Q9DAN6 · GTSF1_MOUSE

  • Protein
    Gametocyte-specific factor 1
  • Gene
    Gtsf1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.

Features

Showing features for binding site.

116720406080100120140160
TypeIDPosition(s)Description
Binding site17Zn2+ 1 (UniProtKB | ChEBI)
Binding site23Zn2+ 1 (UniProtKB | ChEBI)
Binding site33Zn2+ 1 (UniProtKB | ChEBI)
Binding site37Zn2+ 1 (UniProtKB | ChEBI)
Binding site51Zn2+ 2 (UniProtKB | ChEBI)
Binding site57Zn2+ 2 (UniProtKB | ChEBI)
Binding site67Zn2+ 2 (UniProtKB | ChEBI)
Binding site71Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentpiP-body
Molecular Functionmetal ion binding
Biological Processcell differentiation
Biological ProcesspiRNA-mediated gene silencing by mRNA destabilization
Biological Processsecondary piRNA processing
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Gametocyte-specific factor 1
  • Alternative names
    • Protein FAM112B

Gene names

    • Name
      Gtsf1
    • Synonyms
      Cue110
      , Fam112b

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9DAN6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Mutant mice grow normally and appear healthy but males are sterile due to massive germ cell apoptotic death after postnatal day 14 with meiocytes ceasing meiotic progression before the early meitoic phase. There is also increased transcription of LINE-1 and IAP retrotransposons accompanied by demethylation of their promoter regions.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002216221-167Gametocyte-specific factor 1
Modified residue8Phosphoserine

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Tissue specificity

Expressed abundantly in adult testis, at moderate levels in unfertilized eggs and ovaries and weakly in embryonic stem cells.

Developmental stage

In the male gonad, barely detected at 13.5 dpc or at birth, detected weakly on postnatal day 14 and maximally expressed in the 4- or 7-week-old mouse testis but not detected in the epididymis of the 7-week-old mouse (at protein level). In the female gonad, low levels detected at birth (at protein level). In the adult testis, present predominantly in pachytene spermatocytes and round spermatids but not in spermatogonia, preleptotene spermatocytes or elongating spermatids (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger.

TypeIDPosition(s)Description
Zinc finger14-41CHHC U11-48K-type 1
Zinc finger48-75CHHC U11-48K-type 2

Sequence similarities

Belongs to the UPF0224 (FAM112) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    19,083
  • Last updated
    2001-06-01 v1
  • Checksum
    CF370101EAAF7314
MEDTYIDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTASFCGNNSPANNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6SXE5F6SXE5_MOUSEGtsf1194
D3YV29D3YV29_MOUSEGtsf1186
D3YUE6D3YUE6_MOUSEGtsf1161
D3YWV9D3YWV9_MOUSEGtsf1127

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK005675
EMBL· GenBank· DDBJ
BAB24181.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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