Q9D9T0 · DYDC1_MOUSE

  • Protein
    DPY30 domain-containing protein 1
  • Gene
    Dydc1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:36417862).
Plays a crucial role during acrosome biogenesis (PubMed:19545932).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Component9+2 motile cilium
Cellular Componentextracellular region
Cellular Componentradial spoke
Cellular ComponentSet1C/COMPASS complex
Cellular Componentsperm flagellum
Biological Processepithelial cilium movement involved in extracellular fluid movement
Biological Processflagellated sperm motility
Biological Processmating

Names & Taxonomy

Protein names

  • Recommended name
    DPY30 domain-containing protein 1

Gene names

    • Name
      Dydc1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D9T0
  • Secondary accessions
    • G3X8U6
    • Q810Q6

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002475571-175DPY30 domain-containing protein 1

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (PubMed:36417862).
Interacts with SH3GL3 (By similarity).
View interactors in UniProtKB
View CPX-8161 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias94-109Basic and acidic residues
Region94-134Disordered
Region152-175Disordered

Sequence similarities

Belongs to the dpy-30 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9D9T0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    175
  • Mass (Da)
    20,494
  • Last updated
    2012-10-03 v2
  • Checksum
    45EAB6A38F877069
MESRYLQKCLGTCLTQGLTEVARVRPLDPIEYLAFWLYKHKENMNMEQMRQREMITLEHERELAMMEQEMLERLKAEELLFQQQLAFQLELEMQQKEKQKSEDFETGQEKSFKSMMSMESTARGEEQEPMQAEELVMDSGKTLAEISDRYGAPNLSRVEELDEPMLSDNGVSAPP

Q9D9T0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E0CXB0E0CXB0_MOUSEDydc1177

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_02001269-84in isoform 2
Compositional bias94-109Basic and acidic residues
Sequence conflict152in Ref. 1; BAB24626

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK006511
EMBL· GenBank· DDBJ
BAB24626.1
EMBL· GenBank· DDBJ
mRNA
AC154597
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466573
EMBL· GenBank· DDBJ
EDL24916.1
EMBL· GenBank· DDBJ
Genomic DNA
BC049632
EMBL· GenBank· DDBJ
AAH49632.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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