Q9D3P9 · NEUT_MOUSE
- ProteinNeurotensin/neuromedin N
- GeneNts
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids169 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 159-160 | Cleavage; by MME | ||||
Sequence: PY | ||||||
Site | 160-161 | Cleavage; by ACE and MME | ||||
Sequence: YI |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon terminus | |
Cellular Component | extracellular region | |
Cellular Component | neuronal cell body | |
Cellular Component | transport vesicle | |
Molecular Function | neuropeptide hormone activity | |
Molecular Function | neuropeptide receptor binding | |
Biological Process | blood vessel diameter maintenance | |
Biological Process | negative regulation of gene expression | |
Biological Process | neuropeptide signaling pathway | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | visual learning |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeurotensin/neuromedin N
- Cleaved into 4 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9D3P9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Packaged within secretory vesicles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MRGMNLQLVCLTLLAFSSWSLC | ||||||
Chain | PRO_0000019526 | 23-147 | Large neuromedin N | |||
Sequence: SDSEEDVRALEADLLTNMHTSKISKASPPSWKMTLLNVCSLINNVNSPAEEAGDMHDDDLVGKRKLPLVLDGFSLEAMLTIFQLQKICRSRAFQHWEIIQEDILDNVNDKNEKEEVIKRKIPYIL | ||||||
Peptide | PRO_0000019527 | 142-147 | Neuromedin N | |||
Sequence: KIPYIL | ||||||
Peptide | PRO_0000019528 | 150-162 | Neurotensin | |||
Sequence: QLYENKPRRPYIL | ||||||
Peptide | PRO_0000019529 | 165-169 | Tail peptide | |||
Sequence: GSYYY |
Post-translational modification
Neurotensin
Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length169
- Mass (Da)19,608
- Last updated2001-06-01 v1
- ChecksumD153319F5F0925DC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF348489 EMBL· GenBank· DDBJ | AAK28626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF304160 EMBL· GenBank· DDBJ | AAK15263.1 EMBL· GenBank· DDBJ | mRNA | ||
AK017212 EMBL· GenBank· DDBJ | BAB30636.1 EMBL· GenBank· DDBJ | mRNA | ||
BC043024 EMBL· GenBank· DDBJ | AAH43024.1 EMBL· GenBank· DDBJ | mRNA |