Q9DCJ5 · NDUA8_MOUSE

  • Protein
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
  • Gene
    Ndufa8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial intermembrane space
Cellular Componentmitochondrion
Cellular Componentrespiratory chain complex I
Molecular Functionprotein-containing complex binding
Biological Processaerobic respiration
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processmitochondrial respiratory chain complex I assembly
Biological Processproton motive force-driven mitochondrial ATP synthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
  • Alternative names
    • Complex I-19kD (CI-19kD)
    • Complex I-PGIV (CI-PGIV)
    • NADH-ubiquinone oxidoreductase 19 kDa subunit

Gene names

    • Name
      Ndufa8

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9DCJ5
  • Secondary accessions
    • A2AL45

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for initiator methionine, chain, disulfide bond.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001187352-172NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Disulfide bond36↔66
Disulfide bond46↔56
Disulfide bond78↔110
Disulfide bond88↔100

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Complex I is composed of 45 different subunits.
View interactors in UniProtKB
View CPX-266 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain33-74CHCH 1
Motif36-46Cx9C motif 1
Motif56-66Cx9C motif 2
Domain75-118CHCH 2
Motif78-88Cx9C motif 3
Motif100-110Cx9C motif 4

Domain

Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.

Sequence similarities

Belongs to the complex I NDUFA8 subunit family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    172
  • Mass (Da)
    19,992
  • Last updated
    2007-01-23 v3
  • Checksum
    7DF62AB86B5BF684
MPGIVELPTLEELKVEEVKVSSAVLKAAAHHYGAQCDKTNKEFMLCRWEEKDPRRCLKEGKLVNGCALNFFRQIKSHCAEPFTEYWTCLDYSNMQLFRHCRQQQAKFDQCVLDKLGWVRPDLGQLSKVTKVKTDRPLPENPYHSRARPEPNPVIEGDLKPAKHGTRFFFWTV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK002744
EMBL· GenBank· DDBJ
BAB22322.1
EMBL· GenBank· DDBJ
mRNA
AL773525
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC012416
EMBL· GenBank· DDBJ
AAH12416.1
EMBL· GenBank· DDBJ
mRNA
BC024673
EMBL· GenBank· DDBJ
AAH24673.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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