Q9DD05 · Q9DD05_MOUSE
- ProteinDelta-aminolevulinic acid dehydratase
- GeneAlad
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids330 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 122 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 124 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 131 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 132 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Active site | 199 | Schiff-base intermediate with substrate | |||
Binding site | 209 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 221 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 223 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Active site | 252 | Schiff-base intermediate with substrate | |||
Binding site | 279 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
Binding site | 318 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | porphobilinogen synthase activity | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9DD05
Organism-specific databases
Interaction
Subunit
Homooctamer; active form. Homohexamer; low activity form.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length330
- Mass (Da)36,040
- Last updated2001-06-01 v1
- MD5 Checksum11754E2B9F4DA2141D950B93DB1FB0B6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK002300 EMBL· GenBank· DDBJ | BAB21998.1 EMBL· GenBank· DDBJ | mRNA |