Q9DCU9 · HOGA1_MOUSE
- Protein4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- GeneHoga1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids321 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the final step in the metabolic pathway of hydroxyproline.
Catalytic activity
- (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Activity regulation
Inhibited by divalent cations.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 71-72 | substrate | ||||
Sequence: ST | ||||||
Site | 162 | Involved in proton transfer during cleavage | ||||
Sequence: Y | ||||||
Active site | 190 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 192 | substrate | ||||
Sequence: S | ||||||
Binding site | 216 | substrate | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity | |
Molecular Function | 4-hydroxy-2-oxoglutarate aldolase activity | |
Molecular Function | N-acetylneuraminate lyase activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | 4-hydroxyproline catabolic process | |
Biological Process | glyoxylate catabolic process | |
Biological Process | N-acetylneuraminate catabolic process | |
Biological Process | oxalate metabolic process | |
Biological Process | pyruvate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9DCU9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-23 | Mitochondrion | ||||
Sequence: MLGPQIWASMRQGLSRGLSRNVK | ||||||
Chain | PRO_0000273347 | 24-321 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial | |||
Sequence: GKKVDIAGIYPPVTTPFTATAEVDYGKLEENLNRLATFPFRGFVVQGSTGEFPFLTSLERLEVVSRVRQAIPKDKFLIAGSGCESTQATVEMTVSMAQVGADVAMVVTPCYYRGRMSSAALIHHYTKVADVSPIPVVLYSVPANTGLELPVDAVVTLSQHPNIIGLKDSGGDVTRIGLIVHKTSKQDFQVLAGSAGFLLASYAVGAVGGICGLANVLGAQVCQLERLCLTGQWEAAQELQHRLIEPNTAVTRRFGIPGLKKTMDWFGYYGGPCRAPLQELSPTEEEALRLDFSNNGWL |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length321
- Mass (Da)34,644
- Last updated2001-06-01 v1
- Checksum75B3DC959756D5A7
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9Q1R2 | E9Q1R2_MOUSE | Hoga1 | 158 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 25 | in Ref. 1; BAB27226 | ||||
Sequence: K → M |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK002457 EMBL· GenBank· DDBJ | BAB22114.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010857 EMBL· GenBank· DDBJ | BAB27226.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BC016430 EMBL· GenBank· DDBJ | AAH16430.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |