Q9D5U8 · CNBD2_MOUSE

  • Protein
    Cyclic nucleotide-binding domain-containing protein 2
  • Gene
    Cnbd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm (PubMed:24339785).

Features

Showing features for binding site.

167350100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site206-329a nucleoside 3',5'-cyclic phosphate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctioncAMP binding
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic nucleotide-binding domain-containing protein 2
  • Alternative names
    • Cyclic nucleotide receptor involved in sperm function

Gene names

    • Name
      Cnbd2
    • Synonyms
      Cris

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D5U8
  • Secondary accessions
    • A2ATV2
    • Q8R083

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Males are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca2+ regulation of the flagellar beat of sperm.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000794731-673Cyclic nucleotide-binding domain-containing protein 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Testis-specific. Exclusively expressed in testicular germ cells while it is not present in mature sperm (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-35Polar residues
Region1-89Disordered
Compositional bias44-81Basic and acidic residues

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9D5U8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    673
  • Mass (Da)
    77,892
  • Last updated
    2007-07-24 v2
  • Checksum
    B316EA21E109FE17
MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWTAKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRISFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITEDEDGSSAFLDPHPTLLHRGGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAYYKWVWQQLELLDHKPLRIHDNEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQGIDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTEEGEIVGLHQAFVPEIQRDCRPFILLSLGSELIQVRKEKFYDMVDEETRAKIIKMDVDYPSDEDLCQSFLKENDYIVFRKDLLRLLVEPLNKSPFIPVQTKKKEIYNHKSLFLDLCSLEKKVKQHYPIFLAPQKYLPPLRVVQAISAPRHKIQELLPQYKNAGVLI

Q9D5U8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2AV95A2AV95_MOUSECnbd2425
A2AV96A2AV96_MOUSECnbd2544

Sequence caution

The sequence AAH27204.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-35Polar residues
Compositional bias44-81Basic and acidic residues
Alternative sequenceVSP_003825172-183in isoform 2
Sequence conflict476in Ref. 3; AAH27204
Sequence conflict479in Ref. 3; AAH27204
Sequence conflict591in Ref. 3; AAH27204
Sequence conflict657in Ref. 1; AK014912

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK014912
EMBL· GenBank· DDBJ
-mRNA No translation available.
AL928935
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL929404
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC027204
EMBL· GenBank· DDBJ
AAH27204.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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