Q9D8W6 · Q9D8W6_MOUSE

  • Protein
    GTP:AMP phosphotransferase AK3, mitochondrial
  • Gene
    Ak3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

118920406080100120140160180
TypeIDPosition(s)Description
Binding site17-22GTP (UniProtKB | ChEBI)
Binding site38AMP (UniProtKB | ChEBI)
Binding site43AMP (UniProtKB | ChEBI)
Binding site64-66AMP (UniProtKB | ChEBI)
Binding site91-94AMP (UniProtKB | ChEBI)
Binding site98AMP (UniProtKB | ChEBI)
Binding site128GTP (UniProtKB | ChEBI)
Binding site137-138GTP (UniProtKB | ChEBI)
Binding site161AMP (UniProtKB | ChEBI)
Binding site172AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular Functionnucleoside diphosphate kinase activity
Molecular Functionnucleoside triphosphate adenylate kinase activity
Biological ProcessADP biosynthetic process
Biological ProcessAMP metabolic process
Biological ProcessGTP metabolic process
Biological ProcessITP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP:AMP phosphotransferase AK3, mitochondrial
  • EC number
  • Alternative names
    • Adenylate kinase 3
      (AK 3
      )
    • Adenylate kinase 3 alpha-like 1

Gene names

    • Name
      Ak3
    • Synonyms
      AK3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D8W6

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region37-66NMPbind
Region127-164LID
Domain128-163Adenylate kinase active site lid

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. AK3 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    21,194
  • Last updated
    2001-06-01 v1
  • Checksum
    822ADB21804F5336
MGASGRLLRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCSWLLDGFPRTLPQAEALDKVYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK007618
EMBL· GenBank· DDBJ
BAB25139.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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