Q9DB15 · RM12_MOUSE

  • Protein
    Large ribosomal subunit protein bL12m
  • Gene
    Mrpl12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial large ribosomal subunit
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrial ribosome
Cellular Componentmitochondrion
Molecular FunctionmRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processmitochondrial transcription
Biological Processmitochondrial translation
Biological Processpositive regulation of DNA-templated transcription
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein bL12m
  • Alternative names
    • 39S ribosomal protein L12, mitochondrial (L12mt; MRP-L12)

Gene names

    • Name
      Mrpl12
    • Synonyms
      Rpml12

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9DB15
  • Secondary accessions
    • B1ATZ3
    • Q3TKJ3
    • Q99JS8

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-46Mitochondrion
ChainPRO_000003045947-201Large ribosomal subunit protein bL12m
Modified residue141N6-acetyllysine
Modified residue153N6-succinyllysine
Modified residue165N6-succinyllysine
Modified residue181N6-succinyllysine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
Interacts with NOA1
View interactors in UniProtKB
View CPX-5302 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region37-60Disordered
Region109-130Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    201
  • Mass (Da)
    21,708
  • Last updated
    2001-12-13 v2
  • Checksum
    893BEFB4F154076D
MLPVAASRCLWGPRLGLRGAALRLARQQMPSVCAARQLRSSSHRRSEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLMPMGGMVPGPVSAAAPASEAAEEEDVPKQKERTHFTVRLTEAKPVDKVKLIKEIKNYVQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict8-18in Ref. 1; BAB23955

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK005328
EMBL· GenBank· DDBJ
BAB23955.1
EMBL· GenBank· DDBJ
mRNA
AK028168
EMBL· GenBank· DDBJ
BAC25787.1
EMBL· GenBank· DDBJ
mRNA
AK134816
EMBL· GenBank· DDBJ
BAE22297.1
EMBL· GenBank· DDBJ
mRNA
AK166969
EMBL· GenBank· DDBJ
BAE39152.1
EMBL· GenBank· DDBJ
mRNA
AK168337
EMBL· GenBank· DDBJ
BAE40275.1
EMBL· GenBank· DDBJ
mRNA
AL669855
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC005712
EMBL· GenBank· DDBJ
AAH05712.1
EMBL· GenBank· DDBJ
mRNA
BC019565
EMBL· GenBank· DDBJ
AAH19565.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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