAQGLIRACMLVRKVAGGHYVQMALVKLAALTGTYVYDHLTPLQDWAHVALRDLAVAVEPVVFSDMETKIITWGADTAACGDIILGLPVSARRGKEILLGPADSLEGQGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCINGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWLAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLSFGAYMSKAHGTDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSNTGEVPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLSALGLNAVAYYRGLDVSVIPTNGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSIRLRAYLNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEIILTHPITKFIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVVPDREVLYREFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTATKQAEAAVPVVESKWQALETFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSPLTTQSTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGRVLVDILAGYGAGVAGALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVHWMNRLIAFASRGNHVSPTHYVPESDAAARVTQILSNLTITQLLKRLHQWINEDCSTPCSGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGEGIMQTTCPCGAQIAGHVKNGSMRIVGPKTCSNVWHGTFPINAYTTGPCTPSPAPNYSKALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLRDEVSFQVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETARRRLARGSPPSLASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRGFPPAIPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPTRAPPIPPPRRKRTIVLTESTVSSALAELATKTFSSSGSSAVDSGTATAPPDQASDDGDKESDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSYTWTGALITPCAAEESKLPINALSNSLLRNHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIRSVWKDLLEDTVTPIDTTVMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLSPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICDSAGVQEDEACLRAFTEAMTRYSAPPGDPPQPAYDLELITSCSSNVSVAHDASGRRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWVRMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRIWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHSLSRARPRWFMLCLLLLSVGVGVYLLPNR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias47-69Basic and acidic residues
Compositional bias2196-2218Polar residues
Compositional bias2352-2370Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB049099
EMBL· GenBank· DDBJ
BAB18812.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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