Q9D5U8 · CNBD2_MOUSE
- ProteinCyclic nucleotide-binding domain-containing protein 2
- GeneCnbd2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids673 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm (PubMed:24339785).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | cAMP binding | |
Biological Process | spermatogenesis |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCyclic nucleotide-binding domain-containing protein 2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9D5U8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Males are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca2+ regulation of the flagellar beat of sperm.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000079473 | 1-673 | Cyclic nucleotide-binding domain-containing protein 2 | |||
Sequence: MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWTAKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRISFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITEDEDGSSAFLDPHPTLLHRGGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAYYKWVWQQLELLDHKPLRIHDNEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQGIDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTEEGEIVGLHQAFVPEIQRDCRPFILLSLGSELIQVRKEKFYDMVDEETRAKIIKMDVDYPSDEDLCQSFLKENDYIVFRKDLLRLLVEPLNKSPFIPVQTKKKEIYNHKSLFLDLCSLEKKVKQHYPIFLAPQKYLPPLRVVQAISAPRHKIQELLPQYKNAGVLI |
Proteomic databases
PTM databases
Expression
Tissue specificity
Testis-specific. Exclusively expressed in testicular germ cells while it is not present in mature sperm (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGG | ||||||
Region | 1-89 | Disordered | ||||
Sequence: MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQ | ||||||
Compositional bias | 44-81 | Basic and acidic residues | ||||
Sequence: ADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQ |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9D5U8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length673
- Mass (Da)77,892
- Last updated2007-07-24 v2
- ChecksumB316EA21E109FE17
Q9D5U8-2
- Name2
- Differences from canonical
- 172-183: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGG | ||||||
Compositional bias | 44-81 | Basic and acidic residues | ||||
Sequence: ADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQ | ||||||
Alternative sequence | VSP_003825 | 172-183 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 476 | in Ref. 3; AAH27204 | ||||
Sequence: F → Y | ||||||
Sequence conflict | 479 | in Ref. 3; AAH27204 | ||||
Sequence: L → P | ||||||
Sequence conflict | 591 | in Ref. 3; AAH27204 | ||||
Sequence: R → Q | ||||||
Sequence conflict | 657 | in Ref. 1; AK014912 | ||||
Sequence: H → Q |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK014912 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AL928935 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL929404 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC027204 EMBL· GenBank· DDBJ | AAH27204.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |