Q9DB00 · GON4L_MOUSE
- ProteinGON-4-like protein
- GeneGon4l
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2260 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1 (PubMed:21454521).
Required for B cell lymphopoiesis (PubMed:20530203).
Required for B cell lymphopoiesis (PubMed:20530203).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | transcription coregulator activity | |
Molecular Function | transcription corepressor activity | |
Biological Process | B cell differentiation | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameGON-4-like protein
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9DB00
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197110 | 1-2260 | GON-4-like protein | |||
Sequence: MLPCKKRRLSVTESSQQQDDQEGDDLDLEAAVKPDTDQLPDSASESLSWGQSQDSAVCPEGLSMQDGDDQLRAEGLSLNSKMLAQHVNLAVLEAVDVAVSQEIPLPSLESSHSLPVHVDKGRLQVSASKKGKRVVFTPGQVTREDRGDHPVPEEPPSGEPAEEAKTEGGELELRSDGEVPLLSSSSQSAKPGAQPRKSVQPDGSAFPQDKPLGPLVRQAEEEMEDGGLFIPTEEQDSEESDKKKKTKKGTKRKRDGKGPEQGTMVYDPKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFEPKMTRSKLKEVVEKGVVIPTWNISPIKKASEIKQPPQFVDIHLEEDDSSDEEYSPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRLSSEVAETDEESGMLSEVEKAATPALRHISAEVVPMGPPPPPKPKQSRDSVFMEKLDAVDEELASSPVCMDSFQPMEDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKQWLGGLINDDVENEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNGLMEELFETVQSVVPSKFQDEMGFSNMEDDGPEEEERATESRPSFNTPQALRFEEPLANLLNERHRTVKELLEQLKMKKPSVRQQPEVEKLKPQEEAAHQTLVLDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGTFAENSIALHQQFNPRFQTLFQPCNWMGAMRLIEDFTQVSIDCSPHKTAKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPRDKTIFTKAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQLTVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRLPFWLKASLQSIQDELRNISEGATEGGSVTTATESSTDQHLQKASPALGDEPQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVRGEDGFESPTALPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYVRRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTTVFSKEEPKSWHSSADTGSQEAFSESSACSWAVVKTESQEGSSEKSACGWTVVKTEDGGHAVEPLPQNLQDSLSSSSKDLLNMVKMEAQDCMVEISSNFPKQDIGEEVKEECSMELDSESPQEKPSSASEMSKQTVLQREDMQAAKSPSVPQDAAAEGRTSSHASRGLPKSTLSSMGQGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEEDELSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMETLQKEDEVNDEAVGDAAKKPPSTLASPQTAPEIETSIAPAGESIKAAGKGRSSHRARNKRGSRARASKDTSKLLLLYDEDILDRDPLREQKDLAFAQAYLTRVREALQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVILPDVEEDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEAAKDCSCSCHEGGPESKLKKSKRRNCHCSSKVCDSKPYKSKEPPELVGSGPLHEASTVPGSKEAGQGKDMLEEEILEEQENMEVTQSKTARTTRKGEAPAPGSTIGSTLLCPAEVTPMELLLEGPALCSAETPRLPPQTGAVVCSVRRNQAGPEVVSCLSTSSLPPEEGEDQRAAANSETIAPHREASETERLPETVEHSAPLPSPVSTRTRDTGRRHICGKAGSQSWLIESRAEAEAAHVAAPICEKSSGARASEAAPKTAREVLAEDSGTQGMGPEGALPKASEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE | ||||||
Modified residue | 347 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 784 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1925 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1998 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in thymus. Specifically expressed in B cells and their precursors (at protein level). Also detected in brain, heart, spleen and bone marrow.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-67 | Disordered | ||||
Sequence: MLPCKKRRLSVTESSQQQDDQEGDDLDLEAAVKPDTDQLPDSASESLSWGQSQDSAVCPEGLSMQDG | ||||||
Compositional bias | 39-59 | Polar residues | ||||
Sequence: LPDSASESLSWGQSQDSAVCP | ||||||
Region | 137-212 | Disordered | ||||
Sequence: TPGQVTREDRGDHPVPEEPPSGEPAEEAKTEGGELELRSDGEVPLLSSSSQSAKPGAQPRKSVQPDGSAFPQDKPL | ||||||
Compositional bias | 142-174 | Basic and acidic residues | ||||
Sequence: TREDRGDHPVPEEPPSGEPAEEAKTEGGELELR | ||||||
Compositional bias | 179-194 | Polar residues | ||||
Sequence: VPLLSSSSQSAKPGAQ | ||||||
Region | 228-264 | Disordered | ||||
Sequence: LFIPTEEQDSEESDKKKKTKKGTKRKRDGKGPEQGTM | ||||||
Compositional bias | 367-392 | Acidic residues | ||||
Sequence: EEDDSSDEEYSPDEEEEDETAEESLL | ||||||
Region | 367-434 | Disordered | ||||
Sequence: EEDDSSDEEYSPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRLSSEVAETDEESGMLSEVEKAA | ||||||
Compositional bias | 546-572 | Acidic residues | ||||
Sequence: DVENEDEADDDDDPEYNFLEDLDEPDT | ||||||
Region | 546-576 | Disordered | ||||
Sequence: DVENEDEADDDDDPEYNFLEDLDEPDTEDFR | ||||||
Region | 610-1364 | Required for interaction with YY1, SIN3A and HDAC1, and transcriptional repression activity | ||||
Sequence: EMGFSNMEDDGPEEEERATESRPSFNTPQALRFEEPLANLLNERHRTVKELLEQLKMKKPSVRQQPEVEKLKPQEEAAHQTLVLDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGTFAENSIALHQQFNPRFQTLFQPCNWMGAMRLIEDFTQVSIDCSPHKTAKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPRDKTIFTKAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQLTVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRLPFWLKASLQSIQDELRNISEGATEGGSVTTATESSTDQHLQKASPALGDEPQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVRGEDGFESPTALPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYVRRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTTVFSKEEPKSWHSSADTGSQEAFSESSACSWAVVKTESQEGSSEKSACGWTVVKTEDGGHAVEPLPQNLQDSLSSSSKDLLNMVKMEAQDCMVEISSNF | ||||||
Region | 613-634 | Disordered | ||||
Sequence: FSNMEDDGPEEEERATESRPSF | ||||||
Compositional bias | 946-967 | Polar residues | ||||
Sequence: GATEGGSVTTATESSTDQHLQK | ||||||
Region | 946-976 | Disordered | ||||
Sequence: GATEGGSVTTATESSTDQHLQKASPALGDEP | ||||||
Region | 1367-1625 | Disordered | ||||
Sequence: QDIGEEVKEECSMELDSESPQEKPSSASEMSKQTVLQREDMQAAKSPSVPQDAAAEGRTSSHASRGLPKSTLSSMGQGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEEDELSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMETLQKEDEVNDEAVGDAAKKPPSTLASPQTAPEIETSIAPAGESIKAAGKGRSSHRARNKRGSRARA | ||||||
Compositional bias | 1368-1383 | Basic and acidic residues | ||||
Sequence: DIGEEVKEECSMELDS | ||||||
Compositional bias | 1384-1407 | Polar residues | ||||
Sequence: ESPQEKPSSASEMSKQTVLQREDM | ||||||
Compositional bias | 1419-1444 | Polar residues | ||||
Sequence: AAAEGRTSSHASRGLPKSTLSSMGQG | ||||||
Compositional bias | 1477-1502 | Acidic residues | ||||
Sequence: KDGPEEEEEEDFDDLTQDEEDELSSA | ||||||
Compositional bias | 1536-1560 | Acidic residues | ||||
Sequence: EEENSQEENSEPEEEEEEEAEGMET | ||||||
Domain | 1648-1720 | PAH 1 | ||||
Sequence: EQKDLAFAQAYLTRVREALQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFLLPE | ||||||
Domain | 1730-1801 | PAH 2 | ||||
Sequence: EQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHL | ||||||
Region | 1835-1935 | Disordered | ||||
Sequence: VEEDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEAAKDCSCSCHEGGPESKLKKSKRRNCHCSSKVCDSKPYKSKEPPELVGSGPLHEASTVPGSKEAGQ | ||||||
Compositional bias | 1837-1870 | Basic and acidic residues | ||||
Sequence: EDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEA | ||||||
Compositional bias | 1896-1910 | Basic and acidic residues | ||||
Sequence: HCSSKVCDSKPYKSK | ||||||
Region | 1949-1974 | Disordered | ||||
Sequence: ENMEVTQSKTARTTRKGEAPAPGSTI | ||||||
