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Q9DD05 · Q9DD05_MOUSE

  • Protein
    Delta-aminolevulinic acid dehydratase
  • Gene
    Alad
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

133050100150200250300
Type
IDPosition(s)Description
Binding site122Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site124Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site131Zn2+ 2 (UniProtKB | ChEBI)
Binding site132Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site199Schiff-base intermediate with substrate
Binding site2095-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2215-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site223Zn2+ 2 (UniProtKB | ChEBI)
Active site252Schiff-base intermediate with substrate
Binding site2795-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3185-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionporphobilinogen synthase activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • Name
      Alad

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9DD05

Organism-specific databases

Interaction

Subunit

Homooctamer; active form. Homohexamer; low activity form.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    330
  • Mass (Da)
    36,040
  • Last updated
    2001-06-01 v1
  • MD5 Checksum
    11754E2B9F4DA2141D950B93DB1FB0B6
MHHQSVLHSGYFHPLLRSWQTAASTVSASNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGAFLSEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADMLMVKPGLPYLDMVREVKDKHPELPLAVYQVSGEFAMLWHGAQAGAFDLRTAVLETMTAFRRAGADIIITYFAPQLLKWLKEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK002300
EMBL· GenBank· DDBJ
BAB21998.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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