Q9DE66 · KERA_COTJA
- ProteinKeratocan
- GeneKERA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids353 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Plays an important role in generating and maintaining a transparent matrix within the corneal stroma.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | cornea development in camera-type eye |
Names & Taxonomy
Protein names
- Recommended nameKeratocan
- Short namesKTN
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Perdicinae > Coturnix
Accessions
- Primary accessionQ9DE66
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MMTLKVCPSLLLLFLVHSVWT | ||||||
Chain | PRO_0000032751 | 22-353 | Keratocan | |||
Sequence: RTVRQVYNELDPEHWSHYTFECPQECFCPPSFPNALYCDNKGLKEIPAIPARIWYLYLQNNLIETISEKPFVNATHLRWINLNKNKITNNGIESGVLSKLKRLLYLFLEDNELEEVPAPLPVGLEQLRLARNKISRIPEGVFSNLENLTMLDLHQNNLLDSALQSDTFQGLNSLMQLNIAKNSLKKMPLSIPANTLQLFLDNNSIEVIPENYFSAIPKVTFLRLNYNKLSDEGIPPNGFNVSSILDLQLSHNQLTKIPPINAHLEHLHLDHNRIKSVNGTQICPVSIAVAEDYGLYGNIPRLRYLRLDGNEIQPPIPLDIMICFQLLQAVVI | ||||||
Disulfide bond | 43↔49 | |||||
Sequence: CPQECFC | ||||||
Disulfide bond | 47↔59 | |||||
Sequence: CFCPPSFPNALYC | ||||||
Glycosylation | 94 | N-linked (GlcNAc...) (keratan sulfate) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 168 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 223 | N-linked (GlcNAc...) (keratan sulfate) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 261 | N-linked (GlcNAc...) (keratan sulfate) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 299 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 304↔344 | |||||
Sequence: CPVSIAVAEDYGLYGNIPRLRYLRLDGNEIQPPIPLDIMIC |
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Cornea.
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-72 | LRRNT | ||||
Sequence: EHWSHYTFECPQECFCPPSFPNALYCDNKGLKEIPAIPA | ||||||
Repeat | 73-94 | LRR 1 | ||||
Sequence: RIWYLYLQNNLIETISEKPFVN | ||||||
Repeat | 97-118 | LRR 2 | ||||
Sequence: HLRWINLNKNKITNNGIESGVL | ||||||
Repeat | 123-143 | LRR 3 | ||||
Sequence: RLLYLFLEDNELEEVPAPLPV | ||||||
Repeat | 144-165 | LRR 4 | ||||
Sequence: GLEQLRLARNKISRIPEGVFSN | ||||||
Repeat | 168-188 | LRR 5 | ||||
Sequence: NLTMLDLHQNNLLDSALQSDT | ||||||
Repeat | 194-214 | LRR 6 | ||||
Sequence: SLMQLNIAKNSLKKMPLSIPA | ||||||
Repeat | 215-236 | LRR 7 | ||||
Sequence: NTLQLFLDNNSIEVIPENYFSA | ||||||
Repeat | 239-259 | LRR 8 | ||||
Sequence: KVTFLRLNYNKLSDEGIPPNG | ||||||
Repeat | 264-283 | LRR 9 | ||||
Sequence: SILDLQLSHNQLTKIPPINA | ||||||
Repeat | 284-305 | LRR 10 | ||||
Sequence: HLEHLHLDHNRIKSVNGTQICP |
Sequence similarities
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length353
- Mass (Da)40,280
- Last updated2001-03-01 v1
- ChecksumDEE07614FC598F7D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF128223 EMBL· GenBank· DDBJ | AAG48156.1 EMBL· GenBank· DDBJ | mRNA |