Region | 2026-2088 | Disordered | ||||
Sequence: SCLSTSSLPPEEGEDQRAAANSETIAPHREASETERLPETVEHSAPLPSPVSTRTRDTGRRHI | ||||||
Region | 2134-2162 | Disordered | ||||
Sequence: VLAEDSGTQGMGPEGALPKASEATVCANN | ||||||
Domain | 2167-2220 | Myb-like | ||||
Sequence: STGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELM | ||||||
Region | 2227-2260 | Disordered | ||||
Sequence: CEASSEDEDDATSTSNADQLSDHGDLLSEEELDE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,260
- Mass (Da)248,742
- Last updated2011-07-27 v3
- ChecksumBB0F605666D642C6
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I4T097 | A0A8I4T097_MOUSE | Gon4l | 75 | ||
A0A8I4SX99 | A0A8I4SX99_MOUSE | Gon4l | 177 | ||
A0A8I4SX68 | A0A8I4SX68_MOUSE | Gon4l | 64 | ||
E9Q507 | E9Q507_MOUSE | Gon4l | 2242 | ||
A0A8I4SYD0 | A0A8I4SYD0_MOUSE | Gon4l | 138 | ||
A0A1D5RM47 | A0A1D5RM47_MOUSE | Gon4l | 141 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 39-59 | Polar residues | ||||
Sequence: LPDSASESLSWGQSQDSAVCP | ||||||
Compositional bias | 142-174 | Basic and acidic residues | ||||
Sequence: TREDRGDHPVPEEPPSGEPAEEAKTEGGELELR | ||||||
Compositional bias | 179-194 | Polar residues | ||||
Sequence: VPLLSSSSQSAKPGAQ | ||||||
Sequence conflict | 259 | in Ref. 3; BAC65813 | ||||
Sequence: P → L | ||||||
Compositional bias | 367-392 | Acidic residues | ||||
Sequence: EEDDSSDEEYSPDEEEEDETAEESLL | ||||||
Compositional bias | 546-572 | Acidic residues | ||||
Sequence: DVENEDEADDDDDPEYNFLEDLDEPDT | ||||||
Sequence conflict | 734 | in Ref. 3; BAC65813 | ||||
Sequence: I → V | ||||||
Compositional bias | 946-967 | Polar residues | ||||
Sequence: GATEGGSVTTATESSTDQHLQK | ||||||
Sequence conflict | 1080 | in Ref. 3; BAC65813 | ||||
Sequence: A → S | ||||||
Sequence conflict | 1341 | in Ref. 3; BAC65813 | ||||
Sequence: S → P | ||||||
Sequence conflict | 1354 | in Ref. 3; BAC65813 | ||||
Sequence: Q → E | ||||||
Sequence conflict | 1364 | in Ref. 3; BAC65813 | ||||
Sequence: F → L | ||||||
Compositional bias | 1368-1383 | Basic and acidic residues | ||||
Sequence: DIGEEVKEECSMELDS | ||||||
Compositional bias | 1384-1407 | Polar residues | ||||
Sequence: ESPQEKPSSASEMSKQTVLQREDM | ||||||
Sequence conflict | 1392 | in Ref. 3; BAC65813 | ||||
Sequence: S → R | ||||||
Sequence conflict | 1407 | in Ref. 3; BAC65813 | ||||
Sequence: M → T | ||||||
Compositional bias | 1419-1444 | Polar residues | ||||
Sequence: AAAEGRTSSHASRGLPKSTLSSMGQG | ||||||
Sequence conflict | 1438 | in Ref. 3; BAC65813 | ||||
Sequence: L → P | ||||||
Sequence conflict | 1458 | in Ref. 3; BAC65813 | ||||
Sequence: A → V | ||||||
Compositional bias | 1477-1502 | Acidic residues | ||||
Sequence: KDGPEEEEEEDFDDLTQDEEDELSSA | ||||||
Compositional bias | 1536-1560 | Acidic residues | ||||
Sequence: EEENSQEENSEPEEEEEEEAEGMET | ||||||
Compositional bias | 1837-1870 | Basic and acidic residues | ||||
Sequence: EDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEA | ||||||
Compositional bias | 1896-1910 | Basic and acidic residues | ||||
Sequence: HCSSKVCDSKPYKSK | ||||||
Sequence conflict | 2069 | in Ref. 3; BAC65813 and 4; AAH16616 | ||||
Sequence: S → P |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC127377 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK005385 EMBL· GenBank· DDBJ | BAB23992.1 EMBL· GenBank· DDBJ | mRNA | Different termination. | |
AK122531 EMBL· GenBank· DDBJ | BAC65813.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC016616 EMBL· GenBank· DDBJ | AAH16616.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |